Protein Alignment SMC1A and psm1

DIOPT Version :10

• Sequence 1: NP_006297.2
• Gene: SMC1A / 8243
• HGNCID: 11111
• Length: 1233
• Species: Homo sapiens
• Sequence 2: NP_596049.2
• Gene: psm1 / 2540557
• PomBaseID: SPBC29A10.04
• Length: 1228
• Species: Schizosaccharomyces pombe
• Alignment Length: 1289
• Identity: 449/1289 - (34%)
• Similarity: 740/1289 - (57%)
• Gaps: 129/1289 - (10%)

Human     1 MGFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLI 65
            ||.|..:|:||||||:|.||||||:.||:||||||:||||||||||||||.|:|:||...:::||
pombe     1 MGRLLRLEVENFKSYRGHQIIGPFEDFTSIIGPNGAGKSNLMDAISFVLGVKSSHLRSTNVKELI 65

Human    66 HGAPV-----------GKPAANRAFVSMVYSEEGAEDRTFARVIV-GGSSEYKINNKVVQLHEYS 118
            :...:           ..|..  |:|.::|..:..|.|.:.|.|. .|::||||:.::|...||.
pombe    66 YRGKILQRDNTDFTDSSNPTT--AYVKLMYELDNGEQREYKRAITPSGATEYKIDEEIVTFSEYC 128

Human   119 EELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQ 183
            ..|:|..||::|||||||||.||:||.::|.|.:.|.|:||.|.|...||||.|.|..||...:.
pombe   129 GSLQKENILVRARNFLVFQGDVETIASQSPLELSKLVEQISGSLEYKSEYDKSKDEQDKAVNLSA 193

Human   184 FNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKE 248
            .::::|:.|.||.::.:::|.||:|||..|::...||:...|:||:|       |.|.::|...|
pombe   194 HSFNKKRGINAELRQYQEQKTEAERYQSQKEKRDSAQLVYLLWKLFH-------LEKSISSNMAE 251

Human   249 IEKDK-------KRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTS 306
            :.:.|       :|.|:...|:::.|::.|.:.|.....::::::::..:..|||:.|...|...
pombe   252 VTRLKADSIQLIERRDENTKEIEKLKEKEGSIRRNLLAFDRKVRKQEKLIASKRPELISIAEKAL 316

Human   307 HKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQ 371
            .....|...::.....:|.|..:...:..||.::.|:..|.:||.:.|:|:.|.:|..|..|:.:
pombe   317 ESKSNLRKIQRKAAEIEKDYSDQASTLQVLENQLTSLSAAEKEFLKDMQEKEQLKGLRLLPEDKE 381

Human   372 VKKYHRLKEEASKRAATLAQELEKFNRDQKA---DQDRL-----DLEERKK--------VETE-- 418
              :|..|:.||.|..:.|..:|:..||:.|.   .:|.|     |||.:.|        ::||
pombe   382 --EYEGLRSEADKLNSNLLFKLQTLNRNIKVTSQSKDSLTSIVGDLESKIKSLHESVSSLDTERA 444

Human   419 ---AKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQV 480
               |||.:|:..:|        ||::        ::|||   .||......|.:  |:|:||...
pombe   445 DLLAKINEKIESLE--------LEKH--------DQQKK---RLTYSELFHKTQ--ELNEELQSC 488

Human   481 MEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAI 545
            ::::.:|..||.||.:..:|.|.:.::||:|| .|.||:||||.||||||:.|:...||||.|||
pombe   489 LQKILEASADRNESKQDAKKREALYALKRIYP-EVKGRIIDLCTPTQKKYESAIAAALGKNFDAI 552

Human   546 IVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLREL-KGAKLVIDVIRYEPPHIKKAL 609
            :|:::...::||.||||||....||.|:|.:...|.::|.|.. |||:|.|||:.:|..: ::.:
pombe   553 VVETQAVAKECIDYIKEQRIGIMTFFPMDTIAASPVNQKFRGTHKGARLAIDVLNFESEY-ERVM 616

Human   610 QYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKL 674
            ..|.||.|:||::..||.:::......|||.|:||:..|:|:|:||:|:.:: |:.||:...|.|
pombe   617 ISAVGNTLICDSMTVARDLSYNKRLNAKTVTLEGTVIHKTGLITGGSSNNRS-AKHWDDHDFDLL 680

Human   675 KEKKERLTEELKEQMKAKRK-------EAELRQVQSQAHGLQMRLKYSQSDLEQTKTR--HLALN 730
            .:.|:||..::.|....|..       ..:|..::|:...|:.:.......:|..|..  |....
pombe   681 TQTKDRLMHQIGEIEYQKSSCVITESDTVKLHSLESEISLLKDKYTVVSRSVEDKKKEIGHYESL 745

Human   731 LQEK----SKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIRE 791
            ::||    |:||.||.||          ::||:    :|:.::.:||:::|..||:.||:.:|..
pombe   746 IKEKQPHLSELEMELRNF----------VKSRD----ELQIQVEKVEEKIFSGFCKRIGISDIHT 796

Human   792 FEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEE 856
            ::|..........:|:|||..||:.|..::.|||.::.:.:.::....:.::||:..|:..::..
pombe   797 YDEIHRTFTQSFTQKQLEFTKQKSLLENRISFEKQRVSDTRLRLERMHKFIEKDQESIDNYEQNR 861

Human   857 QRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEI-----RKKLGGAN--KEMTHLQKEVTA 914
            :.....:....|:|:.|       |.:...:|.:.|:|     .|||.|..  .|:|.|...:|.
pombe   862 EALESEVATAEAELELL-------KEDFASENSKTEKILLAASEKKLVGKRLVSELTKLSGNITL 919

Human   915 IETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSIYAREAL- 978
            :|:::::..|:.|.:|:.||::||.:||.:|::..|..::.|:.| |...|.:....:...|..
pombe   920 LESEIDRYVSEWHAILRKCKLEDIDVPLREGSLTSIPIDDVSNSG-DITMGEEPSEPVINFEKFG 983

Human   979 IEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSD 1043
            :|:||.:|.|:|::..:|    ...:.||:||.|....|.:: :||::|:|:||:|..:..:..:
pombe   984 VEVDYDELDEELRNDGSE----SMASVLQEKLREYSEELDQM-SPNLRAIERLETVETRLAKLDE 1043

Human  1044 EFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSS----AQAFLGPENPE 1104
            ||.||||.||.||:.|..:|::|..:|.|.|..::..||.|||.|:::.:    ..|:|..::.:
pombe  1044 EFAAARKAAKNAKERFNAVKQKRLQKFQAAFSHISEQIDPIYKELTKSPAFPLGGTAYLTLDDLD 1108

Human  1105 EPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGK 1169
            ||||.||.::.:.|.||||.||.|||||||:||||||||||||:|:|||||||||||||.||:.|
pombe  1109 EPYLGGIKFHAMPPMKRFRDMDQLSGGEKTMAALALLFAIHSYQPSPFFVLDEIDAALDQTNVTK 1173

Human  1170 VANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKY 1223
            :||||::.::..||.:|||||.:.::|:|:|:|:|.:|.: ..|:.|:.:|..|
pombe  1174 IANYIRQHASSGFQFVVISLKNQLFSKSEALVGIYRDQQE-NSSRTLSINLEGY 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC1A	NP_006297.2	SMC_N	3..1210	CDD:426784	443/1272 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	284..308		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..369		7/20 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..966		4/18 (22%)
psm1	NP_596049.2	SMC_N	6..1207	CDD:481474	439/1262 (35%)