Protein Alignment CAPN3 and capn3

DIOPT Version :10

• Sequence 1: NP_000061.1
• Gene: CAPN3 / 825
• HGNCID: 1480
• Length: 821
• Species: Homo sapiens
• Sequence 2: XP_002935381.2
• Gene: capn3 / 100497532
• XenbaseID: XB-GENE-5875739
• Length: 805
• Species: Xenopus tropicalis
• Alignment Length: 807
• Identity: 601/807 - (74%)
• Similarity: 690/807 - (85%)
• Gaps: 19/807 - (2%)

Human    26 PAQSKATEAG---------GGNP-SGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLYVDPEF 80
            |.|::.||:|         |..| .||||||||||.||||.:|||||:|.||||::...:.|.||
 Frog     7 PEQAQKTESGSAVTGGASDGAAPGGGIYSAIISRNLPIIGGREKTFEELRKKCLQRNFHFQDREF 71

Human    81 PPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLL 145
            ||||:||||||.|||:|.|||||||||||:||:.||||||||||:||||||||||||||||:.:|
 Frog    72 PPDESSLFYSQSFPIKFEWKRPPEICENPQFILGGANRTDICQGDLGDCWFLAAIACLTLNEKVL 136

Human   146 FRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYA 210
            |||||.||:|.:||||||||||||||:||||:|||.||||||:||||||:.||||||||||||||
 Frog   137 FRVIPPDQNFTDNYAGIFHFQFWRYGDWVDVIIDDYLPTYNNELVFTKSSQRNEFWSALLEKAYA 201

Human   211 KLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYG 275
            |||||||||||||||||||||||||.||:|:::||.|||.|||||.|||||:||||||....:.|
 Frog   202 KLHGSYEALKGGNTTEAMEDFTGGVTEFYELKEAPKDMYNIMKKAFERGSLIGCSIDDKYGSSCG 266

Human   276 TSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTG 340
            .:|.. ||.:.|.:|:.::.::   ..|.:.||...:|..|::|||.|||||.|||:||||||||
 Frog   267 FAPPS-NMEDAIMKMIESVGDT---RPDTNGRGQPPKPVATLVPVQLETRMANGLVKGHAYSVTG 327

Human   341 LDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFI 405
            ::|...||:.:||||||||||||||||:|.|..|:|:.|||.||.||||||.|||||||||:||:
 Frog   328 VEETKLKGKPIKLVRLRNPWGQVEWNGAWGDNAKEWTMVDKSEKTRLQHQVQEDGEFWMSYDDFM 392

Human   406 YHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDD 470
            .:|||.||||||.|||.||.||.|||||||||||||||||||||:|||:||||||||||||||||
 Frog   393 KNFTKAEICNLTPDALDSDSLQVWTVSVNEGRWVRGCSAGGCRNYPDTYWTNPQYRLKLLEEDDD 457

Human   471 PDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSK 535
            |.|:||:|||:|||||||||||||.||:||||||||||||||||||.|||||||||||||||:.|
 Frog   458 PADNEVVCSFVVALMQKNRRKDRKAGANLFTIGFAIYEVPKEMHGNNQHLQKDFFLYNASKAKCK 522

Human   536 TYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV-KKKKT 599
            :|||||||.||||||||||||:||||||||||||||||||||||:||||||.|..::|: ||||.
 Frog   523 SYINMREVCQRFRLPPSEYVIIPSTYEPHQEGEFILRVFSEKRNISEEVENKIEAEKPIKKKKKP 587

Human   600 KPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGD 664
            |||||||||:||||||.||..::|.:.|...:|:.::    ..|:|.|:||::||||||:|||||
 Frog   588 KPIIFVSDRSNSNKELNVDGATDEDQKKMDAEKKDKT----SASTDTETEEEKQFRNIFQQIAGD 648

Human   665 DMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQK 729
            ||||.||||:.|||.||||||.||:.||||||||||||||||||.|:||||||:|||.|||.|||
 Frog   649 DMEISADELQSVLNNVVNKHKTLKSSGFTLESCRSMIALMDTDGCGRLNLQEFYHLWQKIKQWQK 713

Human   730 IFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFR 794
            ||..:|:||||||:|:|||||:|:||||||||||||||||||:|.|::|||||||||||||||||
 Frog   714 IFLRFDSDQSGTISSFEMRNAINEAGFHLNNQLYDIITMRYANKRMDLDFDSFICCFVRLEGMFR 778

Human   795 AFHAFDKDGDGIIKLNVLEWLQLTMYA 821
            |||||||||||||||||||||||||||
 Frog   779 AFHAFDKDGDGIIKLNVLEWLQLTMYA 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAPN3	NP_000061.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	7..37		5/19 (26%)
		Peptidase_C2	75..415	CDD:459889	241/339 (71%)
		Domain III	418..586		148/167 (89%)
		Calpain_III	435..574	CDD:460050	124/138 (90%)
		Calpain_u2	583..653	CDD:465216	35/70 (50%)
		Linker	587..649		29/62 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	609..652		16/42 (38%)
		Domain IV	650..821		143/170 (84%)
		EFh_PEF_CAPN3	653..821	CDD:320065	142/167 (85%)
		EF-hand motif	653..681	CDD:320065	22/27 (81%)
		EF-hand motif	696..725	CDD:320065	24/28 (86%)
		EF-hand motif	726..756	CDD:320065	20/29 (69%)
		EF-hand motif	761..790	CDD:320065	24/28 (86%)
		EF-hand motif	791..821	CDD:320065	29/29 (100%)
capn3	XP_002935381.2	Peptidase_C2	66..402	CDD:459889	241/339 (71%)
		Calpain_III	422..561	CDD:460050	124/138 (90%)
		Calpain_u2	570..637	CDD:465216	35/70 (50%)
		EFh_PEF_CAPN3	637..805	CDD:320065	142/167 (85%)
		EF-hand motif	637..665	CDD:320065	22/27 (81%)
		EF-hand motif	680..709	CDD:320065	24/28 (86%)
		EF-hand motif	710..740	CDD:320065	20/29 (69%)
		EF-hand motif	745..774	CDD:320065	24/28 (86%)
		EF-hand motif	775..805	CDD:320065	29/29 (100%)