DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KDM5C and lid

DIOPT Version :9

Sequence 1:	NP_004178.2	Gene:	KDM5C / 8242	HGNCID:	11114	Length:	1560	Species:	Homo sapiens
Sequence 2:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster

Alignment Length:	1660	Identity:	695/1660 - (41%)
Similarity:	949/1660 - (57%)	Gaps:	257/1660 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     8 FLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRL 72
            |..|||||||.|:..||::||.||:|||.||||.||.||.|||.|.|||||:||..||.||:|||
  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219

Human    73 NELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYEAICKDRRWARV 137
            |||||:||||||:|||||||||:||||||||.|||:.||||:|.:||.||||.|...|||:||:|
  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284

Human   138 AQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDK-------EYKPHSI 195
            |.|:.||..|::|:.|::|||||::|:|:|.||..|....|.........|       :||.|.|
  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEI 349

Human   196 PLRQSV-QPSKFNSYGRRAKR------------LQPDPEP---------TEEDIEKNPELKKLQI 238
            |.||.: .|::.|:  ||:||            :.|..:|         |:|:. |...|.....
  Fly   350 PTRQQIAPPNETNT--RRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEF-KRDLLSSFNA 411

Human   239 YGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPE 303
            ..:|...:..|..|  .|.....|:|.| ||.::|                             :
  Fly   412 VNSGGSPLATGTTA--NTRGASQKKGGE-PPALIV-----------------------------D 444

Human   304 PCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRC 368
            |..|                 |:|.:|:|||.::.:||||||||:||.|||||||..||||.|.|
  Fly   445 PLMK-----------------YICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLC 492

Human   369 PKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIE 433
            |:||:.|..:|.||||||||.||||||.||:|||.||.:||..|||:||||:||:||||:|:||:
  Fly   493 PRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSID 557

Human   434 EDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMK 498
            ||||||||||:|:.:.||||| :.|..:|.|.::|||.|.||||.:|:||.|:|.|||||||||.
  Fly   558 EDVTVEYGADLHTMDHGSGFP-TKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMN 621

Human   499 VPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDL 563
            .||:||||.|:|||||.|||||||||||||||||||||||...||..||.||:..||||.|||||
  Fly   622 APWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDL 686

Human   564 LHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQ 628
            ||||||:||||.||::.|||.||:|.|||||||||||||:||||||||||||||..||||..||:
  Fly   687 LHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRE 751

Human   629 CIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAE 693
            |:.||..|||:|||||:||:||||..|.||...:|.|.:.:|..||..|::|||:|||.|:|.||
  Fly   752 CVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAE 816

Human   694 REAFELLPDDERQCIKCKTTCFLSALACYDCPDGL-VCLSHINDLCKCSSSRQYLRYRYTLDELP 757
            |.||||:.||||.|.:|.|||||||:|| :|.|.| |||.|...||.|:..:..|.|||||||:|
  Fly   817 RRAFELVNDDERHCQECNTTCFLSAVAC-ECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMP 880

Human   758 AMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQQLKNCLSEA 822
            .||.||||:|.||:.|.::.|..::.......:|:||:.|..||..::||:|.|:.:|.....||
  Fly   881 LMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAAVEA 945

Human   823 EACVS--RALGLVSGQEAGPH--RVAGLQMTLTELRAFLDQMNNLPCAMHQIGDVKGVL----EQ 879
            |.||:  :.||:...:....|  ..|..::|:.||..|:.:::||.|.:.:...|:.:|    :.
  Fly   946 EKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGASVRELLVLGKQF 1010

Human   880 VEAYQAEAREALASLPSSPGLLQSLLERGRQLGVEVPEAQQLQRQVEQARWLDEVKRT--LAPSA 942
            ||..:::.:.:|.||..|.  |::|:..|..|.:|:.:...||::::|.:|   .||:  |..::
  Fly  1011 VERSESQLQLSLESLEESE--LETLINEGSSLRIELQQLDLLQKRLKQCKW---YKRSQGLRETS 1070

Human   943 RRGTLAVMRGLL-VAGASVAPS-PAVDKAQAELQELLTIAERWE-EKAHLCLEARQKHPPATLEA 1004
            .:.|...::.|| :|.|.:.|: |.|||...:||::....|.|| :.|.......|:|....:|.
  Fly  1071 SKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIEQ 1135

Human  1005 IIREAENIPVHLPNIQALKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELR 1069
            .::.|.:|...:|:...||:||.|||.|:..|:::|..:|......||.::..|.::|:.||||.
  Fly  1136 FLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLEELS 1200

Human  1070 QLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADA-GSDSTKRSRWME---KELGLYKSDT 1130
            :::..:.:||.|::..:..||||.:.|||||||.|.:|| ..||..:.|:.:   ||
  Fly  1201 RMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSDLKPRFQDDFLKE-------- 1257

Human  1131 ELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASSSTASSTTSICVCGQVLA 1195
                      ::|..::.:||..|::|...:.:|||.|..| :|:..        ..|:|.....
  Fly  1258 ----------KNPAEIVASFKHAEEQELLDMRELRRQNMNK-NPMRD--------MFCLCKSEFR 1303

Human  1196 GAGALQCDLCQDWFHGRCVSVPRLLSSPRPN---------PTSSPLLAWWEWDTKFLCPLCMRSR 1251
            .. ...|.||:||||..||..|   |:...|         .|:.|         |:|||.|:||:
  Fly  1304 NL-MFNCQLCRDWFHEDCVPPP---SATNQNGIVNGGSGPGTNRP---------KWLCPSCVRSK 1355

Human  1252 RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQALASEDVTALL-GRLAELRQRL 1315
            ||||||||.|||.||:||:||||.|||:||.|||::||.|||:||:|.||:|.. ..:|:.:|:.
  Fly  1356 RPRLETILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKR 1420

Human  1316 QAE--------PRPEEPPNYPAAPASDPLREGSG-----------KDMPKVQGLLENGDSVTSPE 1361
            ::|        ..|.:|..     .....:|.||           :|..:::.:.:|..:.....
  Fly  1421 RSEGGAGVGNISSPRKPRR-----RGSLTKEASGSTESDADDDDDEDECRLRIVEDNFSNDEDEP 1480

Human  1362 KVAPEEGSGKRD-LELLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQA 1425
            :.||...:...| |:|||              ::....|.:||||||||||:|||...:|::|:.
  Fly  1481 RTAPATSTVNSDLLKLLS--------------DSEIENLLDLMMEGDLLEVSLDETQELWRILET 1531

Human  1426 GQPPDLERIRTLLELEKAER--------------------------------------HGSRARG 1452
             .||      |||:.|..||                                      :...|.|
  Fly  1532 -MPP------TLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQNSPNSNSNSGGATG 1589

Human  1453 RAL---ERRRRRKVDRGGEGDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEGPPAPIPTT 1514
            .|.   ..::||..|.||....|.:::..||:.......|...::.:       .:..||...|.
  Fly  1590 SASNSGRNKKRRSNDTGGNSAVPRKKQSTPKQTPGKKGSAAAARKSD-------AKASPAASTTP 1647

Human  1515 GSPSTQENQ--NG--LEPAEGTTSGPSAPFSTLTP 1545
            |:.:..||:  ||  ...:.|:..|.||   |.||
  Fly  1648 GADADAENKQANGGNTNSSTGSGGGNSA---TTTP 1679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDM5C	NP_004178.2	JmjN	13..54	CDD:128818	27/40 (68%)
		BRIGHT	80..170	CDD:128777	58/89 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..227		12/51 (24%)
		PHD1_KDM5C_5D	326..371	CDD:277077	29/44 (66%)
		JmjC	501..617	CDD:202224	92/115 (80%)
		zf-C5HC2	707..759	CDD:280996	30/52 (58%)
		PLU-1	772..1098	CDD:285609	98/338 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1161..1181		6/19 (32%)
		PHD2_KDM5C_5D	1187..1247	CDD:277081	20/68 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1316..1371		10/73 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1444..1560		29/147 (20%)
lid	NP_001245908.1	JmjN	160..201	CDD:128818	27/40 (68%)
		ARID	227..312	CDD:198082	56/84 (67%)
		PHD1_Lid_like	450..495	CDD:277078	29/44 (66%)
		JmjC	624..740	CDD:202224	92/115 (80%)
		zf-C5HC2	830..882	CDD:280996	30/52 (58%)
		PLU-1	896..1229	CDD:285609	98/337 (29%)
		PHD2_KDM5A	1295..1351	CDD:277079	20/68 (29%)
		PHD3_KDM5A_like	1755..1805	CDD:277083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151681
Domainoid	1	1.000	221	1.000	Domainoid score	I2615
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1252	1.000	Inparanoid score	I176
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53001
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm40656
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R628
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800