DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIN10 and par-1

DIOPT Version :9

Sequence 1:	NP_850488.1	Gene:	KIN10 / 821259	AraportID:	AT3G01090	Length:	535	Species:	Arabidopsis thaliana
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	180/526 - (34%)
Similarity:	272/526 - (51%)	Gaps:	88/526 - (16%)

- Green bases have known domain annotations that are detailed below.

plant     9 NLVSSTIDHRIFKSRMDGSGTGS-----RS-------GVESILPNYKLGRTLGIGSFGRVKIAEH 61
            |::|:...|.....:...|..||     ||       ..|..:..|||.:|:|.|:|.:||:|:|
  Fly   208 NVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKH 272

plant    62 ALTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRLYEVIETPTDIYLVMEYVNSGE 126
            ..||.:|||||:::.:: |....:|:.||::|:::..||:|::|::||||...:||:|||.:.||
  Fly   273 LPTGKEVAIKIIDKTQL-NPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGE 336

plant   127 LFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKCNVKIADFGLSNIMR 191
            :|||:|..||::|.|||..|:||:|.|:|||:..::|||||.|||||||:.|:||||||.||...
  Fly   337 VFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFT 401

plant   192 DGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGI 256
            .|..|.|.||||.|||||:..||.|.||||||||.|||||.|:.|:||||...:..|.:::..|.
  Fly   402 PGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGK 466

plant   257 YTLPSHLSPGARDLIPRMLVVDPMKRVTIPEIRQHPWF-----QAHLPRYLAVPPPDTVQQAKKI 316
            |.:|.::|....:|:.:.||::|.||.::..|....|.     :..|..|:. |..|..
  Fly   467 YRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIE-PKADLA------ 524

plant   317 DEEILQEVINMGFDRNHLIESLRNRTQNDGTVTYYL-----------------------ILDNRF 358
            |.:.::.::.||::|:.:..||.....:|...||.|                       |..|..
  Fly   525 DPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDA 589

plant   359 RASSGYLGAEFQETMEGTPRMHPAESVASPVSHRLPGLMEYQGVGLRSQYPVER-KWALGLQSRA 422
            .|::|                  :.||.|| :||  |:  ::.:...|..|..| ...:|..:.|
  Fly   590 GANAG------------------SASVQSP-THR--GV--HRSISASSTKPSRRASSGVGPTNAA 631

plant   423 HPREIMTEVLKALQDLNVCWKKIGHYNMKCRWVPNSSAD--GMLSNSMHDNNYFGDESSIIENEA 485
            ......|..:.|:...|       :||     ...|:||  .:.||....|..  |.::|.||.|
  Fly   632 ATVAAATGAVGAVNPSN-------NYN-----AAGSAADRASVGSNFKRQNTI--DSATIKENTA 682

plant   486 AVKSPN 491
            .:.:.|
  Fly   683 RLAAQN 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIN10	NP_850488.1	STKc_AMPK_alpha	39..294	CDD:270981	123/254 (48%)
		S_TKc	42..294	CDD:214567	123/251 (49%)
		UBA_SnRK1_plant	316..356	CDD:270520	11/62 (18%)
		AMPKA_C	411..532	CDD:213378	20/84 (24%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	123/252 (49%)
		S_TKc	253..504	CDD:214567	123/251 (49%)
		UBA_MARK_Par1	525..563	CDD:270522	10/37 (27%)
		MARK1-3_C	839..936	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910