DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rps6ka1 and S6k

DIOPT Version :9

Sequence 1:	XP_006239145.1	Gene:	Rps6ka1 / 81771	RGDID:	620675	Length:	741	Species:	Rattus norvegicus
Sequence 2:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	395	Identity:	188/395 - (47%)
Similarity:	250/395 - (63%)	Gaps:	28/395 - (7%)

- Green bases have known domain annotations that are detailed below.

  Rat    40 QDSDEGILK--------EISITHH---------------VKAGSEKADPSHFELLKVLGQGSFGK 81
            :|||:..::        |:.|..|               |..|..|..|..|||.||||:|.:||
  Fly    26 RDSDDDRIELDDVDLEPELCINLHQDTEGQETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGK 90

  Rat    82 VFLVRKVTRPDNGHLYAMKVLKKATL--KVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLY 144
            ||.|||....|....:||||||||::  ..:|...|:.||:||..|.|||:|:|.|||||:||||
  Fly    91 VFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLY 155

  Rat   145 LILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKL 209
            |||::|.||:||..|.:|.:|.|:...|||:|:.|.|.|||.||||||||||||||||.:||:||
  Fly   156 LILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKL 220

  Rat   210 TDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRK 274
            |||||.||.|......::||||:||||||::.|.||..:.||||.|.|||:||||..||..::||
  Fly   221 TDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRK 285

  Rat   275 ETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRRE 339
            :|:..||||||.:|.:|:.||:.|:|.|.||....||||||:.|..::.|.|:..::|:.:..|.
  Fly   286 KTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARR 350

  Rat   340 IKPPFKPAVAQPDDTFYFDTEFTSRTPRDSP-GIPPSAGAHQLFRGFSFVATGLMEDDSKPRATQ 403
            ::||.||.:...||...|||.||.:.|.||| ....|..|:.:|:||::||..::||  ..||.:
  Fly   351 LEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAPSILED--MHRANR 413

  Rat   404 APLHS 408
            .|..|
  Fly   414 MPARS 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rps6ka1	XP_006239145.1	S_TKc	68..326	CDD:214567	147/259 (57%)
		STKc_RSK_N	72..388	CDD:270734	167/318 (53%)
		STKc_RSK1_C	422..712	CDD:271077
		Pkinase	424..681	CDD:278497
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	168/320 (53%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	168/320 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334260
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850