Protein Alignment CAMK2G and CaMKII

DIOPT Version :10

• Sequence 1: NP_001307827.1
• Gene: CAMK2G / 818
• HGNCID: 1463
• Length: 592
• Species: Homo sapiens
• Sequence 2: NP_001162833.1
• Gene: CaMKII / 43828
• FlyBaseID: FBgn0264607
• Length: 531
• Species: Drosophila melanogaster
• Alignment Length: 504
• Identity: 335/504 - (66%)
• Similarity: 383/504 - (75%)
• Gaps: 75/504 - (14%)

Human     1 MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARIC 65
            ||..|.||||:|:|.:.|||||||||:|:|||:|::..|:||||||||||:|||.||||||||||
  Fly     1 MAAPAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARIC 65

Human    66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 130
            |.|.|||||||||||.||.:|||||||||||||||||||||:||||||||||.||||||||.||:
  Fly    66 RKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQN 130

Human   131 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPV 195
            .:|||||||||||||||.||||||||||||||||||:.||||||||||||||||||:|:||||.|
  Fly   131 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSV 195

Human   196 DIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKR 260
            |||||||||||||||||||||||||:||.||||||||:|||||||||||||||||||||:||.||
  Fly   196 DIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKR 260

Human   261 ITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPAS 325
            |||.:||||||:|||..|||::||||||:||:|||||||||||||||||.:||||
  Fly   261 ITAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFS---------- 315

Human   326 PAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDE 390
                        ::|::.||.:|                         ..:|.||:|.:||.||:
  Fly   316 ------------SRSMITKKGEG-------------------------SQVKESTDSSSTTLEDD 343

Human   391 DLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQP----------------SLCSSAMRKQEIIK 439
            |:|            .:.:.:.||:......:|:.                |.||||.|:|||||
  Fly   344 DIK------------EDKKGTVDRSTTVVSKEPEDIRILCPAKTYQQNIGNSQCSSAARRQEIIK 396

Human   440 ITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFEN 488
            ||||||||||:|||:.|||||||.||:||||||||||||:|||||||||
  Fly   397 ITEQLIEAINSGDFDGYTKICDPHLTAFEPEALGNLVEGIDFHKFYFEN 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2G	NP_001307827.1	STKc_CaMKII	12..303	CDD:270988	245/290 (84%)
		NTF2_like	433..>488	CDD:471850	47/54 (87%)
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	245/290 (84%)
		CaMKII_AD	390..517	CDD:285524	49/56 (88%)