DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VANGL1 and vang-1

DIOPT Version :9

Sequence 1:	NP_001165883.1	Gene:	VANGL1 / 81839	HGNCID:	15512	Length:	524	Species:	Homo sapiens
Sequence 2:	NP_508500.1	Gene:	vang-1 / 180579	WormBaseID:	WBGene00015171	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	185/556 - (33%)
Similarity:	281/556 - (50%)	Gaps:	68/556 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     2 DTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGNDSTRTEE 66
            ||.|...|:. |..|.|       :.|.|:                .|...|||.:...|....|
Worm    12 DTRSCVGGFR-YEGHKK-------QLRPRY----------------AQSEIGEPFIPRFSAIASE 52

Human    67 VQ-----DDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLT 126
            .|     :::|.:.||.:||.:..|.:.|:....:..:...:|..|.|::.|..:|.|.::..::
Worm    53 GQKIAPPNEDWADNTTVLTGMTTDSFTMEEKVIYTPPIGRVIGRRCSRFVWLLASSLLCIISVVS 117

Human   127 PIAFILLPPILWRDELE----PCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRA 187
            ......||.|..|....    .|...||||...||.|.:.|:|....|::||..|||||::..||
Worm   118 APIMCSLPIIAPRFGFSMPAIQCDVDCEGLLFLMAIKTIFLVIAIGVLYWRKAMADMPRLYFVRA 182

Human   188 LLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTL 252
            .|..|:...:.::||||.|||:..|..||:.||.|:.||:||||:.|||::||||||:|:..|.:
Worm   183 ALTFLVMFILFAFWLFYIVRIMFERYDNYKYIVSYSTSLLDALLWTHYLSVVLLELRRLRAQFIV 247

Human   253 QVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKH------MAGLKV 311
            .:||..|||....::|..|||.||..:|..|...|:.:|.:|..|.:...||.      .||.|:
Worm   248 TIVRDPDGEMHTLNIGAGSIQEAATEILRFYTTRFSSFNIHLDNARQTAVAKQSGMQGGTAGFKM 312

Human   312 YNVD---GPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQ 373
            ||::   |....:...:||::.||||||...:.|:..||.:.|:|:||||.||:.|.|:||.|:|
Worm   313 YNIEQFGGQETVSEVNTRALMEAAARRRIGGYAEVMQEELDFEKRLKKRKYRLIAAAEDAFSHVQ 377

Human   374 RLQAEEQQKAPG--EVMDPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMT 436
            ........:.||  ..||...|||.:|..:.|.|.|||:.||.|:.|....:.:|:..|:|..::
Worm   378 NTAESGTNQKPGINNQMDSLTAAQNVFTWIVRPLTKYLKTTRLQSRHPSGEVTRHIERCLTLKLS 442

Human   437 PKAFLERYLSAGPTLQYDKDRWL------STQWRLVSDEAVTNGLRDGIVFVLK-------CLDF 488
            .:.||:|:.|         ||..      .::|.::.||||::|::.|...|||       | ..
Worm   443 HRTFLQRFFS---------DRIPQREIVGESKWSVICDEAVSSGVQHGTYLVLKSHNPDIDC-GV 497

Human   489 SLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV 524
            .||..:..|||..|:|: ..|.:.||.|::.:|::|
Worm   498 QLVCTISSIPFFNLTEQ-AKPGNEKFSLKISNESAV 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VANGL1	NP_001165883.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..85		21/87 (24%)
VANGL1	NP_001165883.1	Strabismus	25..524	CDD:310915	177/531 (33%)
vang-1	NP_508500.1	Strabismus	44..532	CDD:284135	171/498 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161464808
Domainoid	1	1.000	270	1.000	Domainoid score	I1090
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44540
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2074
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47940
OrthoDB	1	1.010	-	-		D1325060at2759
OrthoFinder	1	1.000	-	-		FOG0002892
OrthoInspector	1	1.000	-	-		otm15360
orthoMCL	1	0.900	-	-		OOG6_105860
Panther	1	1.100	-	-	O	PTHR20886
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4213
SonicParanoid	1	1.000	-	-		X2248
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940