DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VANGL1 and Vangl1

DIOPT Version :9

Sequence 1:	NP_001165883.1	Gene:	VANGL1 / 81839	HGNCID:	15512	Length:	524	Species:	Homo sapiens
Sequence 2:	XP_006233116.1	Gene:	Vangl1 / 690366	RGDID:	1597324	Length:	539	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	501/539 - (92%)
Similarity:	515/539 - (95%)	Gaps:	15/539 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGNDS--TR 63
            |||||||||||||||||||||||||||||||||||||||||||||||||.|||||||.|||  |.
  Rat     1 MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQAPTGEPLLANDSAHTG 65

Human    64 TEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPI 128
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||
  Rat    66 TEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTIASFLGLLVFLTPI 130

Human   129 AFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLI 193
            ||||||.||||:||:|||.|||||.||::|||||||||||||||||:|||:||||||||||||||
  Rat   131 AFILLPQILWREELKPCGAICEGLLISVSFKLLILLIGTWALFFRKQRADVPRVFVFRALLLVLI 195

Human   194 FLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRST 258
            ||||||||||||||||||||:||:.||||||||||||||||||||||||||||||||||||||||
  Rat   196 FLFVVSYWLFYGVRILDSRDQNYKDIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRST 260

Human   259 DGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNV--------- 314
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 DGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDAALMAKLK 325

Human   315 ----DGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRL 375
                |||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
  Rat   326 LCVADGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRRARLVVAVEEAFIHIQRL 390

Human   376 QAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAF 440
            |||||||:|||||||||||||||||||||||||||.||||:|||||||||||||||||.||||||
  Rat   391 QAEEQQKSPGEVMDPREAAQAIFPSMARALQKYLRTTRQQHYHSMESILQHLAFCITNSMTPKAF 455

Human   441 LERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEE 505
            |||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||:||||
  Rat   456 LERYLSAGPTLQYDKDRWLSTQWRLISDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIVLSEE 520

Human   506 FIDPKSHKFVLRLQSETSV 524
            |||||||||||||||||||
  Rat   521 FIDPKSHKFVLRLQSETSV 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VANGL1	NP_001165883.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85		80/85 (94%)
VANGL1	NP_001165883.1	Strabismus	25..524	CDD:310915	475/513 (93%)
Vangl1	XP_006233116.1	Strabismus	25..539	CDD:399556	475/513 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83690212
Domainoid	1	1.000	941	1.000	Domainoid score	I1816
eggNOG	1	0.900	-	-		E1_KOG3814
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44540
Inparanoid	1	1.050	993	1.000	Inparanoid score	I5504
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47940
OrthoDB	1	1.010	-	-		D100323at40674
OrthoFinder	1	1.000	-	-		FOG0002892
OrthoInspector	1	1.000	-	-		oto139547
orthoMCL	1	0.900	-	-		OOG6_105860
Panther	1	1.100	-	-	LDO	PTHR20886
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.270