Protein Alignment CAPN6 and capn5a

DIOPT Version :9

• Sequence 1: NP_055104.2
• Gene: CAPN6 / 827
• HGNCID: 1483
• Length: 641
• Species: Homo sapiens
• Sequence 2: NP_001073476.1
• Gene: capn5a / 563346
• ZFINID: ZDB-GENE-061103-214
• Length: 639
• Species: Danio rerio
• Alignment Length: 642
• Identity: 306/642 - (47%)
• Similarity: 431/642 - (67%)
• Gaps: 12/642 - (1%)

Human     5 LKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFY--NRLLPGKVVWKRPQDICDDPHLIVGN 67
            :|.|:.|::..|:::|.::..||.||.|..|:.|||.  |||  |||.||||:|:|:||||.|..
Zfish     5 VKPFEGQEFSALRKQCQQNHTLFEDPVFRAEDQSLFLQGNRL--GKVTWKRPKDLCEDPHLFVNG 67

Human    68 ISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGEWT 132
            ||.|.|.||:||:...|:|.|.||.:|:.|.|.||:.|:||||..|.|.||||||||||.||:|.
Zfish    68 ISAHDLNQGQLGNCWFVAACSSLASREALWQKVIPDWKDQEWDKNKPESYAGIFHFRFWRFGDWV 132

Human   133 EVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAETV 197
            .|||||.|||.||.|::..|...||||:||:||||||:.||||||||....|.:|||||.::|.:
Zfish   133 GVVIDDRLPTANGKLIYCHSNDSNEFWSALVEKAYAKMCGCYEALDGGNTADALVDFTGGVSEPM 197

Human   198 DMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTYTMTDIRKI 262
            |:.:|::.:..|.:::||..:.|...:||||.|||.:..|.:.|...|.||:|||.|.:||:||:
Zfish   198 DLLEGKFAQDEEARHQLFDRVLKVHNRGGLISCSIRATTQADMEARLDCGLVKGHAYAVTDVRKV 262

Human   263 RLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGLVMSDDGEFWMSL 327
            |||..|:..|.:||:.|:|:|||.|::.|:|.||:.||||::::..:|:.||:.:.|||||||..
Zfish   263 RLGSGLLAFFKSEKLSMIRMRNPWGQRGWNGAWSDSSEEWKRVSKGERERLGVTVEDDGEFWMDF 327

Human   328 EDFCRNFHKLNVCRNVNN---PIFGRKELESVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQYIF 389
            :|||::|..|.:||.:|.   .|....|.|.:.|||:..||||.||||||.|::.||||||||:|
Zfish   328 DDFCKHFTDLILCRLINTSYLSIHKTWEEEVMRGCWSRHDDPLRNRSGGCINHKTTFLQNPQYVF 392

Human   390 TVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTR 454
            .|.:...:|::.|||:|.|. |..|  :|..|||::.:||:||.:|:|.  ||:..|:|.||::|
Zfish   393 DVTKAEDEVLICLQQQDKRA-RAKG--ENMAIGFDIQRVELNRIYRMHS--IQKSVGSSIYINSR 452

Human   455 TVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQ 519
            :|||.|.||:|.||:||:.|..|...:||||||::||...:|||:|.|..:||....||||:|||
Zfish   453 SVFLRKDLKEGRYVIVPSTFDPGMPGDFLLRIFTDVPSDCKELTVDEPPQTCWTSCCGYPKLVTQ 517

Human   520 ITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWN 584
            :.|..|:.|:....:.:.:||::|.|..|:|||||.|:|....||.:|:|||:....||.:|::|
Zfish   518 VHVIRADGLKALDGDGSSDPYIIISCEGEKVRSPVHKDTQSPDFDVKAVFYRKKPKQPIRIQIYN 582

Human   585 SRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL 641
            .....|.|:|||||:.|.||.:.|.:|.|:.||........|.:|..:.:||.||.:
Zfish   583 KNLLSDSFMGQVTLNGDLSDLQQLHTLRLQDKGSRKNNDLPGLLSVSLTTSDVLTNI 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAPN6	NP_055104.2	CysPc	13..351	CDD:128526	171/342 (50%)
		Domain III	344..495		74/153 (48%)
		Calpain_III	349..497	CDD:238132	72/147 (49%)
		C2_Calpain	514..639	CDD:176011	49/124 (40%)
capn5a	NP_001073476.1	Peptidase_C2	27..341	CDD:279042	164/315 (52%)
		Calpain_III	354..490	CDD:279416	71/140 (51%)
		C2_Calpain	512..637	CDD:176011	49/124 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52844
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104867
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830