DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VANGL1 and vangl1

DIOPT Version :9

Sequence 1:	NP_001165883.1	Gene:	VANGL1 / 81839	HGNCID:	15512	Length:	524	Species:	Homo sapiens
Sequence 2:	NP_991313.1	Gene:	vangl1 / 403076	ZFINID:	ZDB-GENE-040621-2	Length:	527	Species:	Danio rerio

Alignment Length:	528	Identity:	346/528 - (65%)
Similarity:	428/528 - (81%)	Gaps:	5/528 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDTESTYSGYSYYSSHSKKSHRQGER-TRERHKSPRNKDGRG-SEKSVTIQPPTGEPLLGNDSTR 63
            |||:|.:||||::|:.|:.|::|.|| :|:||| |.::|... |:|:|||...:.:|...:.|:.
Zfish     1 MDTDSIHSGYSHHSNRSRGSNKQSERSSRDRHK-PHSRDSSSRSDKNVTISATSVQPQQPDQSSA 64

Human    64 TEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSV-GLDCKRYLGLTVASFLGLLVFLTP 127
            ..:.|||||||||||:||||:||:||||:|...||.|..| .|:|.|:|.|.:...|||||.:||
Zfish    65 PTDAQDDNWGETTTAVTGTSDHSLSQEDLAGFGKDTEGPVEKLNCIRFLPLALTLLLGLLVLVTP 129

Human   128 IAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVL 192
            ::|::||.::|.:.|:.|||.|||||:|:||||||||:..||||.|..||.:|.:.||||||.:|
Zfish   130 LSFLILPQLMWPERLQTCGTACEGLFLSLAFKLLILLLAGWALFMRPTRASLPGIAVFRALLGLL 194

Human   193 IFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRS 257
            ..|.::|||||:|||||||:|.|||||||:|||||||||||||||:||||:|.|||.|:|.||||
Zfish   195 TLLLLLSYWLFFGVRILDSQDDNYQGIVQFAVSLVDALLFIHYLAVVLLEIRHLQPCFSLCVVRS 259

Human   258 TDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGP-SNNA 321
            ||||:..|::|.|||||||||.||:||||||::||.||||:|.|||||:||||||||||. |:.|
Zfish   260 TDGETHHYNMGQLSIQRAALVTLEHYYKDFTVHNPALLTAAKSRAAKHLAGLKVYNVDGAGSDAA 324

Human   322 TGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGE 386
            |.||||.:|||||:||:||||||||||||:|||:||||||||||||||.|::|||.||::|.||:
Zfish   325 TAQSRAKMAAAARQRDTSHNELYYEEAEHDRRVRKRKARLVVAVEEAFTHVRRLQDEEKKKPPGD 389

Human   387 VMDPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTL 451
            .|||||||||||||||||||||||.||||:.|||:||..||||||||.||||||||.||:|||||
Zfish   390 EMDPREAAQAIFPSMARALQKYLRTTRQQHCHSMDSIQAHLAFCITNNMTPKAFLESYLTAGPTL 454

Human   452 QYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVL 516
            ||.::...:..|.|||:.:||:.||:|..|.||..||||||..|.||.:.||||::.||||||||
Zfish   455 QYGRESSQTRHWTLVSEASVTSPLRNGSEFQLKSSDFSLVVTSKTIPHLKLSEEYVHPKSHKFVL 519

Human   517 RLQSETSV 524
            :|||||||
Zfish   520 QLQSETSV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VANGL1	NP_001165883.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85		42/85 (49%)
VANGL1	NP_001165883.1	Strabismus	25..524	CDD:310915	332/502 (66%)
vangl1	NP_991313.1	Strabismus	27..527	CDD:284135	330/500 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194337490
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3814
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44540
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47940
OrthoDB	1	1.010	-	-		D1325060at2759
OrthoFinder	1	1.000	-	-		FOG0002892
OrthoInspector	1	1.000	-	-		oto42424
orthoMCL	1	0.900	-	-		OOG6_105860
Panther	1	1.100	-	-	LDO	PTHR20886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4213
SonicParanoid	1	1.000	-	-		X2248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	15	15.250