Protein Alignment NUAK2 and Nuak2

DIOPT Version :10

• Sequence 1: NP_112214.3
• Gene: NUAK2 / 81788
• HGNCID: 29558
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_001181954.1
• Gene: Nuak2 / 74137
• MGIID: 1921387
• Length: 639
• Species: Mus musculus
• Alignment Length: 643
• Identity: 544/643 - (84%)
• Similarity: 570/643 - (88%)
• Gaps: 19/643 - (2%)

Human     1 MESLVFARRSGPTPS----AAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGK 61
            |||:...:|....||    |:|.|||||:||||||||||||||||||||||||||||||||||||
Mouse     1 MESVALLQRPSQAPSASALASESARPLADGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGK 65

Human    62 GTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHE--------V 118
            |||||||||||||||||||||||||||||||||:||||||||||||||||||||||        |
Mouse    66 GTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIHEVGRSRLVTV 130

Human   119 FENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILL 183
            ||||||||||||||||||||||||||.:||||:|||||||||||:||||||.:||||||||||||
Mouse   131 FENSSKIVIVMEYASRGDLYDYISERPRLSERDARHFFRQIVSALHYCHQNGIVHRDLKLENILL 195

Human   184 DANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTM 248
            ||||||||||||||||||:||||||||||||||||||||||||.|||||||||||||||||||||
Mouse   196 DANGNIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGVLLYILVHGTM 260

Human   249 PFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGE 313
            ||||.|||.||||||||||||||||||||||||||||||||||||||||||||||||||.|.|||
Mouse   261 PFDGQDHKTLVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYTTGVGE 325

Human   314 QEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSR 378
            |||..|||||..|..|||||||||||||||||||||||||||||.||||||.|||||||||||||
Mouse   326 QEALREGGHPSGDFGRASMADWLRRSSRPLLENGAKVCSFFKQHVPGGGSTVPGLERQHSLKKSR 390

Human   379 KENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAEGVQEDPPELSPIPASPGQAAP-- 441
            |||||||:|..|.|:||:.|||||:|||||||||||.|.|:..|||||.||.|:|.:|||..|
Mouse   391 KENDMAQNLQGDPAEDTSSRPGKSSLKLPKGILKKKSSTSSGEVQEDPQELRPVPDTPGQPVPAV 455

Human   442 -LLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKEQKPPQASGLLLHRKGILKLN 505
             |||:||||||.||||||||||||||||||||||.||||||||.|||.|||||||||||||||||
Mouse   456 SLLPRKGILKKSRQRESGYYSSPEPSESGELLDASDVFVSGDPVEQKSPQASGLLLHRKGILKLN 520

Human   506 GKFSQTALELAAPTTFGSLDELAPPRPLARASRPSGAVSEDSILSSESFDQLDLPERLPEPPLRG 570
            ||||:||||...|:||||||:||...|.||.|||||||||||||||||||||||||||||.||||
Mouse   521 GKFSRTALEGTTPSTFGSLDQLASSHPAARPSRPSGAVSEDSILSSESFDQLDLPERLPETPLRG 585

Human   571 CVSVDNLTGLEEPPSEGPGSCLRRWRQDPLGDSCFSLTDCQEVTATYRQALRVCSKLT 628
            |||||||.|||:|||||    |:||.|:.||||||||||||||||.|||||.:||||:
Mouse   586 CVSVDNLRGLEQPPSEG----LKRWWQESLGDSCFSLTDCQEVTAAYRQALGICSKLS 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUAK2	NP_112214.3	STKc_NUAK2	49..303	CDD:271063	242/261 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..493		110/140 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..562		27/30 (90%)
Nuak2	NP_001181954.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		6/19 (32%)
		Protein Kinases, catalytic domain	53..315	CDD:473864	242/261 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..485		86/112 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..575		35/45 (78%)