Protein Alignment CAPN6 and RIM13

DIOPT Version :9

• Sequence 1: NP_055104.2
• Gene: CAPN6 / 827
• HGNCID: 1483
• Length: 641
• Species: Homo sapiens
• Sequence 2: NP_013875.1
• Gene: RIM13 / 855186
• SGDID: S000004763
• Length: 727
• Species: Saccharomyces cerevisiae
• Alignment Length: 588
• Identity: 111/588 - (18%)
• Similarity: 191/588 - (32%)
• Gaps: 220/588 - (37%)

Human   176 ALDGLTI---TDIIVDFTGTLAETVDMQKGRY----TELVEEKYKL--------------FGELY 219
            ::||..:   ::.|.|..|.||..: :.||.|    :.:..:.|:|              |.:|:
Yeast   179 SVDGKQLSLKSNDISDKIGELALLL-VSKGTYSTDGSNISIDTYRLSGFLPEITQVNSYPFEKLW 242

Human   220 KTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTYTMTDI----RKIRLGERLVEVFSAEKVYMV 280
            | |.|..|......:.|:....::.   |::.|.|::.||    |.::|.:......:.|..|..
Yeast   243 K-FHKSNLCLMGAGTGNRSNDMIKP---LVENHDYSIIDITYDSRLVKLRDPRNSALNVEISYEQ 303

Human   281 RLRNPLGRQEWSGPWSEISEEWQQLTA------------SDRKNLGLVMSDDGEF---------- 323
            .|:|          :.::...|.|...            :.|.|...:::|...|
Yeast   304 YLKN----------FKQLYLNWNQEKLFKRSQVLHFRYDTSRYNKFSIVADKPLFHLVNNSKVTE 358

Human   324 --WMSLEDFC--------RNFHKLN------VCRNVNNPI------FGRK--------ELESVLG 358
              |:.||...        |:...||      :| .:..|:      .|.:        |.|.:|.
Yeast   359 TVWLLLESHLQDEGSQENRSVSFLNEAPECIIC-PIEPPVECGGNHIGLQLVKLRLDAETERLLY 422

Human   359 CWTVDDDPLMNRSGG-----CYNN-RDT-------------------------FLQNPQYIFTV- 391
            |::..::.....|..     |:.. :||                         |.|||.:...|
Yeast   423 CYSTTNNNFSIHSFSVVKEICFQRLKDTKSLFAKVLFSFPYEIEGKASFDTCNFFQNPTFELEVH 487

Human   392 PEDGHKVIM-----SLQQKDL---RTYRRMGRPDNYIIGFELFKVEMNRKFRLHHLYIQERAGTS 448
            .|..::|:|     |....||   :.|        |...:||.|..|   |..|:     :.|..
Yeast   488 SEQDYQVLMDAACISTSSHDLINIQVY--------YFNDYELIKPIM---FDNHY-----QPGQG 536

Human   449 TYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGY 513
            ...|.      ..|....|::|.:.:....::||             ||...:...|.|.|..|
Yeast   537 LKQDV------PILTNVKYMIVCSTYGPPASTEF-------------ELLASIRLSSSWRLISG- 581

Human   514 PKVVTQITVHSAEDLEKKYANETVNPYLVIKCG------------KEEVRSPVQKNTVHAIFDTQ 566
                  ||:.|...:...|      ||   .|.            |.::..|.:|      :.|.
Yeast   582 ------ITLRSVNLIYGTY------PY---HCRNRFHWKETSDKLKIQMTLPTKK------YSTN 625

Human   567 AIFYRRTTDIPIIVQVWNS---RKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGG---PTAKVKQ 625
            .:|.|       :|.|.:|   |..|:.|..:..|..  .:|::.::.   ..||   |..:|.:
Yeast   626 KLFIR-------VVPVESSARLRMRCNIFEPESALCV--YECQEYRTC---PSGGIVIPDLEVSR 678

Human   626 GHI 628
            .:|
Yeast   679 TNI 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAPN6	NP_055104.2	CysPc	13..351	CDD:128526	45/243 (19%)
		Domain III	344..495		36/204 (18%)
		Calpain_III	349..497	CDD:238132	35/195 (18%)
		C2_Calpain	514..639	CDD:176011	26/133 (20%)
RIM13	NP_013875.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810