DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AT2G46495 and RNF38

DIOPT Version :9

Sequence 1:	NP_850456.2	Gene:	AT2G46495 / 819259	AraportID:	AT2G46495	Length:	372	Species:	Arabidopsis thaliana
Sequence 2:	NP_073618.3	Gene:	RNF38 / 152006	HGNCID:	18052	Length:	515	Species:	Homo sapiens

Alignment Length:	137	Identity:	37/137 - (27%)
Similarity:	68/137 - (49%)	Gaps:	21/137 - (15%)

- Green bases have known domain annotations that are detailed below.

plant   237 PQVLKIILLSI-----IGPLTIFATCIAVGVCTSERFASLIQRNVAIAALQPNEVIVTTGLDESI 296
            |.:|..:|..:     :||...|...:..|  ..|.:.:|:.....:...:|.      ||.::.
Human   386 PSLLPYVLSMLPVPPAVGPTFSFELDVEDG--EVENYEALLNLAERLGEAKPR------GLTKAD 442

plant   297 IESYKKTELGESRRLPGN--NDDIVCPICLSEYASKETVRCIPECDHCFHSECIDVWLKIHGSCP 359
            ||     :|...|..|.|  ::..:|.:|:.::.|::.:|.:| |:|.||::|:|.|||.:.:||
Human   443 IE-----QLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLP-CNHEFHAKCVDKWLKANRTCP 501

plant   360 LCRNSPS 366
            :||...|
Human   502 ICRADAS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AT2G46495	NP_850456.2	GUB_WAK_bind	28..93	CDD:404778
		COG5219	<200..364	CDD:227544	36/133 (27%)
		RING-H2_EL5_like	319..362	CDD:319375	16/42 (38%)
RNF38	NP_073618.3	Bipartite nuclear localization signal 1	57..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..141
		Bipartite nuclear localization signal 2	115..131
		RING-H2_RNF38_like	460..504	CDD:319386	16/44 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	65	1.000	Domainoid score	I4385
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910