DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YAO and U3-55K

DIOPT Version :9

Sequence 1:	NP_192450.1	Gene:	YAO / 825889	AraportID:	AT4G05410	Length:	504	Species:	Arabidopsis thaliana
Sequence 2:	NP_001014529.1	Gene:	U3-55K / 3346176	FlyBaseID:	FBgn0053505	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	163/506 - (32%)
Similarity:	264/506 - (52%)	Gaps:	63/506 - (12%)

- Green bases have known domain annotations that are detailed below.

plant     9 KGGSFKRGGKKGSN---ERDPFFEEEPKKRRKVSYDDDDIESVDSDAEENGFTGGDEDGRRVDGE 70
            ||...|:|||.|.:   ...|.    |||:|:...:|::|.|  .|.|.|...|||::....
  Fly    25 KGKPLKKGGKPGKSTPAAGGPV----PKKQRRPKEEDEEIAS--DDEEYNSDLGGDDNTLAF--- 80

plant    71 VEDEDEFADETAGEKRKRLAEEMLNRRREAMRREREEADNDDDDDEDDDETIKKSLMQKQQEDSG 135
              ..||..:||..:||.|||::.|:   |..::|.|.|     :|.:..:::::.|..:..:..|
  Fly    81 --SSDEGEEETPQDKRLRLAKQYLS---EIEKQEAERA-----EDRELAQSVEQRLQTEYLDSVG 135

plant   136 RIRRLIASRVQEPLSTDGFSVIVKHR---RSVVSVALSDDDSRGFSASKDGTIMHWDVSSGKTDK 197
            ::||.||..::...|    |.|:||:   ..:.::|||.|....::.:|...::.|...:||.
  Fly   136 KLRRNIAGSLKACES----SRILKHKLHHTPICALALSPDGKFLYTGAKSQFLLKWCTETGKV-- 194

plant   198 YIWPSDEILKSHGMKLREPRNKNHSRES--LALAVSSDGRYLATGGVDRHVHIWDVRTREHVQAF 260
                   :.||..:..||.......|.|  :::.:|||.:|||......|:.||..:|.:|::..
  Fly   195 -------LEKSDVLSHREEPETGKKRRSHVISICLSSDMKYLALAEGGPHIQIWCPQTMKHIKTL 252

plant   261 PGHRNTVSCLCFRYGTSELYSGSFDRTVKVWNVEDKAFITENHGHQGEILAIDALRKERALTV-G 324
            .|||::|:.|.||.||.:|||.:.||:||:|::::.|::....|||..:.:||||.:|||:|. |
  Fly   253 KGHRDSVAGLVFRKGTHDLYSAAKDRSVKIWSLDEMAYVESLFGHQTAVTSIDALSRERAITAGG 317

plant   325 RDRTMLYHKVPESTRMIYRAPASSLESCCFISDNEYLSGSDNGTVALWGMLKKKPVFVFKNAHQD 389
            .|.::...|:.|.:::||.....|:|...:|:|..::||..:|.:.||..|||||:...:.||
  Fly   318 SDCSLRIWKITEESQLIYNGHKDSIECVKYINDEHFVSGGMDGAIGLWSALKKKPICTTQLAH-- 380

plant   390 IPDGITTNGILENGDHEPVNNNCSANSWVNAVATSRGSDLAASGAGNGFVRLWAVETNA--IRPL 452
               |:..||:              || |:.|:|....:||.|:|:.:|.||||....||  :..:
  Fly   381 ---GVGENGV--------------AN-WITAIAVVVNTDLVATGSCDGCVRLWQTNPNARKMNLI 427

plant   453 YELPLTGFVNSLAFAKSGKFLIAGVGQETRFGRWGCLKSAQNGVAIHPLRL 503
            ..:.:.||:|.|||...|..|....|||.|.|||..||.|:|.|.:..::|
  Fly   428 QSISIAGFINGLAFNADGSKLFVATGQEHRLGRWWRLKEAKNQVVVLDVKL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YAO	NP_192450.1	WD40	156..476	CDD:421866	106/327 (32%)
		WD40 repeat	164..202	CDD:293791	8/37 (22%)
		WD40 repeat	226..262	CDD:293791	11/35 (31%)
		WD40 repeat	267..301	CDD:293791	15/33 (45%)
		WD40 repeat	310..342	CDD:293791	12/32 (38%)
		WD40 repeat	349..401	CDD:293791	18/51 (35%)
		WD40 repeat	418..458	CDD:293791	13/41 (32%)
U3-55K	NP_001014529.1	Upf2	55..>125	CDD:281974	24/84 (29%)
		WD40	<150..484	CDD:225201	121/362 (33%)
		WD40	156..416	CDD:295369	93/288 (32%)
		WD40 repeat	163..203	CDD:293791	10/48 (21%)
		WD40 repeat	218..254	CDD:293791	11/35 (31%)
		WD40 repeat	259..295	CDD:293791	15/35 (43%)
		WD40 repeat	302..336	CDD:293791	13/33 (39%)
		WD40 repeat	342..379	CDD:293791	13/36 (36%)
		WD40 repeat	391..431	CDD:293791	13/39 (33%)
		WD40 repeat	436..461	CDD:293791	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	46	1.000	Domainoid score	I4603
eggNOG	1	0.900	-	-		E1_KOG0299
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3452
Inparanoid	1	1.050	242	1.000	Inparanoid score	I1072
OMA	1	1.010	-	-		QHG54739
OrthoDB	1	1.010	-	-		D948159at2759
OrthoFinder	1	1.000	-	-		FOG0004346
OrthoInspector	1	1.000	-	-		otm3093
orthoMCL	1	0.900	-	-		OOG6_102033
Panther	1	1.100	-	-	O	PTHR19865
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3065
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840