Protein Alignment NUAK2 and Snrk

DIOPT Version :10

• Sequence 1: NP_112214.3
• Gene: NUAK2 / 81788
• HGNCID: 29558
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Alignment Length: 618
• Identity: 172/618 - (27%)
• Similarity: 272/618 - (44%)
• Gaps: 122/618 - (19%)

Human    53 YEFLETLGKGTYGKVKKARE-SSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIH 116
            |:..||||.|.:..||.||. .:|..||:|.:.|.|: |:....|:.:|:..|..:.||:::.::
  Fly    20 YDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKL-DDVSKAHLFQEVRCMKLVQHPNVVRLY 83

Human   117 EVFENSSKIVIVMEYASRGDLYDYISERQQ-LSEREARHFFRQIVSAVHYCHQNRVVHRDLKLEN 180
            ||.:..:|:.:|:|....|||||||.:... |||..||.:||||:.|:.||||..|||||||.||
  Fly    84 EVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHRDLKPEN 148

Human   181 IL-LDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILV 244
            :: .:..|.:|:.|||.||.:..|:.|:|||||..|::|||:.|..|..|.||.|||||:||:||
  Fly   149 VVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLV 213

Human   245 HGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTRRATLEDVASHWWVNWGYA 308
            .|..||:..:....:..|.:..|..|...|..| .||..:|:.:|.:|||:|::||..|:.
  Fly   214 CGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAWLK---- 274

Human   309 TRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPGGG----------- 362
             .:.|           .||..::...:|...||..|  |.:..:|..|....|.
  Fly   275 -PIDE-----------PDSTTSTSEHFLPLVSREQL--GEEDHAFIIQKMINGNIASKEEILQAL 325

Human   363 --------STTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVS--- 416
                    :.|..|..:..|::.|:|....|.|    .:|.:.:.|.::.||    :.:|.|
  Fly   326 DKNKYNHITATYFLLAELRLRRRREELAQKQRL----LNDASMKVGDASRKL----VPEKPSPTE 382

Human   417 ASAEGVQEDPPELSPIPASP-----GQAAPLLPKKGILKKPRQRES------------------- 457
            |...||   |..::..||:.     |:......|..|:::..:.||
  Fly   383 AQKGGV---PISINVTPAAQFANDGGKPDKRSRKCSIVREEDEEESATECTAVGNELKVTSSSRR 444

Human   458 -GYYSSP--------EPSESGELLDAGDVFVSGDPKEQKPP---QASGLLLHRKGILKLNGKFSQ 510
             .:..||        ..||.|.......:..||.|...:..   .....|.|:...::.:.|..:
  Fly   445 EAFSDSPFSRSIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVSVDATLAHKLKQMEKSAKIDE 509

Human   511 TALELAAPTTFGSLDELAPPRPLARASR----------------PSGAVSEDSILSSESFDQLDL 559
            ..|........|.|      :||..:|:                ||.:.||.|...:::.::..:
  Fly   510 DTLSGLKELEIGKL------KPLPSSSKNPVLTHRRTKLNKIRTPSCSSSEASDDDTKTRNKKKI 568

Human   560 PERLPEPPLRGCV--------SVDNLTGLEEPP 584
            .:.:.:.|:|..:        |.|:...|..||
  Fly   569 NKFVGDTPVRFRMHRRDSHDDSSDSQDQLYPPP 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUAK2	NP_112214.3	STKc_NUAK2	49..303	CDD:271063	107/253 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..493		34/195 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..562		8/46 (17%)
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	107/253 (42%)
		UBA_SNRK	296..338	CDD:270524	6/43 (14%)