DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KDM5C and jmj2

DIOPT Version :9

Sequence 1:	NP_004178.2	Gene:	KDM5C / 8242	HGNCID:	11114	Length:	1560	Species:	Homo sapiens
Sequence 2:	NP_593492.1	Gene:	jmj2 / 2543275	PomBaseID:	SPAC1002.05c	Length:	715	Species:	Schizosaccharomyces pombe

Alignment Length:	784	Identity:	240/784 - (30%)
Similarity:	365/784 - (46%)	Gaps:	163/784 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    12 PECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELE 76
            |..|||.|...||:|.:|||.||.||.||.||.||.|||.|.||..::::.|.|..|.|.|:.::
pombe    58 PVAPVFYPDKEEFQDSIGYINKIAPIGEKYGIIKIVPPAGWNPPMQLDMNKFSFRTRRQDLHMMD 122

Human    77 AQTRVKLNYLDQIAKFWEIQGSSLKIPN---VERRILDLYSLSKIVVEEGGY-EAICKDRRWARV 137
            .:.|..::|.:::.:|:...|  :::|.   :....:|||||.:.:...... |...|...|.|:
pombe   123 LRFREIVSYDERVYRFFCNLG--MELPESFFISNTSIDLYSLMRCIDSHASLSEKELKVHVWKRI 185

Human   138 AQRLNYP----PGKNIGSLLRSHYERIVYPYE----MYQSGANLVQCNTRPFDNE------EKDK 188
            .:.|:.|    ..|....|    |.|.::|:|    .||:..:  ||    |:.:      .||:
pombe   186 LRELSIPFTNASLKEASDL----YLRYIFPFEDFVRKYQTSED--QC----FETDLFPKFFTKDE 240

Human   189 EYKPHS-IPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMA 252
                || |.::......:||            ||..|                      .:|::.
pombe   241 ----HSNISIKDQKTSKQFN------------PETNE----------------------SVGILQ 267

Human   253 KDKTLRKKDKEGPECPPTVVVKEELGGDVKVESTSPKTFLESKEELSHSPEPCTKMTMRLRRNHS 317
            ..::.|.:.           :|::.         .|.....|.:..||:.          :|..|
pombe   268 NQESKRNEQ-----------IKQQY---------MPADNFGSNDNHSHNK----------KRRLS 302

Human   318 NAQFIESYVCRMCSRGDEDDKLLLC---DGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRP 379
            :.....:::|..|      .|.:.|   |.|.:.|                  |.||::     .
pombe   303 SLSTNNNHLCDNC------HKPVNCEVEDTCKEAY------------------CTKCII-----N 338

Human   380 PEAFGFEQATREYTLQSFGEMADSFKADYFN-MPVHMVPTELVEKEFWRLVNSIEEDVTVEYGAD 443
            |..||||.. ..|||.:|.:..|:||.:||: .....:..::||||:|:||......:.||||||
pombe   339 PYEFGFETG-NYYTLSNFEKYCDNFKKNYFSKFKDSEITEDIVEKEYWKLVKDNNTSLEVEYGAD 402

Human   444 IHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVF 508
            :.:.:.||.|| |.:|..:.|    |:...|||||:.....|:|.:|:..:||:..|||||||.|
pombe   403 LSTLDQGSAFP-SLAKNPVNP----YSKDTWNLNVIASTNGSLLSYIDNPVSGITCPWLYVGMCF 462

Human   509 SAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNP 573
            |.||||:||:::||:||.|:|:.|.|||:|...||..|.....:.|:|...|.|||:||.|::||
pombe   463 STFCWHVEDNYTYSVNYQHYGDTKLWYGIPGDQAERFERAALDIAPDLVKKQKDLLYQLATMINP 527

Human   574 NTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQC--IEHYRRL 636
            :.|...||.|...:|...|||||||:::|:|.|.|:|..|||||...|||..|...  :..|:.|
pombe   528 DELQKRGVDVYFIDQGPNEFVITFPKSFHAGINHGFNINEAVNFAPKDWLLNGFSLNGVLKYQSL 592

Human   637 RRYCVFSHEELICKMAACPEKLDLNLA-------AAVHKEM--FIMVQEERRLRKALLEKGITEA 692
            .:..|.||:.|:..:|..|.. :::::       .||.:|:  .||::....|::.|..
pombe   593 LKPPVLSHDMLVYNLATNPAS-EISVSELRPWVHEAVKRELGIRIMIRGRYDLKEILYR------ 650

Human   693 EREAFELLPDDER-QCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDEL 756
                 ||:.|.|. ||..||...:.|.:|| .|....||..||..||||..|.:.||.:...:||
pombe   651 -----ELMEDAENWQCQHCKAFSYFSQVAC-SCKSITVCPLHIEYLCKCDLSNKTLRLKVDDNEL 709

Human   757 PAML 760
            ..:|
pombe   710 QKLL 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDM5C	NP_004178.2	JmjN	13..54	CDD:128818	24/40 (60%)
		BRIGHT	80..170	CDD:128777	24/101 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..227		5/29 (17%)
		PHD1_KDM5C_5D	326..371	CDD:277077	8/47 (17%)
		JmjC	501..617	CDD:202224	59/115 (51%)
		zf-C5HC2	707..759	CDD:280996	20/51 (39%)
		PLU-1	772..1098	CDD:285609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1161..1181
		PHD2_KDM5C_5D	1187..1247	CDD:277081
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1316..1371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1444..1560
jmj2	NP_593492.1	JmjN	59..100	CDD:128818	24/40 (60%)
		BRIGHT	126..218	CDD:128777	22/97 (23%)
		JmjC	455..571	CDD:202224	59/115 (51%)
		zf-C5HC2	661..712	CDD:280996	20/51 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	156	1.000	Domainoid score	I1175
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm53370
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R628
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.840