DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAPN1 and CalpC

DIOPT Version :9

Sequence 1:	NP_001185797.1	Gene:	CAPN1 / 823	HGNCID:	1476	Length:	714	Species:	Homo sapiens
Sequence 2:	NP_573118.2	Gene:	CalpC / 32597	FlyBaseID:	FBgn0260450	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	722	Identity:	212/722 - (29%)
Similarity:	343/722 - (47%)	Gaps:	96/722 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    38 LGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSN-------- 94
            :...||::...|.....|:.|..||.|..|:.|....|     :..:|||..:|..:
  Fly     1 MASKYERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPP-----FTFQWKRIMDLADSGSGAVAAN 60

Human    95 ----PQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQ 155
                |.|:.:.| ..|:..|.:||.||::.:..|:....|.:||||..|:..:.: |:|.|:||.
  Fly    61 SSAAPVFLNESA-EFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWW 123

Human   156 FGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGG 220
            .||||:|:|||.||..:|:|.|:.....|.||:||||||.||::||||||..|:.|:|..|..||
  Fly   124 CGEWVEVLVDDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGG 188

Human   221 VTEWYELRKAP--SDLY--QIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQ 281
            |     :|:.|  ||..  |.:.:.|....::.|..|.|:.:..:.:. :::..|...:
  Fly   189 V-----VRQMPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLA-ERMPNGILVN------ 241

Human   282 VNYR-----------GQVVSLIRMRN-----PWGE-VEWTGAWSDSSSEWNNVDPYERDQLRVKM 329
            ||||           |..|.|:.:::     |:|| ..:.|.||..|..|..|...||.:|..::
  Fly   242 VNYRLSSLDKVKTLMGDSVQLVCLKDTFSSKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQL 306

Human   330 EDGEFWMSFRDFMREFTRLEICNLTPDA------LKSRTIRKWNTTLYEGTWRRGSTAGGCRNYP 388
            ..||||:||.||:..|:.:|:..|..:.      ||||.:. |...:::|.|:||.|||||||:
  Fly   307 GPGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLH-WKMKMHQGQWKRGVTAGGCRNH- 369

Human   389 ATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELV 453
            .:|.:|||..|.:.:..|            .|:||.| |...|.:      .|||.:|....|.:
  Fly   370 ESFHINPQLLISVQDEQD------------LVIALNQ-HTAVEPK------VIGFTMYTWDGEYM 415

Human   454 GQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKS 518
            ....  |::|||..:.|...|: :.|.|.||....|..|.||::|:|:||.:|..|.:|.....|
  Fly   416 LSEC--LQKDFFKNHVSYLNSD-YGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGS 477

Human   519 AGTVELDDQIQANLPDEQVLSEEEIDE----------NFKALFRQLAGEDMEISVKELRTILNRI 573
            .....|:.|....|.....|...:.:.          .::.::.|||.|:..|:..||..:|...
  Fly   478 FRLSCLETQTMILLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCFELHELLEAC 542

Human   574 ISKHKDLRTKG-FSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSA 637
            :...   ..|| .:::.||.::.|.||.|:|::...:|......::::..:|:.:..:|:|.:.|
  Fly   543 LPND---YIKGCANIDICRQVIALQDRSGSGRITFQQFKTFMVNLKSWQGVFKMYTKEKAGILRA 604

Human   638 YEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTF 702
            ..:|.|:...||:|:..:...:|.||...|..:...:||..::.|.|.|..|...:.....|:..
  Fly   605 ERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLTTAFNQFHLKNYGQVNVIEV 669

Human   703 DLFKWLQ 709
            .|..|::
  Fly   670 HLHDWIK 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAPN1	NP_001185797.1	Peptidase_C2	56..352	CDD:306994	108/328 (33%)
		Domain III	355..526		56/176 (32%)
		Calpain_III	364..524	CDD:238132	51/159 (32%)
		Linker	527..542		3/14 (21%)
		Domain IV	543..713		40/178 (22%)
		EFh_PEF_CAPN1	546..714	CDD:320073	40/165 (24%)
		EF-hand motif	546..574	CDD:320073	8/27 (30%)
		EF-hand motif	589..618	CDD:320073	8/28 (29%)
		EF-hand motif	619..649	CDD:320073	6/29 (21%)
		EF-hand motif	655..683	CDD:320073	6/27 (22%)
		EF-hand motif	685..714	CDD:320073	5/25 (20%)
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	110/340 (32%)
		Calpain_III	346..483	CDD:238132	51/160 (32%)
		FRQ1	<567..648	CDD:227455	18/80 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920