DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAPNS1 and CalpC

DIOPT Version :9

Sequence 1:	XP_005259352.1	Gene:	CAPNS1 / 826	HGNCID:	1481	Length:	322	Species:	Homo sapiens
Sequence 2:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	207	Identity:	56/207 - (27%)
Similarity:	98/207 - (47%)	Gaps:	11/207 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    59 MRILGGVISAISEAAAQ----YNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATE 119
            :||||.....:|....|    .:|.|....|........:.:.|.|:..::.|||.::..::..|
  Fly   470 VRILGTGSFRLSCLETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFE 534

Human   120 LMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTD 184
            |..:|...:..  |.......||.||.::|:.|...:|::.|::||....|:|.||.::|.:..:
  Fly   535 LHELLEACLPN--DYIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKE 597

Human   185 RSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKD 249
            ::|.:.:..|..|....||.|:..:.|.:|:||..:.|.:...:|:|.::.|...|..| .|...
  Fly   598 KAGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQF-HLKNY 661

Human   250 GTGQIQVNIQEV 261
            |    |||:.||
  Fly   662 G----QVNVIEV 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAPNS1	XP_005259352.1	EFh_PEF_CPNS1_2	100..260	CDD:320063	44/159 (28%)
		EF-hand motif	100..128	CDD:320063	7/27 (26%)
		EF-hand motif	142..172	CDD:320063	10/29 (34%)
		EF-hand motif	173..203	CDD:320063	6/29 (21%)
		EF-hand motif	209..237	CDD:320063	7/27 (26%)
CalpC	NP_573118.2	CysPc	7..329	CDD:238004
		Calpain_III	346..483	CDD:238132	5/12 (42%)
		FRQ1	<567..648	CDD:227455	22/80 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910