Protein Alignment VANGL1 and Vangl1

DIOPT Version :9

• Sequence 1: NP_001165883.1
• Gene: VANGL1 / 81839
• HGNCID: 15512
• Length: 524
• Species: Homo sapiens
• Sequence 2: XP_006501458.1
• Gene: Vangl1 / 229658
• MGIID: 2159344
• Length: 539
• Species: Mus musculus
• Alignment Length: 539
• Identity: 500/539 - (92%)
• Similarity: 514/539 - (95%)
• Gaps: 15/539 - (2%)

Human     1 MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGNDSTRT- 64
            |||||||||||||||||||||||||||||||||||||||||||||||||.|.|||||.|||.||
Mouse     1 MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQAPAGEPLLANDSARTG 65

Human    65 -EEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPI 128
             ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 AEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPI 130

Human   129 AFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLI 193
            ||||||.||||:||:|||.|||||.||::|||||||||||||||||:|||:||||||||||||||
Mouse   131 AFILLPQILWREELKPCGAICEGLLISVSFKLLILLIGTWALFFRKQRADVPRVFVFRALLLVLI 195

Human   194 FLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRST 258
            ||||||||||||||||||||:||:.||||||||||||||||||||||||||||||||||||||||
Mouse   196 FLFVVSYWLFYGVRILDSRDQNYKDIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRST 260

Human   259 DGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNV--------- 314
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 DGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDAALMAKLK 325

Human   315 ----DGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRL 375
                |||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
Mouse   326 LCVADGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRRARLVVAVEEAFIHIQRL 390

Human   376 QAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAF 440
            |||||||:|||||||||||||||||||||||||||.||||:|||||||||||||||||.||||||
Mouse   391 QAEEQQKSPGEVMDPREAAQAIFPSMARALQKYLRTTRQQHYHSMESILQHLAFCITNSMTPKAF 455

Human   441 LERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEE 505
            |||||||||||||||||||||||||:|:||||||||||||||||||||||||||||||||:||||
Mouse   456 LERYLSAGPTLQYDKDRWLSTQWRLISEEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIVLSEE 520

Human   506 FIDPKSHKFVLRLQSETSV 524
            |||||||||||||||||||
Mouse   521 FIDPKSHKFVLRLQSETSV 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VANGL1	NP_001165883.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..85		79/85 (93%)
		Strabismus	25..524	CDD:310915	474/513 (92%)
Vangl1	XP_006501458.1	Strabismus	25..539	CDD:369014	474/513 (92%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83966756
Domainoid	1	1.000	938	1.000	Domainoid score	I1973
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44540
Inparanoid	1	1.050	990	1.000	Inparanoid score	I5890
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47940
OrthoDB	1	1.010	-	-		D100323at40674
OrthoFinder	1	1.000	-	-		FOG0002892
OrthoInspector	1	1.000	-	-		oto123378
orthoMCL	1	0.900	-	-		OOG6_105860
Panther	1	1.100	-	-	LDO	PTHR20886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4213
SonicParanoid	1	1.000	-	-		X2248
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	16.440