Protein Alignment LZTR1 and KEL2

DIOPT Version :10

• Sequence 1: NP_006758.2
• Gene: LZTR1 / 8216
• HGNCID: 6742
• Length: 840
• Species: Homo sapiens
• Sequence 2: NP_011754.3
• Gene: KEL2 / 853153
• SGDID: S000003470
• Length: 882
• Species: Saccharomyces cerevisiae
• Alignment Length: 865
• Identity: 166/865 - (19%)
• Similarity: 334/865 - (38%)
• Gaps: 195/865 - (22%)

Human    54 WRRLP-PCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRA-------FT 110
            |.|:. ....|...|.|...:|...:.|:|.||.:.:::..|:         |..|       ||
Yeast    73 WNRVKLKNSPFPRYRHSSSFIVTNDNRIFVTGGLHDQSVYGDV---------WQIAANADGTSFT 128

Human   111 T-------GTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIE 168
            :       .||| ||..|::.:.|::..||||.|..:..|..|  .:||:.:...:.:||..:..
Yeast   129 SKRIDIDQNTPP-PRVGHASTICGNAYVVFGGDTHKLNKNGLL--DDDLYLFNINSYKWTIPQPI 190

Human   169 GRLPVARSAHGATVYSD-----KLWIFAGYDGNARLNDMWTIGLQD--RELTCWEEVAQSGEIPP 226
            ||.|:.|..|..::.:.     ||::|.|.......||:....|..  |..:.||.:...|::||
Yeast   191 GRRPLGRYGHKISIIASNPMQTKLYLFGGQVDETYFNDLVVFDLSSFRRPNSHWEFLEPVGDLPP 255

Human   227 SCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVA 291
            ...|..:....:|::||.|::...|:|:.::::.....|:::.|    .|..|||.:.  |..|.
Yeast   256 PLTNHTMVAYDNKLWVFGGETPKTISNDTYRYDPAQSEWSKVKT----TGEKPPPIQE--HASVV 314

Human   292 FDRHLYVFGGA-ADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASEEVPTLTYEER 355
            :...:.|.||. ..|...|:::..::....|..:....:.      :|:.  .|....||...|:
Yeast   315 YKHLMCVLGGKDTHNAYSNDVYFLNLLSLKWYKLPRMKEG------IPQE--RSGHSLTLMKNEK 371

Human   356 ---VGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMY 417
               :|..|:      |:.:.:........::...|.|.:... :|....:..|.:..::.:||.:
Yeast   372 LLIMGGDKT------DYASPNIHDLQTSETDQGEGTLLYTLD-LSSLNELCPGIMCESLHAGESF 429

Human   418 RFQFS---CYPKCTLHEDY-------GRLWESR--QFCDVEFVLGEKEECVQGHVAIVTARSRWL 470
            ....|   ...|.|..|:.       .||.:|:  .:.|::...|.....:.         .:..
Yeast   430 SNSLSGGFTPSKSTESENQEIINILTPRLPDSKVLSYNDIDEGAGSYSSALD---------DKAF 485

Human   471 RRKITQARERLAQKLEQEAAPVPREAPGVAAGGAR---PPLLHVAIREAE--------------- 517
            .|| :...|:..|..:.::: :.:|:||.....::   |.|..:.:...|
Yeast   486 ERK-SDREEKKPQSSKVDSS-INKESPGTGIKVSKKNFPVLRGLTVDSEEYGSSSYKDTSCQKGI 548

Human   518 -ARPFEVLMQFLYTDKIKYPRK------------GHVEDVLLIMDVYKLALSFQLCRLE--QLCR 567
             ...|:.|...|.|.:::..:|            ..|:.:::|.:..|.: :||..||:  ::.:
Yeast   549 PKNLFDDLNLNLQTLRLEAQQKELETARHISQLEKEVQRLMVIKEASKDS-NFQTARLKNLEIQK 612

Human   568 QYIEASV-DLQNVLVVCESAARLQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLI-----V 626
            .::|:.: ||:|:|:|       :|||..:.|....::.   |.:....|...:...:|     .
Yeast   613 TFLESRINDLKNLLMV-------KLSQASKLCDQITIQN---NGLKTCSEHVTIKRDIIDLENKC 667

Human   627 EIVRRKQQPPPRTPLDQPVDIGTSLIQDMK-------AYLEGAGAEFCDITLLLDGHPRPAHKAI 684
            ::::|:.:               .|:.:|:       .||..:.   |.:..||..:|..|....
Yeast   668 DVLKRQNE---------------ILVNNMQKITPELHTYLNESS---CYLGKLLKSYPTSARPPS 714

Human   685 LAARSSYFEAMFRSFMPED--GQVNISIGEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPY 747
            ....:..:|        :|  .::...|.||..:.:|.|.:  ::...::| ...|||
Yeast   715 SEKDNQIYE--------KDSLNKIEKVINEMHETVRAKEKL--HLETQKLN-DERDSL------- 761

Human   748 YYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQALDMKRHCLHIIVHQFTKVSKLPTLRSL 812
                         :.||..|....:.|:.| :...::::|:.:..:|:...:..|..|    .:.
Yeast   762 -------------RANLLDNNNKLDALRKL-SDGSSKSMDLTKKAIHLSQSELEKYRK----NND 808

Human   813 SQQLLLDIIDSLASHISDKQ 832
            ..|..:|.|.:..:...|||
Yeast   809 DLQKEIDRIKTEQAEQDDKQ 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LZTR1	NP_006758.2	NanM	54..420	CDD:442289	86/391 (22%)
		KELCH repeat	68..114	CDD:276965	11/59 (19%)
		Kelch 1. /evidence=ECO:0000255	79..128		15/62 (24%)
		KELCH repeat	118..172	CDD:276965	16/53 (30%)
		Kelch 2. /evidence=ECO:0000255	130..185		16/54 (30%)
		Kelch 3. /evidence=ECO:0000255	187..238		13/52 (25%)
		Kelch 4. /evidence=ECO:0000255	239..285		12/45 (27%)
		KELCH repeat	284..326	CDD:276965	8/42 (19%)
		Kelch 5. /evidence=ECO:0000255	295..341		7/46 (15%)
		Kelch 6. /evidence=ECO:0000255	399..450		11/62 (18%)
		BTB1_POZ_LZTR1	420..571	CDD:349617	31/195 (16%)
		BACK1_LZTR1	575..633	CDD:350580	13/62 (21%)
		BTB2_POZ_LZTR1	647..772	CDD:349618	23/133 (17%)
		BACK2_LZTR1	768..828	CDD:350581	9/59 (15%)
KEL2	NP_011754.3	NanM	77..391	CDD:442289	78/345 (23%)
		KELCH repeat	142..190	CDD:276965	14/49 (29%)
		KELCH repeat	257..308	CDD:276965	13/54 (24%)
		KELCH repeat	310..353	CDD:276965	8/42 (19%)
		SMC_N	<603..872	CDD:481474	51/290 (18%)