DRSC/TRiP Functional Genomics Resources

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Protein Alignment CAMK2D and RCK2

DIOPT Version :10

Sequence 1:NP_001308498.1 Gene:CAMK2D / 817 HGNCID:1462 Length:533 Species:Homo sapiens
Sequence 2:NP_013349.1 Gene:RCK2 / 850950 SGDID:S000004238 Length:610 Species:Saccharomyces cerevisiae


Alignment Length:399 Identity:116/399 - (29%)
Similarity:178/399 - (44%) Gaps:96/399 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    14 YQLFEELGKGAFSVVRRCMKIP---TGQEY--------AAKIINTKKLSA--RDHQKLEREARIC 65
            |:|..::|:||||.|.|.  ||   :..|:        |.|:|....||:  .||:|.::.....
Yeast   163 YKLINKIGEGAFSKVFRA--IPAKNSSNEFLTKNYKAVAIKVIKKADLSSINGDHRKKDKGKDST 225

Human    66 RLLKHPNI---VRLHDSIS--------------EEGFHYLVFDLVTGGELFEDIVAREYYSEADA 113
            :......:   |.||.::|              .:.::|::.:|:||||:|.:||...|:||..:
Yeast   226 KTSSRDQVLKEVALHKTVSAGCSQIVAFIDFQETDSYYYIIQELLTGGEIFGEIVRLTYFSEDLS 290

Human   114 SHCIQQILESVNHCHLNGIVHRDLKPENLLL--------------------ASKSKG-------- 150
            .|.|:|:..:|.|.|..|:||||:||||||.                    ....:|        
Yeast   291 RHVIKQLALAVKHMHSLGVVHRDIKPENLLFEPIEFTRSIKPKLRKSDDPQTKADEGIFTPGVGG 355

Human   151 ---AAVKLADFGLAIEVQGDQQAWFGFA-------GTPGYLSPEVLRKDPYGKPVDMWACGVILY 205
               ..||||||||:.::         |:       ||.||.:|||::.:.|...||||..|.:||
Yeast   356 GGIGIVKLADFGLSKQI---------FSKNTKTPCGTVGYTAPEVVKDEHYSMKVDMWGIGCVLY 411

Human   206 ILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
            .:|.|:|||:||....|.::|..|.|.|..|.||.::..||:.:.|:|.:.|:||....:.|..|
Yeast   412 TMLCGFPPFYDEKIDTLTEKISRGEYTFLKPWWDEISAGAKNAVAKLLELEPSKRYDIDQFLDDP 476

Human   271 WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRN----FSAAKSLLKKPDGVKINN 331
            |:             .|.|||.|.....:.|..........:.    |....|||..|..|.:.:
Yeast   477 WL-------------NTFDCLPKEGESSQKKAGTSERRHPHKKQFQLFQRDSSLLFSPAAVAMRD 528

Human   332 KANVVTSPK 340
            ..::..:.|
Yeast   529 AFDIGNAVK 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CAMK2DNP_001308498.1 STKc_CaMKII 12..303 CDD:270988 109/356 (31%)
CaMKII_AD 380..507 CDD:285524
RCK2NP_013349.1 STKc_RCK1-like 161..478 CDD:270998 102/325 (31%)
Blue background indicates that the domain is not in the aligned region.

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