DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KDM5C and Kdm5

DIOPT Version :10

Sequence 1:NP_004178.2 Gene:KDM5C / 8242 HGNCID:11114 Length:1560 Species:Homo sapiens
Sequence 2:NP_523486.1 Gene:Kdm5 / 33837 FlyBaseID:FBgn0031759 Length:1838 Species:Drosophila melanogaster


Alignment Length:1660 Identity:695/1660 - (41%)
Similarity:949/1660 - (57%) Gaps:257/1660 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     8 FLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRL 72
            |..|||||||.|:..||::||.||:|||.||||.||.||.|||.|.|||||:||..||.||:|||
  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219

Human    73 NELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYEAICKDRRWARV 137
            |||||:||||||:|||||||||:||||||||.|||:.||||:|.:||.||||.|...|||:||:|
  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284

Human   138 AQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDK-------EYKPHSI 195
            |.|:.||..|::|:.|::|||||::|:|:|.||..|....|.........|       :||.|.|
  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEI 349

Human   196 PLRQSV-QPSKFNSYGRRAKR------------LQPDPEP---------TEEDIEKNPELKKLQI 238
            |.||.: .|::.|:  ||:||            :.|..:|         |:|:. |...|.....
  Fly   350 PTRQQIAPPNETNT--RRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEF-KRDLLSSFNA 411

Human   239 YGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPE 303
            ..:|...:..|..|  .|.....|:|.| ||.::|                             :
  Fly   412 VNSGGSPLATGTTA--NTRGASQKKGGE-PPALIV-----------------------------D 444

Human   304 PCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRC 368
            |..|                 |:|.:|:|||.::.:||||||||:||.|||||||..||||.|.|
  Fly   445 PLMK-----------------YICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLC 492

Human   369 PKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIE 433
            |:||:.|..:|.||||||||.||||||.||:|||.||.:||..|||:||||:||:||||:|:||:
  Fly   493 PRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSID 557

Human   434 EDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMK 498
            ||||||||||:|:.:.||||| :.|..:|.|.::|||.|.||||.:|:||.|:|.|||||||||.
  Fly   558 EDVTVEYGADLHTMDHGSGFP-TKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMN 621

Human   499 VPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDL 563
            .||:||||.|:|||||.|||||||||||||||||||||||...||..||.||:..||||.|||||
  Fly   622 APWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDL 686

Human   564 LHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQ 628
            ||||||:||||.||::.|||.||:|.|||||||||||||:||||||||||||||..||||..||:
  Fly   687 LHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRE 751

Human   629 CIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAE 693
            |:.||..|||:|||||:||:||||..|.||...:|.|.:.:|..||..|::|||:|||.|:|.||
  Fly   752 CVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAE 816

Human   694 REAFELLPDDERQCIKCKTTCFLSALACYDCPDGL-VCLSHINDLCKCSSSRQYLRYRYTLDELP 757
            |.||||:.||||.|.:|.|||||||:|| :|.|.| |||.|...||.|:..:..|.|||||||:|
  Fly   817 RRAFELVNDDERHCQECNTTCFLSAVAC-ECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMP 880

Human   758 AMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEA 822
            .||.||||:|.||:.|.::.|..::.......:|:||:.|..||..::||:|.|:.:|.....||
  Fly   881 LMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAAVEA 945

Human   823 EACVS--RALGLVSGQEAGPH--RVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVL----EQ 879
            |.||:  :.||:...:....|  ..|..::|:.||..|:.:::||.|.:.:...|:.:|    :.
  Fly   946 EKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGASVRELLVLGKQF 1010

Human   880 VEAYQAEAREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRT--LAPSA 942
            ||..:::.:.:|.||..|.  |::|:..|..|.:|:.:...||::::|.:|   .||:  |..::
  Fly  1011 VERSESQLQLSLESLEESE--LETLINEGSSLRIELQQLDLLQKRLKQCKW---YKRSQGLRETS 1070

Human   943 RRGTLAVMRGLL-VAGASVAPS-PAVDKAQAELQELLTIAERWE-EKAHLCLEARQKHPPATLEA 1004
            .:.|...::.|| :|.|.:.|: |.|||...:||::....|.|| :.|.......|:|....:|.
  Fly  1071 SKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIEQ 1135

Human  1005 IIREAENIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELR 1069
            .::.|.:|...:|:...||:||.|||.|:..|:::|..:|......||.::..|.::|:.||||.
  Fly  1136 FLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLEELS 1200

Human  1070 QLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADA-GSDSTKRSRWME---KELGLYKSDT 1130
            :::..:.:||.|::..:..||||.:.|||||||.|.:|| ..||..:.|:.:   ||        
  Fly  1201 RMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSDLKPRFQDDFLKE-------- 1257

Human  1131 ELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLA 1195
                      ::|..::.:||..|::|...:.:|||.|..| :|:..        ..|:|.....
  Fly  1258 ----------KNPAEIVASFKHAEEQELLDMRELRRQNMNK-NPMRD--------MFCLCKSEFR 1303

Human  1196 GAGALQCDLCQDWFHGRCVSVPRLLSSPRPN---------PTSSPLLAWWEWDTKFLCPLCMRSR 1251
            .. ...|.||:||||..||..|   |:...|         .|:.|         |:|||.|:||:
  Fly  1304 NL-MFNCQLCRDWFHEDCVPPP---SATNQNGIVNGGSGPGTNRP---------KWLCPSCVRSK 1355

Human  1252 RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALL-GRLAELRQRL 1315
            ||||||||.|||.||:||:||||.|||:||.|||::||.|||:||:|.||:|.. ..:|:.:|:.
  Fly  1356 RPRLETILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKR 1420

Human  1316 QAE--------PRPEEPPNYPAAPASDPLREGSG-----------KDMPKVQGLLENGDSVTSPE 1361
            ::|        ..|.:|..     .....:|.||           :|..:::.:.:|..:.....
  Fly  1421 RSEGGAGVGNISSPRKPRR-----RGSLTKEASGSTESDADDDDDEDECRLRIVEDNFSNDEDEP 1480

Human  1362 KVAPEEGSGKRD-LELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQA 1425
            :.||...:...| |:|||              ::....|.:||||||||||:|||...:|::|:.
  Fly  1481 RTAPATSTVNSDLLKLLS--------------DSEIENLLDLMMEGDLLEVSLDETQELWRILET 1531

Human  1426 GQPPDLERIRTLLELEKAER--------------------------------------HGSRARG 1452
             .||      |||:.|..||                                      :...|.|
  Fly  1532 -MPP------TLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQNSPNSNSNSGGATG 1589

Human  1453 RAL---ERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTT 1514
            .|.   ..::||..|.||....|.:::..||:.......|...::.:       .:..||...|.
  Fly  1590 SASNSGRNKKRRSNDTGGNSAVPRKKQSTPKQTPGKKGSAAAARKSD-------AKASPAASTTP 1647

Human  1515 GSPSTQENQ--NG--LEPAEGTTSGPSAPFSTLTP 1545
            |:.:..||:  ||  ...:.|:..|.||   |.||
  Fly  1648 GADADAENKQANGGNTNSSTGSGGGNSA---TTTP 1679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KDM5CNP_004178.2 JmjN 13..54 CDD:128818 27/40 (68%)
ARID_KDM5C_5D 79..170 CDD:350639 59/90 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 197..227 12/51 (24%)
PHD1_KDM5C_5D 326..371 CDD:277077 29/44 (66%)
JmjC 501..617 CDD:396791 92/115 (80%)
zf-C5HC2 707..759 CDD:460750 30/52 (58%)
PLU-1 772..1100 CDD:462475 100/340 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1181 6/19 (32%)
PHD2_KDM5C_5D 1187..1247 CDD:277081 20/68 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1316..1371 10/73 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1444..1560 29/147 (20%)
Kdm5NP_523486.1 JmjN 160..201 CDD:128818 27/40 (68%)
ARID_JARID 226..312 CDD:350628 57/85 (67%)
PHD1_Lid_like 450..495 CDD:277078 29/44 (66%)
JmjC 624..740 CDD:396791 92/115 (80%)
zf-C5HC2 830..882 CDD:460750 30/52 (58%)
PLU-1 896..1231 CDD:462475 100/339 (29%)
PHD2_KDM5A 1295..1351 CDD:277079 20/68 (29%)
PHD3_KDM5A_like 1755..1805 CDD:277083
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.