Protein Alignment SMC1A and SMC1

DIOPT Version :10

• Sequence 1: NP_006297.2
• Gene: SMC1A / 8243
• HGNCID: 11111
• Length: 1233
• Species: Homo sapiens
• Sequence 2: NP_116647.1
• Gene: SMC1 / 850540
• SGDID: S000001886
• Length: 1225
• Species: Saccharomyces cerevisiae
• Alignment Length: 1288
• Identity: 402/1288 - (31%)
• Similarity: 701/1288 - (54%)
• Gaps: 126/1288 - (9%)

Human     1 MGFLKLIEIENFKSYKGRQIIGPF--QRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRD 63
            ||.|..:|:.|||||:|...:| |  ..||:|||||||||||:|||||||||.::::||...|:|
Yeast     1 MGRLVGLELSNFKSYRGVTKVG-FGESNFTSIIGPNGSGKSNMMDAISFVLGVRSNHLRSNILKD 64

Human    64 LIH---------------GAPVGKPAANRAFVSMVYSEEGAEDRTFARVIV-GGSSEYKINNKVV 112
            ||:               ||....|.:  |:|...| ::|.:.....|:|. .|.:.|||:.|.|
Yeast    65 LIYRGVLNDENSDDYDNEGAASSNPQS--AYVKAFY-QKGNKLVELMRIISRNGDTSYKIDGKTV 126

Human   113 QLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVK 177
            ...:||..||...|||||:|||||||.||.||.::|.|.:.:|||:|.|.:..:||::.|:::.|
Yeast   127 SYKDYSIFLENENILIKAKNFLVFQGDVEQIAAQSPVELSRMFEEVSGSIQYKKEYEELKEKIEK 191

Human   178 AEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKEL 242
            ..:....:...::.|..|.|..|:...:.:.|::..|:....|....|::|||.|.:.|:|..:|
Yeast   192 LSKSATESIKNRRRIHGELKTYKEGINKNEEYRKQLDKKNELQKFQALWQLYHLEQQKEELTDKL 256

Human   243 ASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKE-------IKEKDSELNQKR----P 296
            ::.|.||...|   .|:.:|:|..::.....::|...|.|:       .|:|:..::..|    |
Yeast   257 SALNSEISSLK---GKINNEMKSLQRSKSSFVKESAVISKQKSKLDYIFKDKEKLVSDLRLIKVP 318

Human   297 QYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQ 361
            |....| ..||..|::|:.:|.||. ||.|.:|      .|.::..|.::::.|||.:::.:::.
Yeast   319 QQAAGK-RISHIEKRIESLQKDLQR-QKTYVER------FETQLKVVTRSKEAFEEEIKQSARNY 375

Human   362 GRDLTLEENQVKKYHRLKEE-ASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKL 425
            .: ..|.||.:|.|:.|.|: .::..:.|.:::...|.|::..|     ||.::....|.| .|.
Yeast   376 DK-FKLNENDLKTYNCLHEKYLTEGGSILEEKIAVLNNDKREIQ-----EELERFNKRADI-SKR 433

Human   426 REIEENQKRIEKLEEYITTSKQSLEEQKKLEGE-------LTEEVEMAKRRIDEINKELNQVMEQ 483
            |..||.....|||:..:...:.||.|:..|..|       |..::|.|..:..::|.:|.:.:.:
Yeast   434 RITEELSITGEKLDTQLNDLRVSLNEKNALHTERLHELKKLQSDIESANNQEYDLNFKLRETLVK 498

Human   484 LGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVD 548
            :.|...:::|:.::::..|.:..:||.:|| |.|.:.|||.|.::||.:||:.:||||.|::||:
Yeast   499 IDDLSANQRETMKERKLRENIAMLKRFFPG-VKGLVHDLCHPKKEKYGLAVSTILGKNFDSVIVE 562

Human   549 SEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYAC 613
            :....::||.::|:||....:|:|||.:|.:.....|.:.:...|.|:.|.|||.: :||:||.|
Yeast   563 NLTVAQECIAFLKKQRAGTASFIPLDTIETELPTLSLPDSQDYILSINAIDYEPEY-EKAMQYVC 626

Human   614 GNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGAS-DLKAKARRWDEKAVDKLKEK 677
            |::::|:.:..|:.:.:....|.|.|.::|.|..|:|:::||.| |..   .|||::....|...
Yeast   627 GDSIICNTLNIAKDLKWKKGIRGKLVTIEGALIHKAGLMTGGISGDAN---NRWDKEEYQSLMSL 688

Human   678 KERLTEELKEQMKAKRKEA-ELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESEL 741
            |::|..::.|....:|..: ..|:|::....|...:...::.:.|.| |.|     ::::||.:.
Yeast   689 KDKLLIQIDELSNGQRSNSIRAREVENSVSLLNSDIANLRTQVTQQK-RSL-----DENRLEIKY 747

Human   742 AN------FGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQ 800
            .|      ..|:|.::|:.:...|....:|.::...:::.:|:||..:||. .|:|:|....:..
Yeast   748 HNDLIEKEIQPKITELKKKLDDLENTKDNLVKEKEALQNNIFKEFTSKIGF-TIKEYENHSGELM 811

Human   801 NEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDEN-EIEKLKKEEQRH---MK 861
            .:.:|:..:.:.|...:..:|.||.::|...|.:   :|:..|..|| ::|....|||.:   ||
Yeast   812 RQQSKELQQLQKQILTVENKLQFETDRLSTTQRR---YEKAQKDLENAQVEMKSLEEQEYAIEMK 873

Human   862 I------IDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLE 920
            |      ::|....|.:|:.:.:.|:||:|.....:|::       |..:..|::|...|:..:|
Yeast   874 IGSIESKLEEHKNHLDELQKKFVTKQSELNSSEDILEDM-------NSNLQVLKRERDGIKEDIE 931

Human   921 QKRSDRHNLLQACKMQDIKLPL-SKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYG 984
            :...:|...|:.||:.:|.:|: |:.|:||:..   ||...::::.|..          |:|:|.
Yeast   932 KFDLERVTALKNCKISNINIPISSETTIDDLPI---SSTDNEAITISNS----------IDINYK 983

Human   985 DLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAAR 1049
            .|.:..|:...:...|:    |:||::|.:.:|..: .||.:|:|:.:....:|:..::|.|..:
Yeast   984 GLPKKYKENNTDSARKE----LEQKIHEVEEILNEL-QPNARALERYDEAEGRFEVINNETEQLK 1043

Human  1050 KRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRN-------SSAQAFLGPENPEEPY 1107
            ...||....|.:|||:|.:.|...|:.|:.::|.||:.|::|       :...|.|..|:.:||:
Yeast  1044 AEEKKILNQFLKIKKKRKELFEKTFDYVSDHLDAIYRELTKNPNSNVELAGGNASLTIEDEDEPF 1108

Human  1108 LDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVAN 1172
            ..||.|:...|.|||:.|:.|||||||||||||||||:||:|:|||||||:|||||.||:.::|.
Yeast  1109 NAGIKYHATPPLKRFKDMEYLSGGEKTVAALALLFAINSYQPSPFFVLDEVDAALDITNVQRIAA 1173

Human  1173 YIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKYPD 1225
            ||:.....:.|.||||||...:.|:::|:|||.:|.: ..||::|.||:.|.:
Yeast  1174 YIRRHRNPDLQFIVISLKNTMFEKSDALVGVYRQQQE-NSSKIITLDLSNYAE 1225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1A	NP_006297.2	SMC_N	3..1210	CDD:426784	394/1269 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..308		7/27 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..369		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..966		4/18 (22%)
SMC1	NP_116647.1	SMC_N	4..1209	CDD:426784	393/1266 (31%)