Protein Alignment SMC1A and SMC1

DIOPT Version :10

• Sequence 1: NP_006297.2
• Gene: SMC1A / 8243
• HGNCID: 11111
• Length: 1233
• Species: Homo sapiens
• Sequence 2: NP_651211.2
• Gene: SMC1 / 42853
• FlyBaseID: FBgn0040283
• Length: 1238
• Species: Drosophila melanogaster
• Alignment Length: 1229
• Identity: 606/1229 - (49%)
• Similarity: 869/1229 - (70%)
• Gaps: 23/1229 - (1%)

Human     3 FLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIHG 67
            ||:.||:||||||:|..::||.::|.|:||||||||||.|||||||:|||||:||||.|.|||||
  Fly    26 FLEYIEMENFKSYRGHIVVGPLKQFNAVIGPNGSGKSNFMDAISFVMGEKTSSLRVKRLNDLIHG 90

Human    68 APVGKPAANRAFVS--MVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKA 130
            :.:|||.:...:|:  .|.:||...|  |.|.::||||||:||.:.|....|..:|||:||.:||
  Fly    91 SSIGKPVSRSCYVTAKFVLNEERHMD--FQRAVIGGSSEYRINGESVSSSTYLNKLEKIGINVKA 153

Human   131 RNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAE 195
            :||||||||||:||||.||||||||||||.||.|..:|::.|:||:.|||:|||.|.:||.||||
  Fly   154 KNFLVFQGAVENIAMKTPKERTALFEEISGSGLLKDDYNRLKQEMIVAEEETQFTYQKKKGIAAE 218

Human   196 RKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVE 260
            |||||.||.|||||.||::|....||:.|||:|:|.|.:|.|...:|..:.:|::..::|.:..:
  Fly   219 RKEAKHEKMEADRYTRLQNEYNEKQVEYQLFRLFHVERDIRKFTSDLEVRQQEVKAVEQRKEAAD 283

Human   261 DELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKH 325
            :.|:||||:.||:.|:..:|::||:|.::::|::||.||||||..:|..|||.:.:|:|:.|::.
  Fly   284 EILREKKKDAGKITRDLAKIDQEIREFETQMNKRRPLYIKAKEKVTHCKKKLISLQKTLETAREA 348

Human   326 YKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLA 390
            ....:.|:.:|||::..||..::.||:.:|.|||.:|:.:.:||..|::|.|||:||...|....
  Fly   349 DNAHQSDIRKLEKQLADVEALKKRFEDEIENESQRRGKSVNMEEGLVQEYDRLKQEAEATATQYR 413

Human   391 QELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKL 455
            .||:..||:||::||.||.|..::...|...|:...:.||..||.:||.::|.:|:.:||||.::
  Fly   414 SELDSVNREQKSEQDTLDGETNRRASVEESFKKLTLQREEAVKRRDKLMDHIKSSQAALEEQNRI 478

Human   456 EGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLI 520
            :.||..:|..:|.:|.|..:||..|.:|||||:.|:.|.:|:::|.|::|..|:..|| ||.|:|
  Fly   479 KDELRRDVGTSKEKIAEKQRELEDVRDQLGDAKSDKHEDARRKKKQEVVELFKKQVPG-VYDRMI 542

Human   521 DLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKL 585
            ::||||.|:|.:||||||||.|:|||||:|||.|.|||.:|||..|.|||||||||:|||..|:|
  Fly   543 NMCQPTHKRYNVAVTKVLGKFMEAIIVDTEKTARHCIQILKEQMLEVETFLPLDYLQVKPLKERL 607

Human   586 REL---KGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVEDARRIAFG-GHQRHKTVALDGTLF 646
            |.:   :..:||.||:::||..|::|:.:|.||||||:..|||.::|:. ...|...:|||||.:
  Fly   608 RNISDPRNVRLVFDVLKFEPQEIERAVLFATGNALVCETPEDAMKVAYEIDRSRFDALALDGTFY 672

Human   647 QKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMR 711
            ||||:||||:.||..||:|||||.:.:||.:||||.|||||.:|..||::||..|:||..||:.|
  Fly   673 QKSGLISGGSHDLARKAKRWDEKHMAQLKMQKERLQEELKELVKKSRKQSELATVESQIKGLENR 737

Human   712 LKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEV 776
            ||||..|||.:| :.::....:..:::|:|..|||:|.:|:|.:|:||..::::||.||.|||:|
  Fly   738 LKYSMVDLESSK-KSISQYDNQLQQVQSQLDEFGPKILEIERRMQNREEHIQEIKENMNNVEDKV 801

Human   777 FEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQT 841
            :..|||.:||:|||::||.::..|.|.|:||.|||.|...:..||||||.  |:.:..|..||::
  Fly   802 YASFCRRLGVKNIRQYEERELVMQQERARKRAEFEQQIDSINSQLDFEKQ--KDTKKNVERWERS 864

Human   842 VKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMT 906
            |:.:|:.:|.||..|.|::|.|||...:::..|....|||..|:|...::.:.||.:....||:.
  Fly   865 VQDEEDALEGLKLAEARYLKEIDEDKEKMEKFKQDKQAKKQAVDDMEEDISKARKDVANLAKEIH 929

Human   907 HLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISS 971
            ::...::|:|:|:|.|:::|.|:|...|...|.:||.:|::||..:     |.:..|.     |:
  Fly   930 NVGSHLSAVESKIEAKKNERQNILLQAKTDCIVVPLLRGSLDDAVR-----QSDPDVP-----ST 984

Human   972 IYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRD 1036
            ..|.|.:||:||..|..:....:.:...|:....||:.|..:..||:||..|||||::||::|.:
  Fly   985 SAAMENIIEVDYSSLPREYTKLKDDSAFKKTHEMLQKDLQSKLDVLERIQTPNMKALQKLDAVTE 1049

Human  1037 KFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPE 1101
            |.|.|::|||.|||:||:||.|||::|.||..||.||.:.::..||.|||.|:||.:|||::||:
  Fly  1050 KVQSTNEEFENARKKAKRAKAAFERVKNERSSRFVACCQHISDAIDGIYKKLARNEAAQAYIGPD 1114

Human  1102 NPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTN 1166
            |||||||||||||||||||||:||:||||||||:|||||||:.||:.||||||||||||||||||
  Fly  1115 NPEEPYLDGINYNCVAPGKRFQPMNNLSGGEKTIAALALLFSTHSFHPAPFFVLDEIDAALDNTN 1179

Human  1167 IGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKYPD 1225
            |||||:||::.:| |.|.||||||||||..|::|:|:.|.:|||::|.|...|||.:.|
  Fly  1180 IGKVASYIRDHTT-NLQTIVISLKEEFYGHADALVGITPGEGDCLVSNVYIMDLTTFED 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1A	NP_006297.2	SMC_N	3..1210	CDD:426784	598/1212 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..308		11/23 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..369		7/20 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..966		4/18 (22%)
SMC1	NP_651211.2	SMC_N	26..1222	CDD:481474	598/1212 (49%)