DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KDM5C and kdm5c

DIOPT Version :9

Sequence 1:	NP_004178.2	Gene:	KDM5C / 8242	HGNCID:	11114	Length:	1560	Species:	Homo sapiens
Sequence 2:	NP_001072719.1	Gene:	kdm5c / 780176	XenbaseID:	XB-GENE-1033025	Length:	1506	Species:	Xenopus tropicalis

Alignment Length:	1542	Identity:	1052/1542 - (68%)
Similarity:	1222/1542 - (79%)	Gaps:	92/1542 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     5 SDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRI 69
            ::||:||.|||||||:|.||:||||||||||||||||||||||||.|||||||||||||.|||||
Frog     6 TEDFVPPAECPVFEPTWEEFKDPLGYIAKIRPIAEKSGICKIRPPVDWQPPFAVEVDNFHFTPRI 70

Human    70 QRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYEAICKDRRW 134
            ||||||||:|||||||||||||||||||||||||||||||||||||:|||.||||||.||::|||
Frog    71 QRLNELEAETRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLNKIVQEEGGYEPICRERRW 135

Human   135 ARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRP-FDNEEKDKEYKPHSIPLR 198
            ||||||:.||.|||:|||||||||||:||:.|||||||:|....|| :|||||||||||||||||
Frog   136 ARVAQRMGYPSGKNLGSLLRSHYERIIYPFHMYQSGANMVDYRERPRYDNEEKDKEYKPHSIPLR 200

Human   199 QSVQPSKFNSYGRRAKRL----------------QPD------PEPTEEDIEKNPELKKLQIYGA 241
            |||||||..|||||||||                ||.      ||||.|||||||||||||||||
Frog   201 QSVQPSKITSYGRRAKRLTQEDPENSDPAAQSSSQPTETSPSWPEPTVEDIEKNPELKKLQIYGA 265

Human   242 GPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEEL-------GGDVKVESTSPKTFLESKEELS 299
            ||||||||||||:|.|||||.:.||||||:|:|||:       .|:|:|         ..|:|.|
Frog   266 GPKMMGLGLMAKNKNLRKKDSDIPECPPTLVIKEEVPVEGRGEPGEVQV---------HVKQERS 321

Human   300 HSPEPCTKMTMRLRRN---HSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEI 361
            .|||||||||||||||   :|| ||::||:||:|||||:||:||||||||||||.|||||||||.
Frog   322 LSPEPCTKMTMRLRRNTITNSN-QFVDSYICRICSRGDDDDRLLLCDGCDDNYHTFCLLPPLPEP 385

Human   362 PKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFW 426
            |||:|.||||||||||||||||||||||||:||||||||||:|||||||||||||||||||||||
Frog   386 PKGIWHCPKCVMAECKRPPEAFGFEQATREFTLQSFGEMADAFKADYFNMPVHMVPTELVEKEFW 450

Human   427 RLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHIN 491
            ||||||||||||:|||||||||||||||:.|.|..|:|||:.|||||||||||||||||||||||
Frog   451 RLVNSIEEDVTVQYGADIHSKEFGSGFPMLDGKTELSPEEKAYATSGWNLNVMPVLEQSVLCHIN 515

Human   492 ADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPEL 556
            ||||||||||||||||||||||||||||||||||||||||||||||||.|||.||:|||||||||
Frog   516 ADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSSAAEQLEDVMKKLTPEL 580

Human   557 FDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTAD 621
            |:|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||
Frog   581 FESQPDLLHQLVTLMNPNTLMAHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTAD 645

Human   622 WLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLE 686
            ||||||:||||||||||||||||||||||||||||:||::||||||||||::|||||||||.|||
Frog   646 WLPAGRKCIEHYRRLRRYCVFSHEELICKMAACPERLDMSLAAAVHKEMFLLVQEERRLRKTLLE 710

Human   687 KGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRY 751
            :|:||||||||||||||||||.|||||||||||||||||.|||||.||.|||:|..|||||||||
Frog   711 QGVTEAEREAFELLPDDERQCQKCKTTCFLSALACYDCPQGLVCLYHIEDLCQCPPSRQYLRYRY 775

Human   752 TLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQQLK 816
            |||||||||||||.||||||||:||||:|:|::...|:.|.||:.||:||.|::|..:|.||.|:
Frog   776 TLDELPAMLHKLKGRAESFDTWSNKVRLAIELDGKTKKELVELKTLEAEAFEKKFVENEHLQLLR 840

Human   817 NCLSEAEACVSRALGLVSGQEAGPHRVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVLEQVE 881
            ..:.|.|:|::.|..::...:|  :|.....::|..|...:.::.::||.:.|:..::.:.|:.|
Frog   841 GSIQEVESCIAEAKKVLGFSQA--NRSHSTVISLEGLIKLVKRIQSVPCVVPQLSQLQCLQEEAE 903

Human   882 AYQAEAREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGT 946
            ..|.||:::|.:|.:|...|:.:|||.:.|.||||..:|::|.:.|..||:.| ||...|.|.||
Frog   904 TLQEEAQKSLLTLSNSTSQLREVLERCQALTVEVPAVRQIERHLRQGEWLERV-RTALSSGRSGT 967

Human   947 LAVMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIREAEN 1011
            |..||.||.....||.||||:||::|||||::||.||||||.:|||||:|||||.|||||:|||:
Frog   968 LQEMRSLLKEAEEVAESPAVEKARSELQELISIALRWEEKAQMCLEARKKHPPAMLEAIIKEAEH 1032

Human  1012 IPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVL 1076
            |||.|||..:|||||.|||||.|||:|||:||||||||||||||||||||||.:|||.|||:||.
Frog  1033 IPVQLPNTLSLKEALCKARAWSADVEEIQSGDHYPCLDDLEGLVAVGRDLPVKMEELHQLEVQVA 1097

Human  1077 TAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRW-MEKELGLYKSDTELLGLSAQDL 1140
            .|||||||||||||||||||||||||||.||..||:.||||| .|||.|||:||.|.||||||||
Frog  1098 AAHSWREKASKTFLKKNSCYTLLEVLCPSADVCSDTGKRSRWKKEKEQGLYRSDIESLGLSAQDL 1162

Human  1141 RDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLAGAGALQCDLC 1205
            ||||.:::||||||||||.|||:||..||           :.....:||||:. .....|:|:||
Frog  1163 RDPGCIVLAFKEGEQKEKAGILRLRAMNS-----------SLERGCVCVCGEP-PDELMLRCELC 1215

Human  1206 QDWFHGRCVSVPRLLSSPRPNPTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPV 1270
            ||.|||.||..|||  |......:.|.|.|||||::|||.||:|||||||:|||:||||||:|||
Frog  1216 QDLFHGLCVPSPRL--SNHRGAHTMPSLIWWEWDSRFLCSLCVRSRRPRLQTILSLLVALQKLPV 1278

Human  1271 RLPEGEALQCLTERAISWQGRARQALASEDVTALLGRLAELRQRLQAEPRPEEPPNYPAAPASDP 1335
            |||||||||||||||:|||.|||:.||:.::::....|||.||::|..             ..||
Frog  1279 RLPEGEALQCLTERAMSWQDRARRVLATPEISSAATALAERRQKMQQH-------------CKDP 1330

Human  1336 --LREGSGKDMPKVQGLLENGDSVTSPEKVAPEEGS-GKRDLELLSSLLPQL-TGPVLELPEATR 1396
              |||.:..:...|.  .||||..|       |.|: ...||:.:::|||:| ...:|||...:|
Frog  1331 QALRETTRNEQNPVP--QENGDCHT-------ENGTCAMPDLDAMAALLPRLEKTAILELSLGSR 1386

Human  1397 APLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLERIRTLLELEKAERHGSRARGRALERRRRR 1461
            |.||:||:|||||||:|:|..|||:||.|.|.|.:||:|||:|:|:.||..:|.:|:..|:|::|
Frog  1387 ALLEDLMLEGDLLEVSLEEEASIWRLLLASQVPCIERLRTLIEIERCERRLARQKGKDPEKRKKR 1451

Human  1462 KVDRGGEGDDP---AREELEPKRVRSSGPEAEEVQEEEELEEETGGE 1505
            :.:| |:|..|   .:|||.|||.||. ..|:|...::|...:.|.|
Frog  1452 RSER-GDGYSPPILPKEELGPKRCRSD-IRAQETLSDKESPRKGGSE 1496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDM5C	NP_004178.2	JmjN	13..54	CDD:128818	36/40 (90%)
		BRIGHT	80..170	CDD:128777	77/89 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..227		25/51 (49%)
		PHD1_KDM5C_5D	326..371	CDD:277077	36/44 (82%)
		JmjC	501..617	CDD:202224	110/115 (96%)
		zf-C5HC2	707..759	CDD:280996	44/51 (86%)
		PLU-1	772..1098	CDD:285609	177/325 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1161..1181		6/19 (32%)
		PHD2_KDM5C_5D	1187..1247	CDD:277081	29/59 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1316..1371		14/57 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1444..1560		24/65 (37%)
kdm5c	NP_001072719.1	JmjN	14..55	CDD:128818	36/40 (90%)
		BRIGHT	81..171	CDD:128777	77/89 (87%)
		PHD_SF	350..395	CDD:304600	36/44 (82%)
		JmjC	525..641	CDD:202224	110/115 (96%)
		zf-C5HC2	731..783	CDD:280996	44/51 (86%)
		PLU-1	796..1119	CDD:285609	177/325 (54%)
		PHD2_KDM5C_5D	1198..1255	CDD:277081	29/59 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	351	1.000	Domainoid score	I7353
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H79498
Inparanoid	1	1.050	2067	1.000	Inparanoid score	I625
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15517at32523
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm55055
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R628
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.190