Protein Alignment NCOA3 and tai

DIOPT Version :10

• Sequence 1: NP_858045.1
• Gene: NCOA3 / 8202
• HGNCID: 7670
• Length: 1424
• Species: Homo sapiens
• Sequence 2: NP_001245949.1
• Gene: tai / 34242
• FlyBaseID: FBgn0041092
• Length: 2047
• Species: Drosophila melanogaster
• Alignment Length: 1980
• Identity: 404/1980 - (20%)
• Similarity: 614/1980 - (31%)
• Gaps: 772/1980 - (38%)

Human     2 SGLGENLDPLASDSRKRKLPCDT-----PGQGLTCSGEKRRREQESKYIEELAELISANLSDIDN 61
            |.:..|....|:..||.:...|:     ..|...|:.||||||.|:.|||:|:|:::.|... |.
  Fly   207 SPISANSANSATSGRKIRRKTDSKVNLPQSQINKCNNEKRRREAENGYIEQLSEILTLNKRG-DM 270

Human    62 FNVKPDKCAILKETVRQIRQIKEQGK---------------------TISNDDD----------- 94
            .:.||||.|||.:.||..|:|.::|:                     |.||:::
  Fly   271 TSTKPDKAAILNQVVRTYREICDKGQNRDISSTSTNNNNSTTTTNNNTNSNNNNNTSKPQATSTR 335

Human    95 -------------VQKADVSSTGQGVIDKDSLGPLLL-----------QALDGF-------LFVV 128
                         ||:.:||||...:.:     |.||           :||:.:       |..|
  Fly   336 CSRCATDNCSIHPVQQGEVSSTEPPLPE-----PSLLLGQVPEISAYFEALEHYISGVGWVLLQV 395

Human   129 NRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRK------DFLKNLPK------------ 175
            |.:|.|...::|:...:.|::::|.:..:|..|:..|..      :.:.|.|.
  Fly   396 NANGIIESCTQNIRDLIGYEKQELYHQPLYMYLYSGDHAKLEPIINTMYNNPNGGNSNSANNSGP 460

Human   176 -----STVNGVSW--------TNETQ-------------------RQKSHTFNCRMLMKTPHDIL 208
                 .|..|| |        .|.:|                   :::|.:...|||:|......
  Fly   461 GGSSAGTSAGV-WGDLEELNNGNASQGSNSSGAGGLGGAGGAAAGKKRSISTKVRMLVKDTRTAT 524

Human   209 EDINASPE--MRQ-----RYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFP----- 261
            :..:...|  :||     :||.:...|     |.:::..|..|.::|:   ||..|...|
  Fly   525 QTSSNCEEKPLRQSGHQDKYEEVVLIA-----APVKDDADASSSVLCL---ITRPEDESPLEINI 581

Human   262 -----SNP-ESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQ 320
                 ..| |....:.|:.||::.:|..:||...:...:..:.|..|.....:|..  :.|.|.:
  Fly   582 QQHVQQQPIEQMTFKLDIHGKILTLDPTALREPFKQHLQTWVGRLWQDLCHPHDLS--TLKSHLR 644

Human   321 EAYLNGHAETP-----------VYRFSL-ADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQ 373
            :...:..|.:|           .:|..| |....|..:..|:||.|....:....:|...|...:
  Fly   645 DIQDSASANSPGAGAGTSVVSRPFRLRLGAPDVYVHVKANSRLFLNQTPGEGDFIMSVQTLLNSE 709

Human   374 NGYRPNPNPVGQG---------IRP------------PMAGCNSSVG-GMSMSPNQGLQMPSSRA 416
            |....:....|.|         :.|            .|.|.:...| |.|.||.....:|:...
  Fly   710 NDMNSSNTGAGSGGLGLGQLCAMAPSPSLASSLLSSLSMDGLHGGTGSGSSSSPAASGMLPTHLL 774

Human   417 YGLADPSTTGQMSGARYGGSSNIASLTP------------GPGMQ-------------------- 449
            .||        :.|.:.||..|....|.            |.|:|
  Fly   775 GGL--------VGGGQQGGGGNSTQTTSVGGPLMSSAIINGTGLQQQQQQQQRSGASSSASSSAN 831

Human   450 --------SPSSYQNNNYG---------LNMSS---PPHGSPGL----APNQQNIMISPRNRGSP 490
                    ||:..:::.||         .:.||   .|.|..|.    .||.:..:.:|.:...|
  Fly   832 ALVNAFTASPAPAEHSFYGSDTFEFDIAAHSSSFELDPSGGVGAWTDSRPNSRASVATPVSTPRP 896

Human   491 KIASHQFSP----------------VAGVHSPM----ASSGNTGN---HSFSSSSLSALQAISE- 531
            . :.|.|||                .|.:.||.    |..||.|.   |||.||.:...:.:.:
  Fly   897 P-SGHGFSPAVCASPATPYQLSSHSAASLPSPQSNASAGGGNYGGFNFHSFDSSDVKPEKDVQQQ 960

Human   532 -----------------------GVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGF 573
                                   |||..|||...    :...:|..   |..:...|:|...|
  Fly   961 QNQQQSNNNSSSSNPLLGGGLPNGVGGMLLSQQQ----QQQQTPPQ---QQQQQQQQESSERL-- 1016

Human   574 YCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQR------------------GPLESKG--- 617
               ::.:..|...:.....|.|.| |....||:|.::                  ||:.|.|
  Fly  1017 ---RHLLTKSQSMAGGLGGLGDDE-KYFKPEGSEEEKHASGGFKMGGQPGGMGMFGPMGSMGRGV 1077

Human   618 ------HK-------KLLQLLTCSSDD-------RGHSSLTNSPLDSSCKESSV--SVTSPSGVS 660
                  ||       .||:||...|:|       .|..|:.||      ::|.:  .:.:|.|.|
  Fly  1078 GNSSMLHKAGNSQNPMLLKLLNEKSEDDDGNGSGGGPGSMNNS------RQSELMRQLKNPDGGS 1136

Human   661 -----SSTSGGVSS-------------TSNMHGSL------------------LQEKHRILHKLL 689
                 :|.||.:|:             :.|...||                  |..::::|.|||
  Fly  1137 HGMHRNSASGNMSTEDLKAMLKIQSDPSLNRKRSLNEPDDDPSAKRSEDKPSKLCTQNKMLAKLL 1201

Human   690 Q---------NGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRD 745
            |         |...|.:| |...:.|....|| |....||::......||...|    |....:.
  Fly  1202 QNPPKIPKAPNPEQPLQV-KTLPDITSSTVSS-TLAAPGNLISAGSTGPKAAAN----RNRKQQQ 1260

Human   746 DPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEK----------------------------- 781
            .......::.|.||.|:.::..|...:.:..|.|::
  Fly  1261 QQQQQQQQQQQQQVAGIPSQQQQQQPNDVYLSQQQQQQLQSPQLAFQHQQLATTATTSITTAAST 1325

Human   782 -------------------------------DPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNN 815
                                           |..|.|....|.|...|...:::.|:.|:.|.|:
  Fly  1326 SAAAAAAAAILGEGDSELSKLLDSVMEYYPDDTPIVTNAPSEASAINDIQKSLMLDVESAAFGND 1390

Human   816 SISSNGSHLGTKQQVFQGTNS----LGLKSSQSVQSIR-------PPYNRAVS------------ 857
               .|...:.|:||..|....    |.|:.:|..|..|       |.|...::
  Fly  1391 ---LNQQLMMTQQQQHQQQQQQQQLLALQLAQQQQQQRQQHLQQPPAYPGMLNMQQQQHQQQQQQ 1452

Human   858 --------LDSPVSVGSS-----PPV--------KNISAFP---MLPKQPMLGG----------- 887
                    |::..:.|:.     ||:        .|..|.|   :||.|..|..
  Fly  1453 NQQHIMQRLEAMRNQGNQGFQRPPPMYPARGRGPMNAVATPGGVVLPAQQQLRNIRQQQQLAAAQ 1517

Human   888 -NPRMMDSQE---------------------------------------NYGS---SMGGPNRNV 909
             ..|::..|:                                       |.||   :.|.||.::
  Fly  1518 QKERLLQQQQKQQLLVPENASEYWGNSNLQLIIKLIVSYILAGMNAGLNNIGSLLNTTGAPNVSL 1582

Human   910 TVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPTLPLRSNSIPGARPV 974
            :.|..||..... ||.....|:...|.....|   |:   |:|..|.: |..|.     ||.|..
  Fly  1583 SRTNLPSDAQLS-PNFAQTLMQQQLSPGRSAP---YS---PQPNQGYA-PQFPQ-----PGQRLS 1634

Human   975 LQQQQQMLQMRPGEIPM-------------GMGANPYGQAAASNQLG------SW---------P 1011
            .|||||:.|.:...:..             |....|:|..:.....|      .|         |
  Fly  1635 PQQQQQLSQQQQNNVQQQQLAYQQQQVGDGGRSNTPFGSNSGMQSPGMQNSPQQWGSGGGGGGGP 1699

Human  1012 DGMLSMEQVSHG-TQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRA 1075
            .|.|........ .|:.|:|...|.. |.|.:..:.|.::|                      |.
  Fly  1700 GGPLPSGNAGRTLQQHNPMLIAQLQG-VSPYNARQYQQNQR----------------------RG 1741

Human  1076 LGIPELVNQG-----QALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSF 1135
            |..|..|..|     ||...:|::||||          |..|.|.|.......||    .||| :
  Fly  1742 LNSPGAVGPGGNPAAQAALQRQNSFQGQ----------GGGGATTPDGSGVGFGG----PQSP-Y 1791

Human  1136 NSMMNQMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTA 1200
            .:.:|...||                           || ||||.|..:.|:.|.|.
  Fly  1792 GTNVNVFQQQ---------------------------QL-QRLQRQGSVPQATQHLP-------- 1820

Human  1201 GGAAVMRPMMQPQVSSQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQ 1265
             |:        |:..|..|..|                   ..........||||||||||||||
  Fly  1821 -GS--------PRFGSSPGSSN-------------------NTDSSAAAGNQQQQQQQQQQQQQQ 1857

Human  1266 QQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGRVSS 1330
            .||||.||.....:.||.|:  ..|:|.|:                   .|||          |.
  Fly  1858 HQQQQHQQLMNGLSMSPHPH--PHPAMMGV-------------------GGMG----------SG 1891

Human  1331 PPNAMM-----SSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLA---RNSSFSQQQF------ 1381
            ..|.::     ....|.:.....|..||...|..::..| ..|::|   .||.|.:|:.
  Fly  1892 GGNGIIGLGGGGGNYGATLGGYGQSQQANDFYGRAQTAG-GGGSVAGGNANSEFVKQELRAVVSV 1955

Human  1382 -AHQGNPAVYSMVHMNGSSGHMGQMNMNPM 1410
             |.|...|......:.|.....||...:|:
  Fly  1956 RAQQAAAAATGGAGVGGGVAQRGQTPQSPL 1985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NCOA3	NP_858045.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		11/40 (28%)
		bHLH-PAS_NCoA3_SRC3	29..101	CDD:381519	32/116 (28%)
		PAS	116..173	CDD:214512	15/80 (19%)
		PAS_11	265..375	CDD:464214	24/121 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..493		24/140 (17%)
		NCOA_u2	459..572	CDD:465223	37/175 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..520		10/25 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	537..674		41/197 (21%)
		SRC-1	616..704	CDD:462615	34/157 (22%)
		LXXLL motif 1	685..689		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	709..730		5/20 (25%)
		DUF4927	723..810	CDD:465083	18/146 (12%)
		LXXLL motif 2	738..742		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	755..798		12/102 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	912..945		8/32 (25%)
		Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9346901	1023..1093		15/75 (20%)
		Nuc_rec_co-act	1045..1091	CDD:462608	9/50 (18%)
		LXXLL motif 3	1057..1061		0/3 (0%)
		Acetyltransferase	1097..1304		55/206 (27%)
		polyglutamine repeats	1248..1276		20/27 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1273..1321		10/47 (21%)
		DUF1518	1291..1348	CDD:462174	8/61 (13%)
tai	NP_001245949.1	bHLH_SF	239..291	CDD:469605	25/52 (48%)
		PAS	377..442	CDD:214512	13/64 (20%)
		PAS_11	590..711	CDD:464214	24/122 (20%)