DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF18A and klp6

DIOPT Version :9

Sequence 1:	NP_112494.3	Gene:	KIF18A / 81930	HGNCID:	29441	Length:	898	Species:	Homo sapiens
Sequence 2:	NP_001342739.1	Gene:	klp6 / 2539700	PomBaseID:	SPBC1685.15c	Length:	784	Species:	Schizosaccharomyces pombe

Alignment Length:	939	Identity:	275/939 - (29%)
Similarity:	423/939 - (45%)	Gaps:	244/939 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    12 MKVVVRVRPENTKEKAA-----------------------------GFHKVVHVVDKHILVFDPK 47
            :.|.|||||...:||..                             |..|:|.|:|.::|:|||.
pombe     7 ISVAVRVRPFTEREKGLLAETPKSKEFLGDGSLAVSNTSSNTFCTNGIRKIVRVLDDNVLIFDPP 71

Human    48 QEEVSFFHGKKTTNQNVIKKQNK----------DLKFVFDAVFDETSTQSEVFEHTTKPILRSFL 102
            :|             |.:.|..|          |:::.||.:|.|.::|.:|::.||:|:|.|.|
pombe    72 EE-------------NPLAKVQKSLLPAGKRFRDVRYAFDRLFGEEASQEDVYKGTTEPLLDSVL 123

Human   103 NGYNCTVLAYGATGAGKTHTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQI 167
            .|||.||.||||||.|||||:.|..|:||:::|||..|...::.:|.......:|||||:|||:|
pombe   124 QGYNATVFAYGATGCGKTHTISGRPDDPGIIFLTMRALLDRVEGLKRTMNVDISVSYLEIYNEKI 188

Human   168 RDLLVNSGPLAVR--------EDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNAT 224
            |||||.. ||::.        ||.::.|.|.||:...|.:.||::.::..||.|||..||:.||.
pombe   189 RDLLVQD-PLSMEKPKSLNICEDAEQNVSVPGLSYFTPTNLEEVMEIIIRGNSNRTMSPTEANAV 252

Human   225 SSRSHAVFQIYLRQ-------QDKTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNIN 282
            |||||||.|||:.|       |:::.|.|.:...:..|.||||||||||.:..:|.|.|||.|||
pombe   253 SSRSHAVLQIYITQTPKSGEKQEESESQNSHKVRSVFSFIDLAGSERASATKNRGKRLVEGANIN 317

Human   283 RSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLK 347
            ||||||||.||:|.:.:|: ||:|||:||||||||.||||||:|.||..:||||..||:|:||||
pombe   318 RSLLALGNCINSLCEPRRR-QHVPYRDSKLTRLLKFSLGGNCRTCMIVCISPSSEHYDETHNTLK 381

Human   348 YANRAKDIKSSLKSNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMIS 412
            |.||||:||:.:..||::|:.|:::||:...|.:.::.:|         ||....|:.|..|
pombe   382 YGNRAKNIKTKVSRNVVSVDRHVSEYVRTIYELRQKVSIL---------QKRIAEESKQLAL--- 434

Human   413 NPQEKEIERFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKAT 477
               .||:.:        ..:||        ::||...:.||:.:.
pombe   435 ---NKEVRK--------ISSRE--------IKMLDARSMLKNSFD-------------------- 460

Human   478 GKRDHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHHLH 542
            |.||.:.:::                   |:...|.|:|.|:.|......|.|| ...:..|::
pombe   461 GSRDLQKSLI-------------------EHVRTLRRIEDEITLTKMWISIAKE-SDAMSGHNI- 504

Human   543 LQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESDFKEIEHL 607
               |.::.::..:.|       |.....|.:|.      ::.|         ..|::   .|.|:
pombe   505 ---KSVETRLAKLYD-------QRSLITAKVNP------EEIC---------KTFQN---SISHI 541

Human   608 VERKK---VVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVKIPTEKRTRR 669
            |...|   ..::||..     |:|:..:..::....|.........||              |.|
pombe   542 VSSFKGEGADMYADML-----QDDVDLLKSIIENQILDAKHESETFSS--------------TSR 587

Human   670 KLMPS-----PLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTVTLMKPSSFT 729
            ||:.:     ||.        |..::.:|:||::....:|...         ||..|:..|
pombe   588 KLIQNLFLLFPLL--------PGNAIDVNESLARAFDQLVGIV---------PSEPTIQVP---- 631

Human   730 TSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSK--CKLPEQESLPN- 791
                    |:.......:|....||.:..:...:....:...:.:.:|...  .::|...|:|.
pombe   632 --------NLIEKGKAPLLSMFEIPRSPSRFKARSPSKAARVLKKPLKKRVRFSEVPTTSSVPPV 688

Human   792 --DNKD----ILQRLDPSSFSTKHSMPVPS-----MVPSYMAMTTAAKRKRKLTSSTSNSSLTAD 845
              .|||    :.:.||..:.:...|..|||     .:.|....:..||.|...:|.....:|:..
pombe   689 EIKNKDSKPKVEKSLDKHNMNNDRSFLVPSRDARNSLTSLSLHSNVAKNKSSHSSKWPTHTLSPI 753

Human   846 VNSGFAKRVRQDNSSEKHLQ-----ENKP 869
            :.:...:.||:.:...:.||     ||.|
pombe   754 ITTALKQPVRRISLVSQPLQKTGGTENTP 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF18A	NP_112494.3	KISc_KIP3_like	11..355	CDD:276821	176/396 (44%)
		Kinesin	17..355	CDD:278646	174/391 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..690		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..871		10/45 (22%)
klp6	NP_001342739.1	KISc_KIP3_like	6..389	CDD:276821	176/396 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	344	1.000	Domainoid score	I214
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	382	1.000	Inparanoid score	I474
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		mtm10331
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	1	1.000	-	-		X1854
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850