DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VANGL1 and vangl2

DIOPT Version :9

Sequence 1:	NP_001165883.1	Gene:	VANGL1 / 81839	HGNCID:	15512	Length:	524	Species:	Homo sapiens
Sequence 2:	NP_001027481.1	Gene:	vangl2 / 613073	XenbaseID:	XB-GENE-973460	Length:	521	Species:	Xenopus tropicalis

Alignment Length:	526	Identity:	382/526 - (72%)
Similarity:	447/526 - (84%)	Gaps:	7/526 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGNDSTRTE 65
            ||.:|.||||||.|.||:.|.:..:| ||||:| ::::|...:||||||.| |||||.|:|||.|
Frog     1 MDNDSQYSGYSYKSGHSRSSRKHRDR-RERHRS-KSREGSRGDKSVTIQAP-GEPLLDNESTRGE 62

Human    66 EVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAF 130
            : :|||||||||.:|||||||||.:||.||:||||||..|||.|:||:.:...|.||.|||||||
Frog    63 D-RDDNWGETTTVVTGTSEHSISHDDITRITKDMEDSAKLDCSRHLGVVIGGALALLSFLTPIAF 126

Human   131 ILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFL 195
            :|||.||||::||.|||.|||||||:||||||||:|:||||||:.:|..||||||||||:||:||
Frog   127 MLLPQILWREDLEQCGTACEGLFISVAFKLLILLLGSWALFFRRPKAFFPRVFVFRALLMVLVFL 191

Human   196 FVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDG 260
            .|||||||||||||:|||:||||||||||||||||||:||||:||||||||||.||::|||||||
Frog   192 LVVSYWLFYGVRILESRDKNYQGIVQYAVSLVDALLFVHYLAVVLLELRQLQPQFTVKVVRSTDG 256

Human   261 ESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNV--DGPSNNATG 323
            .||||::|||||||.|:.:|||||.||.:|||.||...|...:|.|:|.|||::  :..:||:||
Frog   257 ASRFYNIGHLSIQRVAVWILENYYHDFPVYNPALLNLPKSILSKKMSGFKVYSLGEENTTNNSTG 321

Human   324 QSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVM 388
            ||||:|||||||||:||||.|||||||||||:||||||||||||||.||:||| :|.||.|.|:|
Frog   322 QSRAVIAAAARRRDNSHNEYYYEEAEHERRVRKRKARLVVAVEEAFTHIKRLQ-DEDQKNPREIM 385

Human   389 DPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQY 453
            ||||||||||.|||||:|||||.|:||.||:|||||.||.||||:.|||||||||||..|||:||
Frog   386 DPREAAQAIFASMARAMQKYLRTTKQQPYHTMESILHHLEFCITHDMTPKAFLERYLGPGPTIQY 450

Human   454 DKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRL 518
            .|||||:.||.|||:|.|||||:||:|||||..||||||:.|||||..|||||:||||||||:||
Frog   451 HKDRWLAKQWTLVSEEPVTNGLKDGVVFVLKRQDFSLVVSTKKIPFFKLSEEFVDPKSHKFVMRL 515

Human   519 QSETSV 524
            ||||||
Frog   516 QSETSV 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VANGL1	NP_001165883.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85		50/83 (60%)
VANGL1	NP_001165883.1	Strabismus	25..524	CDD:310915	367/500 (73%)
vangl2	NP_001027481.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		50/83 (60%)
		Strabismus	24..521	CDD:369014	367/501 (73%)
		PDZ-binding. /evidence=ECO:0000255	518..521		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47940
OrthoDB	1	1.010	-	-		D1325060at2759
OrthoFinder	1	1.000	-	-		FOG0002892
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4213
SonicParanoid	1	1.000	-	-		X2248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960