DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAPN3 and capn3

DIOPT Version :9

Sequence 1:	NP_000061.1	Gene:	CAPN3 / 825	HGNCID:	1480	Length:	821	Species:	Homo sapiens
Sequence 2:	XP_002935381.2	Gene:	capn3 / 100497532	XenbaseID:	XB-GENE-5875739	Length:	805	Species:	Xenopus tropicalis

Alignment Length:	807	Identity:	601/807 - (74%)
Similarity:	690/807 - (85%)	Gaps:	19/807 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    26 PAQSKATEAG---------GGNP-SGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLYVDPEF 80
            |.|::.||:|         |..| .||||||||||.||||.:|||||:|.||||::...:.|.||
Frog     7 PEQAQKTESGSAVTGGASDGAAPGGGIYSAIISRNLPIIGGREKTFEELRKKCLQRNFHFQDREF 71

Human    81 PPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLL 145
            ||||:||||||.|||:|.|||||||||||:||:.||||||||||:||||||||||||||||:.:|
Frog    72 PPDESSLFYSQSFPIKFEWKRPPEICENPQFILGGANRTDICQGDLGDCWFLAAIACLTLNEKVL 136

Human   146 FRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYA 210
            |||||.||:|.:||||||||||||||:||||:|||.||||||:||||||:.||||||||||||||
Frog   137 FRVIPPDQNFTDNYAGIFHFQFWRYGDWVDVIIDDYLPTYNNELVFTKSSQRNEFWSALLEKAYA 201

Human   211 KLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYG 275
            |||||||||||||||||||||||||.||:|:::||.|||.|||||.|||||:||||||....:.|
Frog   202 KLHGSYEALKGGNTTEAMEDFTGGVTEFYELKEAPKDMYNIMKKAFERGSLIGCSIDDKYGSSCG 266

Human   276 TSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTG 340
            .:|.. ||.:.|.:|:.::.::   ..|.:.||...:|..|::|||.|||||.|||:||||||||
Frog   267 FAPPS-NMEDAIMKMIESVGDT---RPDTNGRGQPPKPVATLVPVQLETRMANGLVKGHAYSVTG 327

Human   341 LDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFI 405
            ::|...||:.:||||||||||||||||:|.|..|:|:.|||.||.||||||.|||||||||:||:
Frog   328 VEETKLKGKPIKLVRLRNPWGQVEWNGAWGDNAKEWTMVDKSEKTRLQHQVQEDGEFWMSYDDFM 392

Human   406 YHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDD 470
            .:|||.||||||.|||.||.||.|||||||||||||||||||||:|||:||||||||||||||||
Frog   393 KNFTKAEICNLTPDALDSDSLQVWTVSVNEGRWVRGCSAGGCRNYPDTYWTNPQYRLKLLEEDDD 457

Human   471 PDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSK 535
            |.|:||:|||:|||||||||||||.||:||||||||||||||||||.|||||||||||||||:.|
Frog   458 PADNEVVCSFVVALMQKNRRKDRKAGANLFTIGFAIYEVPKEMHGNNQHLQKDFFLYNASKAKCK 522

Human   536 TYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPV-KKKKT 599
            :|||||||.||||||||||||:||||||||||||||||||||||:||||||.|..::|: ||||.
Frog   523 SYINMREVCQRFRLPPSEYVIIPSTYEPHQEGEFILRVFSEKRNISEEVENKIEAEKPIKKKKKP 587

Human   600 KPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGD 664
            |||||||||:||||||.||..::|.:.|...:|:.::    ..|:|.|:||::||||||:|||||
Frog   588 KPIIFVSDRSNSNKELNVDGATDEDQKKMDAEKKDKT----SASTDTETEEEKQFRNIFQQIAGD 648

Human   665 DMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQK 729
            ||||.||||:.|||.||||||.||:.||||||||||||||||||.|:||||||:|||.|||.|||
Frog   649 DMEISADELQSVLNNVVNKHKTLKSSGFTLESCRSMIALMDTDGCGRLNLQEFYHLWQKIKQWQK 713

Human   730 IFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFR 794
            ||..:|:||||||:|:|||||:|:||||||||||||||||||:|.|::|||||||||||||||||
Frog   714 IFLRFDSDQSGTISSFEMRNAINEAGFHLNNQLYDIITMRYANKRMDLDFDSFICCFVRLEGMFR 778

Human   795 AFHAFDKDGDGIIKLNVLEWLQLTMYA 821
            |||||||||||||||||||||||||||
Frog   779 AFHAFDKDGDGIIKLNVLEWLQLTMYA 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAPN3	NP_000061.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	7..37		5/19 (26%)
		Peptidase_C2	75..415	CDD:279042	241/339 (71%)
		Domain III	418..586		148/167 (89%)
		Calpain_III	429..579	CDD:279416	135/149 (91%)
		Calpain_u2	583..653	CDD:293254	35/70 (50%)
		Linker	587..649		29/62 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	609..652		16/42 (38%)
		Domain IV	650..821		143/170 (84%)
		EFh	653..721	CDD:238008	56/67 (84%)
		EFh	697..751	CDD:238008	42/53 (79%)
		EFh	728..817	CDD:298682	76/88 (86%)
		EF-hand_7	728..784	CDD:290234	43/55 (78%)
capn3	XP_002935381.2	Peptidase_C2	66..402	CDD:279042	241/339 (71%)
		Calpain_III	416..566	CDD:279416	135/149 (91%)
		Calpain_u2	570..637	CDD:293254	35/70 (50%)
		EFh	648..706	CDD:298682	47/57 (82%)
		EFh	681..735	CDD:238008	42/53 (79%)
		EFh	712..801	CDD:298682	76/88 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	527	1.000	Domainoid score	I3301
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52
Inparanoid	1	1.050	1235	1.000	Inparanoid score	I2129
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48339
OrthoDB	1	1.010	-	-		D56952at32523
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	1	1.000	-	-		oto150959
Panther	1	1.100	-	-	LDO	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.080