Protein Alignment CAPN6 and capn6

DIOPT Version :9

• Sequence 1: NP_055104.2
• Gene: CAPN6 / 827
• HGNCID: 1483
• Length: 641
• Species: Homo sapiens
• Sequence 2: XP_031747775.1
• Gene: capn6 / 100494450
• XenbaseID: XB-GENE-992087
• Length: 643
• Species: Xenopus tropicalis
• Alignment Length: 644
• Identity: 312/644 - (48%)
• Similarity: 444/644 - (68%)
• Gaps: 4/644 - (0%)

Human     1 MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDDPHLIV 65
            |..|.|..|.|.|.|||:||||:.:||.||.|...::||||::....::.||||:::|:||||.|
 Frog     1 MSSPDKQLKTQNYHELKKECIKNGKLFEDPEFPASDESLFYSKAPDLRIEWKRPKELCEDPHLFV 65

Human    66 GNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFGE 130
            ..||:|.|.|||||:...|:|.||||::::.|||.|.|.|:|||||::..:|||||||:||..|:
 Frog    66 DGISSHDLHQGRLGNCWFVAACSCLALKKALWTKVISNWKKQEWDPKRPHRYAGIFHFKFWCLGD 130

Human   131 WTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDFTGTLAE 195
            |.:|||||.||:::|:||:..|...||||:||||||||||.|.||||||....|.||||||.:.|
 Frog   131 WVDVVIDDRLPSVDGNLVYCHSNVKNEFWSALLEKAYAKLAGSYEALDGGNTADAIVDFTGAVTE 195

Human   196 TVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQEVETDWGLLKGHTYTMTDIR 260
            :.::.||.|...:.|:.|||.||.|.:..||||.|.|:..:..:.|..|.:||:|||.|::|.|:
 Frog   196 SFELDKGDYRTSLMEQTKLFQELLKVYRAGGLISCYIKPVSSNDMEAVTSYGLVKGHAYSVTAIK 260

Human   261 KIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLTASDRKNLGLVMSDDGEFWM 325
            |:.:|:|::...::.|::|:|:|||.|::||.|.||:.||||.:::.|::..|||.::|||||||
 Frog   261 KMPVGQRILCFGNSNKLFMIRMRNPWGKREWKGAWSDESEEWNKVSRSEKATLGLTVADDGEFWM 325

Human   326 SLEDFCRNFHKLNVCRNVNN---PIFGRKELESVLGCWTVDDDPLMNRSGGCYNNRDTFLQNPQY 387
            :.||:|.:|...:|||.:|.   ..:...:.|.|.|.|:.:.|||:||||||: |..||.|||||
 Frog   326 TFEDWCLSFTHADVCRILNTSYLSCYKTWKQEEVHGAWSKNTDPLLNRSGGCF-NETTFFQNPQY 389

Human   388 IFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVEMNRKFRLHHLYIQERAGTSTYID 452
            ||.|.:...:|::||||||.|.:::.|:.:|:|||||:||||:||::|:|.:..||:...|:||:
 Frog   390 IFEVRKKEDEVLISLQQKDQRIHKKDGKGNNFIIGFEIFKVELNREYRIHMISGQEKTLRSSYIN 454

Human   453 TRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVV 517
            .|.:||.|.|..|.||::||.|..|.:|.|:||:|::...:.|||.||.||:|||:|..|||:.|
 Frog   455 LRAIFLRKVLTHGRYVIIPTTFHPGISSSFILRLFTDESSRFRELLLDKPKVSCWSLLCGYPQRV 519

Human   518 TQITVHSAEDLEKKYANETVNPYLVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQV 582
            ||:.|...|.:|::...:..|.|::||..|:.:||.|.|.|..|.||.||||:|:....||.:||
 Frog   520 TQVLVRHVEGVERQGQMQEPNLYIMIKGEKQTIRSLVYKKTSTAKFDIQAIFFRKNISEPICIQV 584

Human   583 WNSRKFCDQFLGQVTLDADPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL 641
            |:||..||||||||.|...|:|.::.:.|.|..:.....:...|||:.||:|||||.||
 Frog   585 WDSRIICDQFLGQVLLAGSPTDSKEERRLQLHGRDSHGEERMPGHITIKVVSSDDLVEL 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAPN6	NP_055104.2	CysPc	13..351	CDD:128526	168/340 (49%)
		Domain III	344..495		70/153 (46%)
		Calpain_III	349..497	CDD:238132	70/147 (48%)
		C2_Calpain	514..639	CDD:176011	54/124 (44%)
capn6	XP_031747775.1	Peptidase_C2	27..341	CDD:395523	156/313 (50%)
		Calpain_III	361..489	CDD:395848	66/128 (52%)
		C2_Calpain	516..640	CDD:176011	53/123 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52844
OrthoDB	1	1.010	-	-		D66294at32523
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030