Protein Alignment GDF5 and scw

DIOPT Version :9

• Sequence 1: NP_000548.2
• Gene: GDF5 / 8200
• HGNCID: 4220
• Length: 501
• Species: Homo sapiens
• Sequence 2: NP_001286088.1
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Alignment Length: 405
• Identity: 107/405 - (26%)
• Similarity: 166/405 - (40%)
• Gaps: 56/405 - (13%)

Human   112 PQTRQATARTVTPKGQLPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSL 176
            |.:.|.....:...|..|..:|.|...:..|.|||:...|....:||||...    ..|:..|..
  Fly    35 PLSEQMEMIDILDLGDRPRRQAEPNLHNSASKFLLEVYNEISEDQEPKEVLH----QRHKRSLDD 95

Human   177 YRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKD-GLLGAELR 240
            ...:|:.||:        |....|:|.:|..:.:.::..........|:.:.:..| .|:.|.||
  Fly    96 DILISNEDRQ--------EIASCNSILTFSSRLKPEQLDNELDMHITFNTNDVPVDLSLVQAMLR 152

Human   241 ILRKKPSDTAKPAAPGGGRAAQLKLSSCP--SGRQPAALLDVRSVPGLDGS-GWEVFDIWKLFRN 302
            |. |:||..        .|.|...:|...  ..||..:...:.||...... ||..|::....|.
  Fly   153 IY-KQPSLV--------DRRANFTVSVYRKLDNRQDFSYRILGSVNTTSSQRGWLEFNLTDTLRY 208

Human   303 FKNSAQLC----LELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKARSG 363
            :.::..|.    |.:...:...:....||...:|:|...|.  |:| |.....:|.....|.|..
  Fly   209 WLHNKGLQRRNELRISIGDSQLSTFAAGLVTPQASRTSLEP--FIV-GYFNGPELLVKIQKLRFK 270

Human   364 QDDKTVYEYLFSQRRKRRA--------PLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIA 420
            :|           ..||||        |.......||.::    |.|....|:||::...:|:||
  Fly   271 RD-----------LEKRRAGGGSPPPPPPPPVDLYRPPQS----CERLNFTVDFKELHMHNWVIA 320

Human   421 PLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNV 485
            |.::||:.|.|.|.|||.:.:..||||::||||:...|. .|..|||||.|..|:||...:.:.:
  Fly   321 PKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQPH-LPKPCCVPTVLGAITILRYLNEDII 384

Human   486 VYKQYEDMVVESCGC 500
            ...:|:..|.:.|||
  Fly   385 DLTKYQKAVAKECGC 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GDF5	NP_000548.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..169		15/56 (27%)
		TGFb_propeptide	145..344	CDD:279078	45/206 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..265		4/18 (22%)
		TGFB	400..501	CDD:214556	41/101 (41%)
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078	53/238 (22%)
		TGFB	300..400	CDD:214556	41/101 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810