Protein Alignment NUAK2 and KP78b

DIOPT Version :10

• Sequence 1: NP_112214.3
• Gene: NUAK2 / 81788
• HGNCID: 29558
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_650065.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Alignment Length: 554
• Identity: 180/554 - (32%)
• Similarity: 246/554 - (44%)
• Gaps: 145/554 - (26%)

Human    53 YEFLETLGKGTYGKVKKA-RESSGRLVAIKSIRKDKIKD--EQDLMHIRREIEIMSSLNHPHIIA 114
            |:.::|||||.:.|||.| ...:||.||||.|.|..:..  .|.|.   ||:.||..||||:|:.
  Fly    63 YKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLY---REVNIMKKLNHPNIVR 124

Human   115 IHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLE 179
            :.:|.|:...:.:||||.|.|:|::|:.:..::.||:||..|||:|||:.|||...:||||||.|
  Fly   125 LLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAE 189

Human   180 NILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILV 244
            |:|||....:||||||.|..:.....|:||||||.||:||:..||.|:|||||||||||:||.||
  Fly   190 NLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLV 254

Human   245 HGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTRRATLEDVASHWWVNWGYA 308
            .|::||||.:.|.|..::..|.||.|...|..| .|||..|::|||:|.:|..|.:..|:|.||.
  Fly   255 SGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYE 319

Human   309 TRVG---EQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLER 370
            ...|   .||.|.:            :.|..|.|   ||.|
  Fly   320 QGNGLRPFQEKPMD------------LHDVNRLS---LLSN------------------------ 345

Human   371 QHSLKKSRKENDMAQSLHSDTADD------------------------------TAHRPGKSNLK 405
                 ...|..|:.|||.:...||                              || .||.|.:.
  Fly   346 -----MGHKPRDVEQSLKNQKFDDIYCTYMLLDVAKPRSTACSEKSGSSFRETPTA-MPGSSRIP 404

Human   406 LPKGILKKKVSASAEGVQEDPPE-----------------LSPIPASPGQAAPLLPKKGIL---- 449
            :|.......:|.....:.:..|.                 |:|:|.:|.      |||.|.
  Fly   405 VPIAAPNVTISQVTFALDKSTPNRPAATSIRPMAPRLANALTPLPLTPP------PKKYICCSAS 463

Human   450 KKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKE--QKPPQASGLLLHRKGILKLNGKFSQTA 512
            |....|.|      |||...:         |..||:  ..|......||..:..|.:|.|.:..:
  Fly   464 KAANPRRS------EPSSIPQ---------SAMPKKGVGSPVDVKTTLLSAQRKLAVNQKLTSAS 513

Human   513 LELAAPTT----------------FGSLDELAPP 530
            .::.:|.|                |..||..:.|
  Fly   514 HQIRSPITQSPSQASECTRTPPTHFEMLDSTSTP 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUAK2	NP_112214.3	STKc_NUAK2	49..303	CDD:271063	122/253 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..493		33/190 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..562		180/554 (32%)
KP78b	NP_650065.1	Protein Kinases, catalytic domain	63..314	CDD:473864	122/253 (48%)
		UBA_MARK_Par1	335..373	CDD:270522	13/69 (19%)