DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NCOA3 and Clk

DIOPT Version :10

Sequence 1:NP_858045.1 Gene:NCOA3 / 8202 HGNCID:7670 Length:1424 Species:Homo sapiens
Sequence 2:NP_001014576.1 Gene:Clk / 38872 FlyBaseID:FBgn0023076 Length:1027 Species:Drosophila melanogaster


Alignment Length:1469 Identity:284/1469 - (19%)
Similarity:466/1469 - (31%) Gaps:586/1469 - (39%)


- Green bases have known domain annotations that are detailed below.


Human    34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIR---QIKEQGKTISNDDDV 95
            ||:||:|.:..:.:|:.|||.:       :.|.||..:||.|:..::   :..::.|......|.
  Fly    24 EKKRRDQFNSLVNDLSALISTS-------SRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQQDW 81

Human    96 QKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNI 160
            :.|.:|:        |....|:|::||||:.|.:..|:|.:.||::|..|.|..:||.|.::|::
  Fly    82 KPAFLSN--------DEYTHLMLESLDGFMMVFSSMGSIFYASESITSQLGYLPQDLYNMTIYDL 138

Human   161 LHEEDRKDFL------------KNLPKSTVNGVSWTNETQR--QKSHTFNCRMLMKTPHDILEDI 211
            .:|.|.:..|            :....|:.|.:::....:|  .:....|...|:|.......|.
  Fly   139 AYEMDHEALLNIFMNPTPVIEPRQTDISSSNQITFYTHLRRGGMEKVDANAYELVKFVGYFRNDT 203

Human   212 NASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGK 276
            |.|               :...:.:..|.:.|..::         .|.|..||.:     ::..|
  Fly   204 NTS---------------TGSSSEVSNGSNGQPAVL---------PRIFQQNPNA-----EVDKK 239

Human   277 VVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQS--WSQKRHYQEAYL-NGHAETPV------ 332
            :|.:.|..:::      ..:||.     .|:.|..|  ::.|...:..:| ..|...|:      
  Fly   240 LVFVGTGRVQN------PQLIRE-----MSIIDPTSNEFTSKHSMEWKFLFLDHRAPPIIGYMPF 293

Human   333 ----------YRFSLADGTIV-------TAQTKSKLFRNPVTNDRHGFVST-HFLQREQNGYRPN 379
                      |.|...|..:.       |.:.||..:|......:..::.| :::...|...:|:
  Fly   294 EVLGTSGYDYYHFDDLDSIVACHEELRQTGEGKSCYYRFLTKGQQWIWLQTDYYVSYHQFNSKPD 358

Human   380 PNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTP 444
                       ...|...|              .|.|..|.|....||.||              
  Fly   359 -----------YVVCTHKV--------------VSYAEVLKDSRKEGQKSG-------------- 384

Human   445 GPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMAS 509
                       |:|                        |..|.||.|:              :||
  Fly   385 -----------NSN------------------------SITNNGSSKV--------------IAS 400

Human   510 SGNTGNHSFSSSSLSALQAISEGVGTSLL-STLSSPG-------PKLDNSP--NMNITQPSKVSN 564
            :|.:...:.::::|...:..|:.:.::|| ::|:|.|       |.:|:||  :.:..|||.   
  Fly   401 TGTSSKSASATTTLRDFELSSQNLDSTLLGNSLASLGTETAATSPAVDSSPMWSASAVQPSG--- 462

Human   565 QDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTC-S 628
                     .|..||:               |.|:.:|..|..:..| :..|..:|      | .
  Fly   463 ---------SCQINPL---------------KTSRPASSYGNISSTG-ISPKAKRK------CYF 496

Human   629 SDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGN 693
            .::||:.|       .|...|:.||||...:.:.    |||.|....|..:|.||      :|.:
  Fly   497 YNNRGNDS-------DSTSMSTDSVTSRQSMMTH----VSSQSQRQRSHHREHHR------ENHH 544

Human   694 SPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQ 758
            :.:.                     .::.:|:|...:::::..               .::||.|
  Fly   545 NQSH---------------------HHMQQQQQHQNQQQQHQQ---------------HQQLQQQ 573

Human   759 VEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSH 823
            ::..                                                             
  Fly   574 LQHT------------------------------------------------------------- 577

Human   824 LGTKQQVFQGTNSLGLKSSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGN 888
            :||.:.|    ..|.:.|:|                  :..|      |...||. |..|:  .:
  Fly   578 VGTPKMV----PLLPIASTQ------------------IMAG------NACQFPQ-PAYPL--AS 611

Human   889 PRMMDSQENYGSSMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPA 953
            |:::                     .|:.            :||          ..|.|::|...
  Fly   612 PQLV---------------------APTF------------LEP----------PQYLTAIPMQP 633

Human   954 LGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSME 1018
            :....|..|:.| .:|     :|.|..||   |..:.|    .| .|:...:||           
  Fly   634 VIAPFPVAPVLS-PLP-----VQSQTDML---PDTVVM----TP-TQSQLQDQL----------- 673

Human  1019 QVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVN 1083
            |..|         :.|..|:     |:.|::.|.:.:||                       |::
  Fly   674 QRKH---------DELQKLI-----LQQQNELRIVSEQL-----------------------LLS 701

Human  1084 QGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMNQMNQQGNF 1148
            :...|:|...  .|.....|.....|..|    |.|   |.|.:..|.    |::..|.||.| |
  Fly   702 RYTYLQPMMS--MGFAPGNMTAAAVGNLG----ASG---QRGLNFTGS----NAVQPQFNQYG-F 752

Human  1149 PLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTAGGAAVMRPMMQPQ 1213
            .|       |..:......:|:.||.||.|..|...|..:|                        
  Fly   753 AL-------NSEQMLNQQDQQMMMQQQQNLHTQHQHNLQQQ------------------------ 786

Human  1214 VSSQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQ 1278
                          .:|...|..|.:||.  ...|||||||||||||||||||||||||||||..
  Fly   787 --------------HQSHSQLQQHTQQQH--QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQL 835

Human  1279 AFSPPPNVTASPSMDGLLA----------GPTMPQAP--------PQQFPYQPNYGMGQQPDPAF 1325
            ......::.....:|.:.|          |......|        .|.:....|...|.|.:.  
  Fly   836 QLQQQNDILLREDIDDIDAFLNLSPLHSLGSQSTINPFNSSSNNNNQSYNGGSNLNNGNQNNN-- 898

Human  1326 GRVSSPPN----------AMMSSRMGPSQNPMMQHPQAASIYQS--SEMKGWPSGNLARNSSFSQ 1378
            .|.|:||.          ..|::...||.|..|......|..||  ::|......||.:.....|
  Fly   899 NRSSNPPQNNNEDSLLSCMQMATESSPSINFHMGISDDGSETQSEDNKMMHTSGSNLVQQQQQQQ 963

Human  1379 ------QQFAHQGNPAVYSMVHMNGSSGHMGQMNMNPMP 1411
                  ||...|.|....|...:|..:     .|.|.:|
  Fly   964 QQQQILQQHQQQSNSFFSSNPFLNSQN-----QNQNQLP 997

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NCOA3NP_858045.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38 2/3 (67%)
bHLH-PAS_NCoA3_SRC3 29..101 CDD:381519 18/69 (26%)
PAS 116..173 CDD:214512 21/68 (31%)
PAS_11 265..375 CDD:464214 21/136 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..493 15/84 (18%)
NCOA_u2 459..572 CDD:465223 22/122 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..520 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..674 36/147 (24%)
SRC-1 616..704 CDD:462615 21/88 (24%)
LXXLL motif 1 685..689 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..730 2/20 (10%)
DUF4927 723..810 CDD:465083 5/86 (6%)
LXXLL motif 2 738..742 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 755..798 3/42 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 912..945 3/32 (9%)
Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9346901 1023..1093 10/69 (14%)
Nuc_rec_co-act 1045..1091 CDD:462608 6/45 (13%)
LXXLL motif 3 1057..1061 1/3 (33%)
Acetyltransferase 1097..1304 63/216 (29%)
polyglutamine repeats 1248..1276 27/27 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1273..1321 11/65 (17%)
DUF1518 1291..1348 CDD:462174 16/84 (19%)
ClkNP_001014576.1 bHLH-PAS_dCLOCK 11..86 CDD:381578 18/68 (26%)
PAS 93..153 CDD:214512 21/59 (36%)
PAS_11 265..368 CDD:464214 16/127 (13%)

Return to query results.
Submit another query.