Protein Alignment NUAK2 and nuak2

DIOPT Version :10

• Sequence 1: NP_112214.3
• Gene: NUAK2 / 81788
• HGNCID: 29558
• Length: 628
• Species: Homo sapiens
• Sequence 2: NP_001121499.1
• Gene: nuak2 / 100158605
• XenbaseID: XB-GENE-5857794
• Length: 570
• Species: Xenopus tropicalis
• Alignment Length: 632
• Identity: 341/632 - (53%)
• Similarity: 409/632 - (64%)
• Gaps: 109/632 - (17%)

Human    35 MKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRR 99
            :::||||||.|||||:|||||||||||||||:||:||:|.||.|||||||||:||||||::||||
 Frog     8 LRRQAVKRHLHKHNLKHRYEFLETLGKGTYGRVKRARDSQGREVAIKSIRKDRIKDEQDMLHIRR 72

Human   100 EIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVH 164
            |.||||||.|||||:|:|||||||||||||||||:|||||||||||:||:.|||.|||||||||.
 Frog    73 ETEIMSSLCHPHIISIYEVFENSSKIVIVMEYASQGDLYDYISERQRLSDHEARRFFRQIVSAVQ 137

Human   165 YCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGP 229
            |||.|.:|||||||||||||.|.|:|||||||||:|:...:|||:||||||||||||||:||.||
 Frog   138 YCHANGIVHRDLKLENILLDENKNVKIADFGLSNIYNSESYLQTYCGSPLYASPEIVNGRPYVGP 202

Human   230 EVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATL 294
            |||||||||||||||||.|||||.|:|.||.|||:|||:||..||||||||||||||||.|||||
 Frog   203 EVDSWSLGVLLYILVHGCMPFDGQDYKKLVAQISSGAYKEPTHPSDACGLIRWLLMVNPERRATL 267

Human   295 EDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAP 359
            .||||||||||||...:.|.|  |   ...::|..|.:..|||||||||.:|.:|:..|.:||.|
 Frog   268 ADVASHWWVNWGYTQPLTEPE--H---FKDTESPLAIVGGWLRRSSRPLWDNNSKMRCFLRQHLP 327

Human   360 GGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAEGVQE 424
            ||..|     ||.|||:|:|||::.|.                                  .|.:
 Frog   328 GGTIT-----RQRSLKRSKKENNINQG----------------------------------AVTQ 353

Human   425 DPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKEQKPP 489
            .|.|..|       :.|..|||||||||:|||||||||||.:|  :|..|.::.:...|....||
 Frog   354 TPQEKIP-------SVPPAPKKGILKKPQQRESGYYSSPEHNE--DLTRAENIELPPSPLTPSPP 409

Human   490 Q---------------ASGLLLHRKGILKLNGKFSQTALELAAP-TTFGSLDELAP--------- 529
            :               .:|   .||||||.|||||.   ..||| .||.:||  .|
 Frog   410 EIPTCNTDSDRHDEPAPNG---GRKGILKRNGKFSS---PWAAPHLTFDALD--CPLNEEKMHGG 466

Human   530 --PRPLARASRPSGAVSEDSILSSESFDQLDLPERLPEPP------LRGCVSVDNLTGLEEPPSE 586
              ||     .|.|.::|::||||:|||:.||.|.:..|..      :|..:|.::|..|:|...:
 Frog   467 FLPR-----DRASSSISQESILSTESFELLDFPGKYRERTRGKTRLMRNSLSAEDLLQLDEGDKK 526

Human   587 G-----PGSCLRRWRQDPLGDSCFSL-TDCQEVTATYRQALRVCSKL 627
            .     ..:|.|.    .:.:||.|| ...:||...||.|:.:..:|
 Frog   527 DVTQLRDMACYRA----RVAESCLSLGAGEEEVMQVYRSAVLIGQEL 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NUAK2	NP_112214.3	STKc_NUAK2	49..303	CDD:271063	208/253 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..493		47/152 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..562		14/30 (47%)
nuak2	NP_001121499.1	Protein Kinases, catalytic domain	22..276	CDD:473864	208/253 (82%)