Protein Alignment LZTR1 and Lztr1

DIOPT Version :10

• Sequence 1: NP_006758.2
• Gene: LZTR1 / 8216
• HGNCID: 6742
• Length: 840
• Species: Homo sapiens
• Sequence 2: XP_006248769.1
• Gene: Lztr1 / 360745
• RGDID: 1309100
• Length: 862
• Species: Rattus norvegicus
• Alignment Length: 803
• Identity: 761/803 - (94%)
• Similarity: 768/803 - (95%)
• Gaps: 3/803 - (0%)

Human     1 MAGPGSTGGQIGAAALAGGARSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVG 65
            |||   :||..|..||.||..||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MAG---SGGPTGPGALTGGVSSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVG 62

Human    66 ARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSM 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    63 ARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSM 127

Human   131 FVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDG 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   128 FVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDG 192

Human   196 NARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEF 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   193 NARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEF 257

Human   261 KDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQ 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   258 KDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQ 322

Human   326 PSSDSEVGGAEVPERACASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLF 390
            ||||||||||||||||.:|||..|||.|||..||||||||||||||||.|||...||||||||||
  Rat   323 PSSDSEVGGAEVPERASSSEEASTLTSEERSSFKKSRDVFGLDFGTTSTKQPVHLASELPSGRLF 387

Human   391 HAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEEC 455
            ||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
  Rat   388 HAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWEGRQFCDVEFVLGEKEEC 452

Human   456 VQGHVAIVTARSRWLRRKITQARERLAQKLEQEAAPVPREAPGVAAGGARPPLLHVAIREAEARP 520
            |||||||||||||||||||.||||.||||||::.|..|:||||...|.||||||.||||||||||
  Rat   453 VQGHVAIVTARSRWLRRKIVQAREWLAQKLEEDGALAPKEAPGSTVGRARPPLLRVAIREAEARP 517

Human   521 FEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCES 585
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||.
  Rat   518 FEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLAVCEC 582

Human   586 AARLQLSQLKEHCLNFVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPLDQPVDIGTS 650
            ||||||.|||||||||:||||||||||||||||||||||||||||||||||||||.|||||||||
  Rat   583 AARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPSDQPVDIGTS 647

Human   651 LIQDMKAYLEGAGAEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVP 715
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   648 LIQDMKAYLEGAGSEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVP 712

Human   716 SRQAFESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAA 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   713 SRQAFESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAA 777

Human   781 DKTQALDMKRHCLHIIVHQFTKV 803
            |||||||||||||||||||||||
  Rat   778 DKTQALDMKRHCLHIIVHQFTKV 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LZTR1	NP_006758.2	NanM	54..420	CDD:442289	354/365 (97%)
		KELCH repeat	68..114	CDD:276965	45/45 (100%)
		Kelch 1. /evidence=ECO:0000255	79..128		48/48 (100%)
		KELCH repeat	118..172	CDD:276965	53/53 (100%)
		Kelch 2. /evidence=ECO:0000255	130..185		54/54 (100%)
		Kelch 3. /evidence=ECO:0000255	187..238		50/50 (100%)
		Kelch 4. /evidence=ECO:0000255	239..285		45/45 (100%)
		KELCH repeat	284..326	CDD:276965	41/41 (100%)
		Kelch 5. /evidence=ECO:0000255	295..341		45/45 (100%)
		Kelch 6. /evidence=ECO:0000255	399..450		49/50 (98%)
		BTB1_POZ_LZTR1	420..571	CDD:349617	136/150 (91%)
		BACK1_LZTR1	575..633	CDD:350580	53/57 (93%)
		BTB2_POZ_LZTR1	647..772	CDD:349618	123/124 (99%)
		BACK2_LZTR1	768..828	CDD:350581	36/36 (100%)
Lztr1	XP_006248769.1	NanM	51..417	CDD:442289	354/365 (97%)
		KELCH repeat	65..111	CDD:276965	45/45 (100%)
		KELCH repeat	115..169	CDD:276965	53/53 (100%)
		KELCH repeat	281..323	CDD:276965	41/41 (100%)
		BTB1_POZ_LZTR1	417..568	CDD:349617	136/150 (91%)
		BACK1_LZTR1	572..630	CDD:350580	53/57 (93%)
		BTB2_POZ_LZTR1	644..769	CDD:349618	123/124 (99%)
		BACK2_LZTR1	765..>800	CDD:350581	34/34 (100%)