Protein Alignment NUAK2 and Sik3

DIOPT Version :10

• Sequence 1: NP_112214.3
• Gene: NUAK2 / 81788
• HGNCID: 29558
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Alignment Length: 574
• Identity: 175/574 - (30%)
• Similarity: 255/574 - (44%)
• Gaps: 131/574 - (22%)

Human    13 TPSAAELARPLAEGLIKSPK-PLMKKQAVKRHHHKHNLR-HRYEFLETLGKGTYGKVKKARESSG 75
            ||:|...|.|......::.| |...|.:|.:     .|| ..||..:|:|||.:..||.|.....
  Fly     4 TPTAGPAAAPPTSSTPQNYKVPSTSKISVDK-----LLRVGYYELEKTIGKGNFAVVKLATNIVT 63

Human    76 RL-VAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYD 139
            :. ||||.|.|..:.:|. |....|||.|:.||.||||..::||.|:.|.|.:|.|||..|:::|
  Fly    64 KTKVAIKIIDKTCLNEEY-LNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFD 127

Human   140 YISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGK 204
            ::....::.|.||...|.|:||||||||:..|||||||.||:|||.:.|||:||||.||.|.:|.
  Fly   128 HLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGA 192

Human   205 FLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYRE 269
            .|:|:||||.||:||:..|..|.||:.|.|||||:||.||.|.:||||.....|..::..|.:|.
  Fly   193 TLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRI 257

Human   270 PPKPSDAC-GLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMA 333
            |...|..| .|||.:|:|.|.||.|::.:..|.|                             ::
  Fly   258 PFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRW-----------------------------LS 293

Human   334 DWLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHR 398
            :|                                   |..:::..:..||:
  Fly   294 EW-----------------------------------QSEMQEQERFGDMS-------------- 309

Human   399 PGKSNLKLPKGILKKKVSASAEGVQED-PPELSPIPAS-----PGQAAPLLPKKGILKKPRQRES 457
            ||       .|.:.|..|.|:.|...| ||:|..:..:     ||..|.::.:    ....||..
  Fly   310 PG-------SGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQ----SVHEQRFD 363

Human   458 GYYSSPEPSESGELLDAGDVF-VSGDPKEQKPPQASGLLLHRKGILKLNGKFSQT--ALELAAPT 519
            ..|:               :: :..|..:|:..:...|..|.......:.|.|.|  .::.:.|.
  Fly   364 NIYA---------------IYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPV 413

Human   520 TFGSLDELAPPRPLARASRPSGAVS---EDSILSSESFDQLDLP--ERLPEPPL 568
            ...|||.|:   ||:.|:..|.|:.   .|..:..|.:...:|.  .|..:||:
  Fly   414 KQESLDRLS---PLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPV 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUAK2	NP_112214.3	STKc_NUAK2	49..303	CDD:271063	121/256 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..493		22/144 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..562		8/35 (23%)
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	120/281 (43%)
		UBA_SIK	335..380	CDD:270523	8/63 (13%)