Protein Alignment NUAK2 and KCC4

DIOPT Version :10

• Sequence 1: NP_112214.3
• Gene: NUAK2 / 81788
• HGNCID: 29558
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_009907.2
• Gene: KCC4 / 850334
• SGDID: S000000529
• Length: 1037
• Species: Saccharomyces cerevisiae
• Alignment Length: 582
• Identity: 174/582 - (29%)
• Similarity: 271/582 - (46%)
• Gaps: 117/582 - (20%)

Human    57 ETLGKGTYGKVKKAR-ESSGRLVAIKSIRK-------DKIKDEQDL-MHIRREIEIMSSLNHPHI 112
            ||||.|:.|||:.|: |.:|...|:|.|.|       :...|:..| .:|.|||.||..|:||::
Yeast    25 ETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLSHPNV 89

Human   113 IAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLK 177
            :::::|:|.::.:.:::|||.:|:|::.:.:...|.||||.:.||||:..:.|||...:||||||
Yeast    90 LSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLK 154

Human   178 LENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYI 242
            .||:|||:..||||||||::.|......|:|.||||.||:||||:|.||.|...|.||.||:|:.
Yeast   155 PENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFA 219

Human   243 LVHGTMPFD---GHDHKILVKQISNGAYREPPKPS---DACGLIRWLLMVNPTRRATLEDVASHW 301
            |:.|.:|||   |:...:|:| :..|.:..|....   ||..||..:|:|:|.:|..:.|:.||.
Yeast   220 LLTGRLPFDEENGNVRDLLLK-VQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHP 283

Human   302 WVNWGYAT---RVGEQEAPHEGG--HPGSDS---ARASMAD---------WLRRSS----RPLLE 345
            .:. .|.|   ....::.|.|..  :|.:||   ..||:.|         |..|.:    ..|.|
Yeast   284 LLK-KYQTIKDSKSIKDLPRENTYLYPLADSNNHTSASIDDSILQNLVVLWHGRHADDIVSKLKE 347

Human   346 NGAK-------VCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSN 403
            ||..       :...||..:..|.:.    :.::.:||::| |..:.:|.|.::....:|..:|.
Yeast   348 NGTNKEKILYALLYRFKLDSVRGSNK----KNRNKIKKTKK-NKRSSTLSSSSSLLLNNRSIQST 407

Human   404 LKLPKGILKKKVS--------ASAEGVQEDPPELSPIP-------------ASPGQAAPL---LP 444
               |:....|:.|        .|:..:..:|.:.||||             ::..||.|.   .|
Yeast   408 ---PRRRTSKRHSREFSSSRKRSSFLLSSNPTDSSPIPLRSSKRITHINVASANTQATPSGVPNP 469

Human   445 KKGILKKPRQRESGY--------YSSPEPSESGELLDAGD-VFVSGDPKEQKPPQASGLLLHRKG 500
            .|...||...:...|        .:|...|....|:|..| .::..|.|
Yeast   470 HKRNSKKRSSKRLSYMPNTKRSSLTSKSLSNFTNLIDDDDWEYIEKDAK---------------- 518

Human   501 ILKLNGKFSQTALELAAPTTFGSLDELAP------PRPLARASRPS---GAVSEDSILSSES 553
              :.:..|:....|:..|..|    |||.      .|.:..|.|.|   ..::||...|..|
Yeast   519 --RTSSNFATLIDEIFEPEKF----ELAKREKAELQRKVQEAKRQSVNAQKINEDEFGSEVS 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUAK2	NP_112214.3	STKc_NUAK2	49..303	CDD:271063	108/260 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..493		34/170 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..562		8/26 (31%)
KCC4	NP_009907.2	Protein Kinases, catalytic domain	19..285	CDD:473864	108/260 (42%)
		Kcc4p_like_C	920..1034	CDD:213379