Protein Alignment LZTR1 and lztr1

DIOPT Version :10

• Sequence 1: NP_006758.2
• Gene: LZTR1 / 8216
• HGNCID: 6742
• Length: 840
• Species: Homo sapiens
• Sequence 2: NP_001074074.2
• Gene: lztr1 / 792832
• ZFINID: ZDB-GENE-030131-9564
• Length: 783
• Species: Danio rerio
• Alignment Length: 832
• Identity: 680/832 - (81%)
• Similarity: 720/832 - (86%)
• Gaps: 63/832 - (7%)

Human    17 AGGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIY 81
            |...:|||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
Zfish     7 AMSCKSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYRDAIY 71

Human    82 VFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNL 146
            ||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish    72 VFGGDNGKNMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNL 136

Human   147 KNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRE 211
            ||||||||||||||||||||:|||| |||||||||||:|||||||||||||||||||||||||||
Zfish   137 KNKNDLFEYKFATGQWTEWKVEGRL-VARSAHGATVYNDKLWIFAGYDGNARLNDMWTIGLQDRE 200

Human   212 LTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRG 276
            ...|||:.||||||||||||||||||||||||||||||||||||||||||...||||||||||||
Zfish   201 QAYWEEIEQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKGHIWTRIPTEHLLRG 265

Human   277 SPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERA 341
            |||||||||||||||||||||||||||||||||||||||||.|||||:|||.|
Zfish   266 SPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDSQTWEVIQPSID------------ 318

Human   342 CASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGT 406
                                                    ||:||||||||||||.|||||||||
Zfish   319 ----------------------------------------SEMPSGRLFHAAAVIHDAMYIFGGT 343

Human   407 VDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEECVQGHVAIVTARSRWLR 471
            ||||:|||||||||||||||||||||||:|||:||||||||:|||:||.|.||:||||||.:|||
Zfish   344 VDNNVRSGEMYRFQFSCYPKCTLHEDYGKLWENRQFCDVEFILGEREEKVLGHIAIVTARCKWLR 408

Human   472 RKITQARERLAQK--------LEQEAAPVPREAPGVAAGGARPPLLHVAIREAEARPFEVLMQFL 528
            :||.|||:|..||        .::..:...::..|.::.|  ||||.|:||||:|:|||||||||
Zfish   409 KKILQARDRQKQKSKLECNEESDESGSGSQKDCSGRSSRG--PPLLEVSIREADAQPFEVLMQFL 471

Human   529 YTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLSQ 593
            |||||:|||:|||:|||||||||||||||:|.||||||.|||||||||||||.|||:|.:|||.|
Zfish   472 YTDKIQYPRRGHVQDVLLIMDVYKLALSFKLSRLEQLCVQYIEASVDLQNVLSVCENADKLQLDQ 536

Human   594 LKEHCLNFVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPLDQPVDIGTSLIQDMKAY 658
            ||||||||||||||||||||.||||.||:||||||||||||||||...||||||||||:||||||
Zfish   537 LKEHCLNFVVKESHFNQVIMTKEFEHLSTPLIVEIVRRKQQPPPRVYSDQPVDIGTSLVQDMKAY 601

Human   659 LEGAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESM 723
            |||||.|||||.||||||||||||||||||||||||||||||||||||||||||||||.||||||
Zfish   602 LEGAGHEFCDIILLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSTQAFESM 666

Human   724 LRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQALDM 788
            |||||||:|:||||||||||||||||||.||||||||||||||||||:|||||||||||||||||
Zfish   667 LRYIYYGDVDMPPEDSLYLFAAPYYYGFSNNRLQAYCKQNLEMNVTVENVLQILEAADKTQALDM 731

Human   789 KRHCLHIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQCAELGADI 840
            |:|||||||||||||||||.||||||.||||||||||||||||||.|:.:||
Zfish   732 KKHCLHIIVHQFTKVSKLPNLRSLSQPLLLDIIDSLASHISDKQCTEMSSDI 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LZTR1	NP_006758.2	NanM	54..420	CDD:442289	294/365 (81%)
		KELCH repeat	68..114	CDD:276965	43/45 (96%)
		Kelch 1. /evidence=ECO:0000255	79..128		47/48 (98%)
		KELCH repeat	118..172	CDD:276965	52/53 (98%)
		Kelch 2. /evidence=ECO:0000255	130..185		52/54 (96%)
		Kelch 3. /evidence=ECO:0000255	187..238		45/50 (90%)
		Kelch 4. /evidence=ECO:0000255	239..285		42/45 (93%)
		KELCH repeat	284..326	CDD:276965	39/41 (95%)
		Kelch 5. /evidence=ECO:0000255	295..341		32/45 (71%)
		Kelch 6. /evidence=ECO:0000255	399..450		46/50 (92%)
		BTB1_POZ_LZTR1	420..571	CDD:349617	107/158 (68%)
		BACK1_LZTR1	575..633	CDD:350580	49/57 (86%)
		BTB2_POZ_LZTR1	647..772	CDD:349618	117/124 (94%)
		BACK2_LZTR1	768..828	CDD:350581	55/59 (93%)
lztr1	NP_001074074.2	NanM	44..357	CDD:442289	294/365 (81%)
		KELCH repeat	58..104	CDD:276965	43/45 (96%)
		KELCH repeat	108..161	CDD:276965	51/52 (98%)
		KELCH repeat	273..315	CDD:276965	39/41 (95%)
		BTB1_POZ_LZTR1	357..514	CDD:349617	107/158 (68%)
		BACK1_LZTR1	518..576	CDD:350580	49/57 (86%)
		BTB2_POZ_LZTR1	590..715	CDD:349618	117/124 (94%)
		BACK2_LZTR1	711..771	CDD:350581	55/59 (93%)