DRSC/TRiP Functional Genomics Resources

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Protein Alignment CAPNS1 and CalpA

DIOPT Version :9

Sequence 1:XP_005259352.1 Gene:CAPNS1 / 826 HGNCID:1481 Length:322 Species:Homo sapiens
Sequence 2:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster


Alignment Length:284 Identity:77/284 - (27%)
Similarity:108/284 - (38%) Gaps:99/284 - (34%)


- Green bases have known domain annotations that are detailed below.


Human    53 GGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSA 117
            |.||.|..|..|..:          |:|..|             :....||||..:||.||||..
  Fly   575 GYGGKADTITPGFPT----------PKPIDP-------------QKEGLRRLFDSIAGKDMEVDW 616

Human   118 TELMNILNK----------VVTRH-----------------------------PDLK-------- 135
            .||..||:.          |..|.                             |.||        
  Fly   617 MELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQL 681

Human   136 -----------------------------TDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNI 171
                                         |.||..|.||||||::|:|.:||||||||:.|.:.|
  Fly   682 GMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEI 746

Human   172 KRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRL 236
            .:|:||:|.:|.:.:|.:...:|..|..:||:|||..:.|::..||....|.:.||:||.|.|::
  Fly   747 AKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKI 811

Human   237 DAMFRAFKSLDKDGTGQIQVNIQE 260
            ......||..|.:........::|
  Fly   812 KTYIDIFKERDTEKNETATFTLEE 835

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CAPNS1XP_005259352.1 EFh_PEF_CPNS1_2 100..260 CDD:320063 67/235 (29%)
EF-hand motif 100..128 CDD:320063 14/37 (38%)
EF-hand motif 142..172 CDD:320063 18/29 (62%)
EF-hand motif 173..203 CDD:320063 9/29 (31%)
EF-hand motif 209..237 CDD:320063 10/27 (37%)
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:279042
Calpain_III 418..565 CDD:279416
EFh 719..765 CDD:238008 24/45 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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