Protein Alignment LZTR1 and lztr1

DIOPT Version :10

• Sequence 1: NP_006758.2
• Gene: LZTR1 / 8216
• HGNCID: 6742
• Length: 840
• Species: Homo sapiens
• Sequence 2: NP_001121508.1
• Gene: lztr1 / 100158621
• XenbaseID: XB-GENE-998506
• Length: 778
• Species: Xenopus tropicalis
• Alignment Length: 827
• Identity: 676/827 - (81%)
• Similarity: 719/827 - (86%)
• Gaps: 59/827 - (7%)

Human    21 RSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGG 85
            :||||||||||||||||||||||||||||:|||||||.|||||||||||||||||||||||||||
 Frog     4 KSKVAPSVDFDHSCSDSVEYLTLNFGPFESVHRWRRLLPCDEFVGARRSKHTVVAYKDAIYVFGG 68

Human    86 DNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKN 150
            ||||.||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
 Frog    69 DNGKNMLNDLLRFDVKDCSWCRAFTTGSPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKN 133

Human   151 DLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCW 215
            ||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||:||||
 Frog   134 DLFEYKFATGLWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRDLTCW 198

Human   216 EEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPP 280
            ||:.|||||||||||||||||||||||||||||||||||||||||.:|.||||||||||||||||
 Frog   199 EEIEQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFSEKVWTRIPTEHLLRGSPPP 263

Human   281 PQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEVPERACASE 345
            |||||||||||||||||||||||||||||||||||||.|:|||:|.|
 Frog   264 PQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDSQSWEVIQAS------------------ 310

Human   346 EVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVISDAMYIFGGTVDNN 410
                                              |.|||||||||||||||:|||||||||||||
 Frog   311 ----------------------------------PDSELPSGRLFHAAAVIADAMYIFGGTVDNN 341

Human   411 IRSGEMYRFQFSCYPKCTLHEDYGRLWESRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKIT 475
            :|||||||||||||||||||||||||:|::|||||||:||||||.|:||.||||||.:|||:||.
 Frog   342 VRSGEMYRFQFSCYPKCTLHEDYGRLFENQQFCDVEFILGEKEERVRGHTAIVTARCKWLRKKIM 406

Human   476 QARERLAQKLEQE-------AAPVPREAPGVAAGGARPPLLHVAIREAEARPFEVLMQFLYTDKI 533
            |||||..|||:||       :......|..........|:|.|.||:|||||||:||||||||||
 Frog   407 QARERQKQKLKQEPEDEMQNSQQKTESACSQVKLSRSQPMLEVIIRDAEARPFELLMQFLYTDKI 471

Human   534 KYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLSQLKEHC 598
            ||||||||||||||||||||||.|:|.||||||.|||||||||||||.|||:|.:|||.:|||||
 Frog   472 KYPRKGHVEDVLLIMDVYKLALHFKLSRLEQLCVQYIEASVDLQNVLGVCENANKLQLDELKEHC 536

Human   599 LNFVVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPLDQPVDIGTSLIQDMKAYLEGAG 663
            ||||||||||||||||||||.|||.|||||||||||||.|...||||||||||:|||||||||||
 Frog   537 LNFVVKESHFNQVIMMKEFEHLSSSLIVEIVRRKQQPPLRIHSDQPVDIGTSLVQDMKAYLEGAG 601

Human   664 AEFCDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRYIY 728
            .:||||||||||||||||:||||||||||||||||||||||||||||||||||:|||||:|||||
 Frog   602 NDFCDITLLLDGHPRPAHQAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSKQAFESLLRYIY 666

Human   729 YGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQALDMKRHCL 793
            |||||||||||||||:|||||||::|||||||:|||||||||:||||||||||||||:|||:|||
 Frog   667 YGEVNMPPEDSLYLFSAPYYYGFFSNRLQAYCRQNLEMNVTVENVLQILEAADKTQAVDMKKHCL 731

Human   794 HIIVHQFTKVSKLPTLRSLSQQLLLDIIDSLASHISDKQCAELGADI 840
            ||||||||||:|||.||.|||.||::||:|||||||||||||||:||
 Frog   732 HIIVHQFTKVAKLPNLRLLSQPLLINIIESLASHISDKQCAELGSDI 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LZTR1	NP_006758.2	NanM	54..420	CDD:442289	296/365 (81%)
		KELCH repeat	68..114	CDD:276965	44/45 (98%)
		Kelch 1. /evidence=ECO:0000255	79..128		46/48 (96%)
		KELCH repeat	118..172	CDD:276965	52/53 (98%)
		Kelch 2. /evidence=ECO:0000255	130..185		53/54 (98%)
		Kelch 3. /evidence=ECO:0000255	187..238		47/50 (94%)
		Kelch 4. /evidence=ECO:0000255	239..285		42/45 (93%)
		KELCH repeat	284..326	CDD:276965	38/41 (93%)
		Kelch 5. /evidence=ECO:0000255	295..341		29/45 (64%)
		Kelch 6. /evidence=ECO:0000255	399..450		45/50 (90%)
		BTB1_POZ_LZTR1	420..571	CDD:349617	110/157 (70%)
		BACK1_LZTR1	575..633	CDD:350580	49/57 (86%)
		BTB2_POZ_LZTR1	647..772	CDD:349618	114/124 (92%)
		BACK2_LZTR1	768..828	CDD:350581	49/59 (83%)
lztr1	NP_001121508.1	NanM	51..351	CDD:442289	283/351 (81%)
		KELCH repeat	51..97	CDD:276965	44/45 (98%)
		KELCH repeat	101..155	CDD:276965	52/53 (98%)
		KELCH repeat	267..311	CDD:276965	40/95 (42%)
		BTB1_POZ_LZTR1	351..509	CDD:349617	110/157 (70%)
		BACK1_LZTR1	513..571	CDD:350580	49/57 (86%)
		BTB2_POZ_LZTR1	585..710	CDD:349618	114/124 (92%)
		BACK2_LZTR1	706..766	CDD:350581	49/59 (83%)