DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VSR7 and Lrp4

DIOPT Version :9

Sequence 1:	NP_001190777.1	Gene:	VSR7 / 827757	AraportID:	AT4G20110	Length:	628	Species:	Arabidopsis thaliana
Sequence 2:	NP_112612.2	Gene:	Lrp4 / 83469	RGDID:	619731	Length:	1905	Species:	Rattus norvegicus

Alignment Length:	414	Identity:	91/414 - (21%)
Similarity:	134/414 - (32%)	Gaps:	154/414 - (37%)

- Green bases have known domain annotations that are detailed below.

plant   193 LW-TNSNDECGARCDEQMDF----VKNFKGHAQILEKGGYTAFTPHYITWF-------------- 238
            || .:.:::||...|||.|.    .|.|:     ...|  :....|   |:
  Rat   126 LWHCDGDNDCGDNSDEQCDMRKCSDKEFR-----CSDG--SCIAEH---WYCDGDTDCKDGSDEE 180

plant   239 -CPFQFINSPHC---KSQCINHGR------YCAPDPEDNFREGYEGKDVVLENLRQLCVHRVANE 293
             || ..:.||.|   :.||. :||      :|  |.:|:..:
  Rat   181 SCP-SAVPSPPCNLEEFQCA-YGRRILDIYHC--DGDDDCGD----------------------- 218

plant   294 SSRPWVWWDYVTDFHSRCSMKEKKYSIDCAESYESLRLFSDLPIEKIKKCIGDPEADTENQVLRT 358
                   |...:|..|....:..::..|           |.|.:....:|.||.:.|
  Rat   219 -------WSDESDCSSHQPCRSGEFMCD-----------SGLCVNAGWRCDGDADCD-------- 257

plant   359 EQVSQIGRGNRGDVTILPTLVINNAQYRGRLERTAVLKAICAGFN---ETSEPAICLNTGLETNE 420
                     ::.|.....|.:....|:|.|..|...|...|.|.:   :.|:...|.|||  :.:
  Rat   258 ---------DQSDERNCTTSMCTAEQFRCRSGRCVRLSWRCDGEDDCADNSDEENCENTG--SPQ 311

plant   421 CLENNGGCWQDTKANITACQDTFRGR------LCECPVVKGVQYKGDG-----YTSCTP-YGPAR 473
            |..:...||              .||      ||     .||...||.     ..:|.| .|...
  Rat   312 CASDQFLCW--------------NGRCIGQRKLC-----NGVNDCGDNSDESPQQNCRPRTGEEN 357

plant   474 CTMNNGGCWSDTR--NGLTFSACSDSVSTGCKCPEGFQ--GDGLTCEDINECKERSVCQCSGCRC 534
            |.:|||||....:  .|          :..|.|..|::  .||.||:|:|||.|...|...   |
  Rat   358 CNVNNGGCAQKCQMIRG----------AVQCTCHTGYRLTEDGRTCQDVNECAEEGYCSQG---C 409

plant   535 KNSWGGYKCSCSGDRLYINDQDTC 558
            .||.|.::|.|........|:.:|
  Rat   410 TNSEGAFQCWCEAGYELRPDRRSC 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VSR7	NP_001190777.1	PA_VSR	53..176	CDD:239040
		VESA1_N	<494..>564	CDD:289551	21/67 (31%)
		EGF_CA	517..>545	CDD:238011	11/27 (41%)
Lrp4	NP_112612.2	LDLa	27..66	CDD:238060
		Ldl_recept_a	70..105	CDD:278486
		LDLa	110..142	CDD:238060	5/15 (33%)
		LDLa	148..182	CDD:238060	5/43 (12%)
		LDLa	231..265	CDD:238060	8/61 (13%)
		LDLa	270..304	CDD:238060	8/33 (24%)
		LDLa	311..343	CDD:197566	11/50 (22%)
		FXa_inhibition	358..393	CDD:291342	12/44 (27%)
		EGF_CA	395..434	CDD:214542	14/42 (33%)
		NHL	<471..622	CDD:302697
		NHL repeat	471..507	CDD:271320
		LDL-receptor class B 1	480..522
		LY	505..545	CDD:214531
		NHL repeat	510..550	CDD:271320
		LDL-receptor class B 2	523..565
		NHL repeat	555..589	CDD:271320
		LDL-receptor class B 3	566..609
		LY	590..632	CDD:214531
		NHL repeat	598..622	CDD:271320
		LDL-receptor class B 4	610..652
		LY	633..673	CDD:214531
		LDL-receptor class B 5	653..693
		FXa_inhibition	702..>729	CDD:291342
		LY	766..806	CDD:214531
		LDL-receptor class B 6	785..827
		LY	808..850	CDD:214531
		LDL-receptor class B 7	828..870
		LDL-receptor class B 8	871..914
		Ldl_recept_b	871..911	CDD:278487
		LY	895..937	CDD:214531
		LDL-receptor class B 9	915..956
		LY	938..979	CDD:214531
		LDL-receptor class B 10	957..998
		FXa_inhibition	1006..1043	CDD:291342
		NHL	<1085..1277	CDD:302697
		NHL repeat	1085..1123	CDD:271320
		LDL-receptor class B 11	1093..1135
		NHL repeat	1128..1161	CDD:271320
		LDL-receptor class B 12	1136..1178
		NHL repeat	1166..1203	CDD:271320
		LDL-receptor class B 13	1179..1222
		NHL repeat	1212..1244	CDD:271320
		LDL-receptor class B 14	1223..1263
		NHL repeat	1253..1277	CDD:271320
		LDL-receptor class B 15	1264..1306
		FXa_inhibition	1313..1348	CDD:291342
		LY	1379..1418	CDD:214531
		LDL-receptor class B 16	1397..1439
		LY	1420..1460	CDD:214531
		LDL-receptor class B 17	1440..1482
		LDL-receptor class B 18	1483..1526
		Ldl_recept_b	1483..1523	CDD:278487
		LY	1507..1547	CDD:214531
		LDL-receptor class B 19	1527..1568
		LY	1549..1589	CDD:214531
		LDL-receptor class B 20	1569..1610
		FXa_inhibition	1617..>1641	CDD:291342
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1659..1696
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1853..1905
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000