Protein Alignment CAMK2G and unc-43

DIOPT Version :10

• Sequence 1: NP_001307827.1
• Gene: CAMK2G / 818
• HGNCID: 1463
• Length: 592
• Species: Homo sapiens
• Sequence 2: NP_001255480.1
• Gene: unc-43 / 177921
• WormBaseID: WBGene00006779
• Length: 681
• Species: Caenorhabditis elegans
• Alignment Length: 522
• Identity: 313/522 - (59%)
• Similarity: 370/522 - (70%)
• Gaps: 56/522 - (10%)

Human     1 MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARIC 65
            :|.....|:|:|:|.:.|||||||||||||||.||:..|:||||||||||||||.||||||||||
 Worm   109 LAMMNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARIC 173

Human    66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQH 130
            |.|:|||||||||||.||.||||||||||||||||||||||:||||||||||.|||||:.:.|.:
 Worm   174 RKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSN 238

Human   131 DIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPV 195
            .||||||||||||||||.|||||||||||||||| .:.:||.||||||||||||||:||||.|||
 Worm   239 GIVHRDLKPENLLLASKAKGAAVKLADFGLAIEV-NDSEAWHGFAGTPGYLSPEVLKKDPYSKPV 302

Human   196 DIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKR 260
            |||||||||||||||||||||||||:||.||||||||:|||||||||||||:||:.|||:||.||
 Worm   303 DIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKR 367

Human   261 ITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGR------- 318
            ||||||||.||:|.|..|||.:|||:||:||:|||||||||.||....:|:|...|.|
 Worm   368 ITADQALKVPWICNRERVASAIHRQDTVDCLKKFNARRKLKAAISAVKMVTRMSGVLRTSDSTGS 432

Human   319 ----------------QSSAPASPAASAAGLAGQAA--------KSLLNKKSDGGVKKRKSSSSV 359
                            .||.|.||||..|.|....|        ::|||||..|.....|.||
 Worm   433 VASNGSTTHDASQVAGTSSQPTSPAAEGAILTTMIATRNLSNLGRNLLNKKEQGPPSTIKESS-- 495

Human   360 HLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQ 424
               |...|:..|.::...|..:..||....:.  |..:.:.:.||.....||.:.:|
 Worm   496 ---ESSQTIDDNDSEKGGGQLKHENTVVRADG--ATGIVSSSNSSTASKSSSTNLSA-------- 547

Human   425 PSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFE-N 488
                    :||:|:::|:.|::||:..|||.||::||..:|.|||||||||:||::||:|||: |
 Worm   548 --------QKQDIVRVTQTLLDAISCKDFETYTRLCDTSMTCFEPEALGNLIEGIEFHRFYFDGN 604

Human   489 RE 490
            |:
 Worm   605 RK 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2G	NP_001307827.1	STKc_CaMKII	12..303	CDD:270988	240/290 (83%)
		NTF2_like	433..>488	CDD:471850	31/55 (56%)
unc-43	NP_001255480.1	STKc_CaMKII	120..410	CDD:270988	240/290 (83%)
		CaMKII_AD	548..672	CDD:285524	33/59 (56%)