Protein Alignment NUAK2 and KKQ8

DIOPT Version :10

• Sequence 1: NP_112214.3
• Gene: NUAK2 / 81788
• HGNCID: 29558
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_012753.2
• Gene: KKQ8 / 853686
• SGDID: S000001651
• Length: 724
• Species: Saccharomyces cerevisiae
• Alignment Length: 309
• Identity: 81/309 - (26%)
• Similarity: 131/309 - (42%)
• Gaps: 81/309 - (26%)

Human     7 ARRSGPT-----------PSAA------ELARPLAEGLIKSPKPLMKKQAVKRHH--------HK 46
            :.||.||           |.|:      :|...|:..:.||.:..::::.:|...        .:
Yeast   344 SNRSSPTQGREDYLKIVNPDASLGSDELKLINSLSSRIHKSLQNYLQEKNLKPAECIGEQAPTFQ 408

Human    47 HNLRHRYEFLETLGKGTYGKVKKA---------------RESSGRLVAIKSIRKDKIKDEQDL-- 94
            .|..|.   :..:|.|.||:||..               .:|.....|:|.:   |.|.:.||
Yeast   409 DNYGHP---VGLVGAGAYGEVKLCARLRNEKDSPPFETYHDSKYIYYAVKEL---KPKPDSDLEK 467

Human    95 --MHIRREIEIMSSLNH---------PHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLS 148
              ..|..|..|..||:|         |:|:.:.::.|:||..:.|||:...||||..:..:.:|.
Yeast   468 FCTKITSEFIIGHSLSHYHKNGKKPAPNILNVFDILEDSSSFIEVMEFCPAGDLYGMLVGKSKLK 532

Human   149 ER----EARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTF 209
            .|    ||..|.:|::..|.:.|.:.:.|.|||.||||...:|.:||.|||.|:::      ||.
Yeast   533 GRLHPLEADCFMKQLLHGVKFMHDHGIAHCDLKPENILFYPHGLLKICDFGTSSVF------QTA 591

Human   210 CGSPLYASPEIVNGKPYTGPE------------VDSWSLGVLLYILVHG 246
            ....::|...|:..:||..||            :|.||.||:...::.|
Yeast   592 WERRVHAQKGIIGSEPYVAPEEFVDGEYYDPRLIDCWSCGVVYITMILG 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUAK2	NP_112214.3	STKc_NUAK2	49..303	CDD:271063	69/242 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..493
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..562
KKQ8	NP_012753.2	Protein Kinases, catalytic domain	418..712	CDD:473864	68/232 (29%)