DRSC/TRiP Functional Genomics Resources

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Protein Alignment CAMK2G and RCK2

DIOPT Version :10

Sequence 1:NP_001307827.1 Gene:CAMK2G / 818 HGNCID:1463 Length:592 Species:Homo sapiens
Sequence 2:NP_013349.1 Gene:RCK2 / 850950 SGDID:S000004238 Length:610 Species:Saccharomyces cerevisiae


Alignment Length:397 Identity:121/397 - (30%)
Similarity:186/397 - (46%) Gaps:93/397 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    14 YQLFEELGKGAFSVVRRCV-KKTSTQEY--------AAKIINTKKLSA--RDHQKLEREARICRL 67
            |:|..::|:||||.|.|.: .|.|:.|:        |.|:|....||:  .||:|.::.....:.
Yeast   163 YKLINKIGEGAFSKVFRAIPAKNSSNEFLTKNYKAVAIKVIKKADLSSINGDHRKKDKGKDSTKT 227

Human    68 LKHPNI---VRLHDSIS--------------EEGFHYLVFDLVTGGELFEDIVAREYYSEADASH 115
            .....:   |.||.::|              .:.::|::.:|:||||:|.:||...|:||..:.|
Yeast   228 SSRDQVLKEVALHKTVSAGCSQIVAFIDFQETDSYYYIIQELLTGGEIFGEIVRLTYFSEDLSRH 292

Human   116 CIHQILESVNHIHQHDIVHRDLKPENLL---------LASKCKGA-------------------- 151
            .|.|:..:|.|:|...:||||:||||||         :..|.:.:                    
Yeast   293 VIKQLALAVKHMHSLGVVHRDIKPENLLFEPIEFTRSIKPKLRKSDDPQTKADEGIFTPGVGGGG 357

Human   152 --AVKLADFGLAIEVQGEQQAWFGFA-------GTPGYLSPEVLRKDPYGKPVDIWACGVILYIL 207
              .||||||||:.::         |:       ||.||.:|||::.:.|...||:|..|.:||.:
Yeast   358 IGIVKLADFGLSKQI---------FSKNTKTPCGTVGYTAPEVVKDEHYSMKVDMWGIGCVLYTM 413

Human   208 LVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV 272
            |.|:|||:||....|.::|..|.|.|..|.||.::..|||.:.::|.:.|:||...||.|..||:
Yeast   414 LCGFPPFYDEKIDTLTEKISRGEYTFLKPWWDEISAGAKNAVAKLLELEPSKRYDIDQFLDDPWL 478

Human   273 CQRSTVASMMHRQETVECL-RKFNARRKLKGAILTTMLVSRNFSV-GRQSSAPASPAASAAGLA- 334
                         .|.:|| ::..:.:|..|.........:.|.: .|.||...||||.|...| 
Yeast   479 -------------NTFDCLPKEGESSQKKAGTSERRHPHKKQFQLFQRDSSLLFSPAAVAMRDAF 530

Human   335 --GQAAK 339
              |.|.|
Yeast   531 DIGNAVK 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CAMK2GNP_001307827.1 STKc_CaMKII 12..303 CDD:270988 107/355 (30%)
NTF2_like 433..>488 CDD:471850
RCK2NP_013349.1 STKc_RCK1-like 161..478 CDD:270998 102/323 (32%)
Blue background indicates that the domain is not in the aligned region.

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