DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF18A and Klp67A

DIOPT Version :9

Sequence 1:	NP_112494.3	Gene:	KIF18A / 81930	HGNCID:	29441	Length:	898	Species:	Homo sapiens
Sequence 2:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	763	Identity:	272/763 - (35%)
Similarity:	404/763 - (52%)	Gaps:	93/763 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    11 HMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVS-FFHGKKTTNQNVIKKQNKDLKF 74
            ::||.|||||.|.:|.......::.|:|:..|:|||.:|:.. ||.|.|...:::.|:.||.|..
  Fly     8 NIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLTM 72

Human    75 VFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLH 139
            .||.|||..::..::||..|.|::.:.||||||:|..|||||||||.|||||...||:.||||..
  Fly    73 EFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLTMQD 137

Human   140 LYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVREDTQKGVVVHGLTLHQPKSSEEIL 204
            |:..:....:.:.....|||||||||.:.:||..||||.:||| ..||||.||.|....|:||:|
  Fly   138 LFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPLKLRED-NNGVVVSGLCLTPIYSAEELL 201

Human   205 HLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKMSLIDLAGSERASTSG 269
            .:|..||.:|||||||.||.||||||:||:::|..::.....:.|   |:|:|||||||||:::.
  Fly   202 RMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTV---KLSMIDLAGSERAASTK 263

Human   270 AKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSP 334
            ..|.||.||.:||:|||||||.||.|||..:   |||||:|.|||:|||||||||:|:|:|.||.
  Fly   264 GIGVRFKEGASINKSLLALGNCINKLADGLK---HIPYRDSNLTRILKDSLGGNCRTLMVANVSM 325

Human   335 SSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKA 399
            ||:.|:|||||||||:|||.|:::||.|||........|||..:|..||...|||:.||.|   |
  Fly   326 SSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALE---A 387

Human   400 FTNENDQAKLMISNPQEKEIERFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQI 464
            ...:.::|.....:|  .|::.:...::.::....::::..|.:...:|...    |:|...|::
  Fly   388 KATQLERAGNSGFDP--LELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNIN----YRQTLKKEL 446

Human   465 E----MMCSEDKVEKATGKRDHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQN 525
            |    :||.:.:|.:...:|...  .:.|..|.:||.:|       |..:||.::|.....|..
  Fly   447 EEFRKLMCVDQRVCQEDFRRFAN--YMSTLTSQMEKYKE-------ELPSWLSKMEIAYQDLES- 501

Human   526 GHIPKELKKDLHCHHL--HLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNAL---LPTLRKQYC 585
              :.:|:.|......|  :::.|||:.|:..       |...:....|:...|   |..:||.:.
  Fly   502 --LKREVNKSKAYQILIVYVKYKDLELQLTK-------QNIFNNHVNAINQELVENLDLMRKSFR 557

Human   586 TLKEAGLSNAAF---ESDFK---EIEHLVER-KKVVVWADQTAEQPKQNDLPGISVLMTFPQLGP 643
            |..|  :.|..:   |...|   |||.:.|| .:.:.:||..| ..|..::..::|.:.......
  Fly   558 TACE--VLNQTYDRLEDGQKLTPEIEAVFERLLRKMRFADSEA-NTKMAEMNPLAVPVALRSSAQ 619

Human   644 VQPIPCCSSSGGTNLVKIPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKEL-----QPI 703
            .:..|.||.:..       .:||.|                   |:.|.:|.|...:     |..
  Fly   620 EEEEPTCSLTAS-------AKKRQR-------------------QAAQSDDDLHLSMEDFDSQDT 658

Human   704 VYTPEDCRKAFQNPSTVT---LMKPSSFTTSFQAISSNINSDNCLKML 748
            ....|:..:.|:.|..:.   ::.|.|.::|    ||..:|.:..|.|
  Fly   659 ESDSEELHRTFKRPRNLNETQVLGPCSSSSS----SSTSSSSSARKAL 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF18A	NP_112494.3	KISc_KIP3_like	11..355	CDD:276821	180/344 (52%)
		Kinesin	17..355	CDD:278646	177/338 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..690		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..871
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	183/351 (52%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	180/344 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	343	1.000	Domainoid score	I1064
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2136
Isobase	1	0.950	-	0	Normalized mean entropy	S2323
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D310221at33208
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		otm40683
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	1	1.000	-	-		X1854
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810