DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VANGL1 and Vang

DIOPT Version :9

Sequence 1:	NP_001165883.1	Gene:	VANGL1 / 81839	HGNCID:	15512	Length:	524	Species:	Homo sapiens
Sequence 2:	NP_001260819.1	Gene:	Vang / 35922	FlyBaseID:	FBgn0015838	Length:	608	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	257/587 - (43%)
Similarity:	359/587 - (61%)	Gaps:	69/587 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDTESTYSGYSYYSSHSKKS----------------------HRQGERTRERHKSPR-NKDGRGS 42
            |:.||..|.:|..|..|:..                      ||:.:|:|..|:|.. :|..:|.
  Fly     1 MENESVKSEHSGRSRRSRNHNNNGGGGGGGGGGGGGSVNNGYHRERDRSRHSHRSTHSSKSAKGF 65

Human    43 EKSVTIQPPTGEPLLGNDSTRTEEV-------QDDNWGETTTAITG-TSEHSISQEDIARI-SKD 98
            ::.......|...:.|:.|...:||       ||:||||.|||:|| |||.|||.|||..: .::
  Fly    66 QRGDMAPYQTSVNMTGDGSHDGQEVIEVQILPQDENWGENTTAVTGNTSEQSISMEDINNMWHRE 130

Human    99 MEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILW--------------RDELEPCGTIC 149
            .:......|:||:..:....||...|.:|:|.:::|.:.:              |.:|..|...|
  Fly   131 SDKGFSFACRRYVESSFYFLLGCGAFFSPVAMVVMPYVGFFPSAFDHPEITQTVRTQLLACSEQC 195

Human   150 EGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFY------GVRI 208
            :|..:|:|.:||:|.||.||:|.|:..|.|||:|::|||:|:|:.:...:|||||      |.:|
  Fly   196 KGQLVSLAARLLLLAIGLWAVFMRRTSATMPRIFLYRALVLLLVTICTFAYWLFYIVQVTNGAKI 260

Human   209 L-----DSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLG 268
            :     |:.|  |:.:|.||.:.||.||||||:|:||||||..||.:.::::||.||.||.|.||
  Fly   261 VVETGGDAVD--YKSLVGYATNFVDTLLFIHYVAVVLLELRHQQPCYYIKIIRSPDGVSRSYMLG 323

Human   269 HLSIQRAALVVLENYYKDFTIYNPNL----LTASKFRAAKHMAGLKVYNVDGPSNN-ATGQSRAM 328
            .|||||||:.||::||.||.|:||.|    ::.||.:..|.....|.|.|||.||: ...||||:
  Fly   324 QLSIQRAAVWVLQHYYVDFPIFNPYLERIPISVSKSQRNKISNSFKYYEVDGVSNSQQQSQSRAV 388

Human   329 IAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREA 393
            :||.||||||||||.:|||.|:|||||||:|||:.|.||||.||:|:..|   .||...:||:||
  Fly   389 LAANARRRDSSHNERFYEEHEYERRVKKRRARLITAAEEAFTHIKRIHNE---PAPALPLDPQEA 450

Human   394 AQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKD-R 457
            |.|:|||||||||||||:||||..|:.||||:|||.|:.:.::|:||||.||:..|.:|.:|: |
  Fly   451 ASAVFPSMARALQKYLRVTRQQPRHTFESILKHLAHCLKHDLSPRAFLEPYLTESPVMQSEKERR 515

Human   458 WLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSET 522
            |:.: |.|:.||.|:..:.:...|.|...|.||:|.|.|:|...|:||.:||||:||||:|.|||
  Fly   516 WVQS-WSLICDEIVSRPIGNECTFQLIQNDVSLMVTVHKLPHFNLAEEVVDPKSNKFVLKLNSET 579

Human   523 SV 524
            ||
  Fly   580 SV 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VANGL1	NP_001165883.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85		33/114 (29%)
VANGL1	NP_001165883.1	Strabismus	25..524	CDD:310915	246/539 (46%)
Vang	NP_001260819.1	Strabismus	44..581	CDD:284135	247/542 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156760
Domainoid	1	1.000	433	1.000	Domainoid score	I586
eggNOG	1	0.900	-	-		E1_KOG3814
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44540
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1687
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47940
OrthoDB	1	1.010	-	-		D1325060at2759
OrthoFinder	1	1.000	-	-		FOG0002892
OrthoInspector	1	1.000	-	-		otm41595
orthoMCL	1	0.900	-	-		OOG6_105860
Panther	1	1.100	-	-	O	PTHR20886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4213
SonicParanoid	1	1.000	-	-		X2248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800