DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SYN3 and Syn

DIOPT Version :10

Sequence 1:NP_003481.3 Gene:SYN3 / 8224 HGNCID:11496 Length:580 Species:Homo sapiens
Sequence 2:NP_731459.2 Gene:Syn / 41247 FlyBaseID:FBgn0004575 Length:1041 Species:Drosophila melanogaster


Alignment Length:645 Identity:237/645 - (36%)
Similarity:330/645 - (51%) Gaps:127/645 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     1 MNFLRRRLSDSSFMANL----PNGYMTDLQRP--DSSTSSPASPAMERRHPQPLAASFSSPGSSL 59
            :|||:||.|.....:.:    ||. :....||  |..|..|.:.......|.|  |.....|::.
  Fly    14 VNFLKRRFSSGDLSSEVDDVDPNS-LPPAARPIQDQPTKPPVAGGPPNMPPPP--APGQPAGAAP 75

Human    60 FSSLSSAMKQAPQATSGLMEPPGPSTP---------IVQRPR----------------------- 92
            ..|||....:.| ||:....|.|.|.|         ::||.:                       
  Fly    76 ELSLSFGAGKTP-ATAAPAPPRGVSAPTSPAKSRESLLQRVQSLTGAARDQGASILGAAVQSATQ 139

Human    93 -----------ILLVIDDAHTDWSKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVV 146
                       .|||:||.:|||||||.|::::|:.:||||||||.::.:.:....|.:|.|...
  Fly   140 RAPAFSKDKYFTLLVLDDQNTDWSKYFRGRRLHGDFDIRVEQAEFRDITVVSSADTGPVVTMAAY 204

Human   147 RNGTKVVSRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQL 211
            |:||: |:|||:|||:|:||.....:  .||||.::||:|||:|::|||:|:|.|..||||||.|
  Fly   205 RSGTR-VARSFRPDFVLIRQPPRDGS--SDYRSTILGLKYGGVPSINSLHSIYQFQDKPWVFSHL 266

Human   212 IKIFHSLGPEKFPLVEQTFFPNHKPMVTAPHFPVVVKLGHAHAGMGKIKVENQLDFQDITSVVAM 276
            :::...||.:.|||:|||||||.:.:.....||.|:|.||.|.|:...::|||...||...:|:.
  Fly   267 LQLQRRLGRDGFPLIEQTFFPNPRDLFQFTKFPSVLKAGHCHGGVATARLENQSALQDAAGLVSG 331

Human   277 A----KTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVD 337
            |    ..|.|.|.:||:|:.:.|||||:||||:||.||:||||.|.|||||||:.:||:|:.|||
  Fly   332 AGNDSHCYCTIEPYIDAKFSVHIQKIGNNYKAFMRKSITGNWKTNQGSAMLEQITLTEKYKSWVD 396

Human   338 SCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDRQLMADLVVSKMSQL--PMPG 400
            ..||:|||:::|.:..|.:||||:|||...||:..|||:..||||:.:||||..:|..:  |...
  Fly   397 EISELFGGMEVCGLSVVVAKDGREYIISACDSTFALIGDTQEEDRRQIADLVSGRMQNVCRPSMA 461

Human   401 GTAPSPLRPWAPQIKSAKSPGQAQLGPQLGQPQ-PRPPPQGGPRQAQSPQPQRSGSPSQQRLSPQ 464
            .|.|..|...:.....|:||....:.|....|. |||.|.|||    .|.|:|:           
  Fly   462 QTGPGKLPSRSSVSSRAESPTDEGVAPTPPLPAGPRPAPMGGP----PPIPERT----------- 511

Human   465 GQQPLSPQSGSPQQQRSPGSPQLSRASSGSS----PNQASKPGATLASQPRPPVQG--RSTSQQG 523
                 ||..||           :.|.||.||    |.:.|..|        |...|  |..||  
  Fly   512 -----SPAVGS-----------IGRLSSRSSISEVPEEPSSSG--------PSTVGGVRRDSQ-- 550

Human   524 EESKKPAPPHPHLNKSQSLTNSLSTSDTSQRGTPSED---EAKAETIRNLRKSFASLFSD 580
                          .|||.|.|.|.|...||...:::   |...:|::||||:||.:|.|
  Fly   551 --------------TSQSSTISSSVSRAGQRPPQTQNSVVEDAEDTMKNLRKTFAGIFGD 596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SYN3NP_003481.3 Synapsin_N 1..29 CDD:463155 10/33 (30%)
A 1..28 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 19..56 9/38 (24%)
B, linker 28..90 18/72 (25%)
C, actin-binding and synaptic-vesicle binding 91..399 154/347 (44%)
Synapsin 92..191 CDD:460438 47/132 (36%)
CPSase_L_D2 193..395 CDD:473076 105/205 (51%)
PRK07764 <394..536 CDD:236090 36/150 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 395..567 46/183 (25%)
J, Pro-rich linker 400..531 35/137 (26%)
E 532..580 18/50 (36%)
SynNP_731459.2 Synapsin 150..246 CDD:460438 47/98 (48%)
CPSase_L_D2 248..452 CDD:473076 104/203 (51%)
PHA03307 425..>700 CDD:223039 69/227 (30%)

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