Protein Alignment NUAK2 and Sik2

DIOPT Version :10

• Sequence 1: NP_112214.3
• Gene: NUAK2 / 81788
• HGNCID: 29558
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Alignment Length: 618
• Identity: 202/618 - (32%)
• Similarity: 278/618 - (44%)
• Gaps: 130/618 - (21%)

Human     5 VFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKK 69
            :||...|.||..:..:..:..|.| |.|.|:|.:...|...       |:...|:|||.:..||.
  Fly   101 LFASGGGSTPGPSPTSSAVGAGGI-SGKDLLKLKEPMRVGF-------YDIERTIGKGNFAVVKL 157

Human    70 ARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYAS 133
            ||.. :...||||.|.|.:: |:.:|..:.||:|||..|.|||||.:::|.|..:.|.||.||||
  Fly   158 ARHRITKNEVAIKIIDKSQL-DQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYAS 221

Human   134 RGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSN 198
            :|:::|||::..::||..||..|.||:|||.|||:..:||||||.||:|||.|.||||||||.||
  Fly   222 QGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSN 286

Human   199 LYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQIS 263
            .:..|:.|.|:||||.||:||:..||.|||||:|.|||||:||:||.|.:||||...:.|..::.
  Fly   287 HFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVL 351

Human   264 NGAYREPPKPSDAC-GLIRWLLMVNPTRRATLEDVASHWWV-------------NWG--YATRVG 312
            :|.:|.|...|..| .|||.:|::.||||.|::.:..|.|:             |.|  ..|.|.
  Fly   352 SGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQTSVE 416

Human   313 EQE------APHEGGHPGSDSARASM---------ADWL----RRSSRPLLENGAKVCSFFKQHA 358
            ..|      |.:.|  .|||..|||:         |.:|    |.|.:....||.
  Fly   417 PSEDILRIMAEYVG--IGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGL---------- 469

Human   359 PGGGSTTPGLERQHSLKKSRKENDMAQ----------SLHSDTADDTAHRPGKSNLKLPKGILKK 413
             |..:..........:..||.::...|          |..|..|.|..|:    .|...:.:|..
  Fly   470 -GASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHK----RLSRHQTVLMS 529

Human   414 KVSASAEGVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVF 478
            :.:|.|                  .|.|.:|..|         .|||:...|.
  Fly   530 ERNAHA------------------GATPTVPDPG---------PGYYAKYGPL------------ 555

Human   479 VSGDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPSGAV 543
                   |.|...:| ..|..|.|. .|.....|..:..|..:..|...|.|.| :..|..|..|
  Fly   556 -------QLPLPLTG-HSHLTGYLN-GGGVEVDASGIPLPMRYTPLPTAASPAP-SNCSSTSSRV 610

Human   544 SEDSILSSESFDQLDLPERLPEPPLRGCVSVDN 576
            ...|:.||.       |.  ...|:...:|:||
  Fly   611 GRHSLSSSS-------PR--SHRPVAISLSIDN 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUAK2	NP_112214.3	STKc_NUAK2	49..303	CDD:271063	125/255 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..493		23/147 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..562		8/30 (27%)
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	125/259 (48%)
		UBA_SIK	418..458	CDD:270523	11/41 (27%)