DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KDM5C and Utx

DIOPT Version :9

Sequence 1:	NP_004178.2	Gene:	KDM5C / 8242	HGNCID:	11114	Length:	1560	Species:	Homo sapiens
Sequence 2:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster

Alignment Length:	830	Identity:	161/830 - (19%)
Similarity:	267/830 - (32%)	Gaps:	258/830 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    38 AEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQG----- 97
            :::..:|.|...  |..|.::|            :|..:.||...|.  .|:.|...:||
  Fly   452 SKRRQLCSIEEA--WNLPISLE------------MNSRQQQTAQMLP--RQVTKQSPVQGPPPPY 500

Human    98 -----SSLKIPNVERRILDLYSLSKIVVEEGGYEAICKDRRWARVAQRLNYPPGKNIGSLLRSHY 157
                 |...||            ||.:.|:|..:        ..|.|..:....:|:.::..|..
  Fly   501 PHSQLSQSPIP------------SKRIKEDGTSQ--------QEVTQNNSQTSAQNLINISESLN 545

Human   158 ERIVYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEP 222
            :|..  ..|.:|..:..|.....||:...|...:..||.|.:..|.:..|:...|...:..|...
  Fly   546 QRNF--NAMPESNKSSEQSVLDTFDDISNDIYKQNESIKLERLSQDALSNNEDSRHDFIGGDNAD 608

Human   223 TEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDK--------TLRKKDKEGPECPPTVVVKEELGG 279
            .....:...:.|:|        |:.:.|:..|:        .:.......|:|||..:.:::|
  Fly   609 ISTTFKIQMDSKQL--------MVAVKLLPIDEPPVHCTILQVNAPPPSPPDCPPQKLTRDQL-- 663

Human   280 DVKVESTSPKTFLESKEELSHSP---EPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLL 341
                ...:|...||:|:. :.||   |.|.|..:.:.|..:....::        .|....|.|:
  Fly   664 ----LPPTPSVHLENKKH-AFSPQLQEFCLKHPIAVVRGLAGVLKLD--------LGLFSTKTLV 715

Human   342 CDGCDDNYHIFCLLPPLPE------IPKGVWRC----PKCVMAECKRPPEAFGFEQATREYTLQS 396
            ....|.:..:...:...|:      ..|.||.|    ....:|:             ..:|...|
  Fly   716 EANPDHSVEVRTQVHQSPDENWDTSQGKRVWACISHRSHTTIAK-------------YAQYQASS 767

Human   397 FGEMADSFKADYFNMPVHMVPTELVEKEF---WRLVNSIEED-------VTVEYGADIHSK--EF 449
            |   .||.|.        ::|.:..:|.|   ..:.:|..:|       |.......|:||  .|
  Fly   768 F---QDSLKL--------ILPQDESDKGFPGSQAMSDSDSKDSVSNSNIVLKRKKHKINSKMLRF 821

Human   450 GSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQ-----SVLCHINADISGMKVPWLYVGMVFS 509
            |:...:||.|: ..|:..|       |..:|...:     ::|.|:...|.||....||:.:..|
  Fly   822 GTNVDLSDEKK-WKPQLTE-------LQKLPAFARVISAANMLSHVGHVILGMNTVQLYMKVPGS 878

Human   510 AFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPN 574
            ....|.|::...|||.........|:.||                   |:....:|.|....|.:
  Fly   879 RTPGHQENNNFCSININIGPGDCEWFAVP-------------------DAYWGGVHNLCEKNNIS 924

Human   575 TLMSHG-------------VPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFC-TADW--- 622
            .|  ||             :||.|..|..|:.|.......|        :.:::.:| ...|
  Fly   925 YL--HGSWWPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVH--------WVQSIGWCNNIAWNVG 979

Human   623 -LPAGRQ---CIEHYR------------------RLRRYCVFSHEELICKMAACPEKLDLNLAAA 665
             |.| ||   .||.|.                  .|.|....|..:|...:..|   |...|...
  Fly   980 PLTA-RQYSLAIERYEWNKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMC---LLQTLKNV 1040

Human   666 VHKEMFIMVQEERRLRKALLEKGITEA-------EREAFELLPDDERQ------CIKCKTTCFLS 717
            :|.:.::   :.:.:......:|..||       |.|.|.:|...|::      |:.|
  Fly  1041 LHIQEYV---KSKGVEIRFNGRGKNEASHYCGQCEVEVFNVLFIKEQEKRHVVHCLSC------- 1095

Human   718 ALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAM-----LHK 762
            ||.......|:|||.                 .|.|.||..:     ||:
  Fly  1096 ALKLSPSLQGIVCLE-----------------EYRLSELQRVYDSFTLHR 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDM5C	NP_004178.2	JmjN	13..54	CDD:128818	3/15 (20%)
		BRIGHT	80..170	CDD:128777	18/99 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..227		5/29 (17%)
		PHD1_KDM5C_5D	326..371	CDD:277077	9/54 (17%)
		JmjC	501..617	CDD:202224	25/128 (20%)
		zf-C5HC2	707..759	CDD:280996	12/51 (24%)
		PLU-1	772..1098	CDD:285609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1161..1181
		PHD2_KDM5C_5D	1187..1247	CDD:277081
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1316..1371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1444..1560
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809
		TPR_11	156..216	CDD:290150
		TPR repeat	186..216	CDD:276809
		TPR repeat	228..255	CDD:276809
		TPR_11	264..337	CDD:290150
		TPR repeat	265..300	CDD:276809
		TPR repeat	307..334	CDD:276809
		TPR_11	339..402	CDD:290150
		TPR repeat	339..369	CDD:276809
		TPR_1	340..373	CDD:278916
		TPR repeat	374..402	CDD:276809
		JmjC	870..978	CDD:202224	27/136 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900