Protein Alignment CAMK2D and MAPk-Ak2

DIOPT Version :10

• Sequence 1: NP_001308498.1
• Gene: CAMK2D / 817
• HGNCID: 1462
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_524769.1
• Gene: MAPk-Ak2 / 44573
• FlyBaseID: FBgn0013987
• Length: 359
• Species: Drosophila melanogaster
• Alignment Length: 369
• Identity: 116/369 - (31%)
• Similarity: 175/369 - (47%)
• Gaps: 68/369 - (18%)

Human     8 TRFTDEYQLFEE-LGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARI------C 65
            |..||:|..... ||.|....|.:|....|.|.||.|::       .|.::..||..:      |
  Fly    13 TPLTDDYVTSNTVLGYGINGKVVQCTHRRTQQNYALKVL-------LDSERARREVDLHWRVSGC 70

Human    66 RLLKHPNIVRLHD-SISEEGFHYLVFDLVTGGELFEDI--VAREYYSEADASHCIQQILESVNHC 127
            |.:  .||:.::: :..:.....:|.:.:.|||||:.|  .|...::|.:|:..:.:|..:|::.
  Fly    71 RYI--VNIIDVYENTFKDRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYL 133

Human   128 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAG--------TPGYLSPE 184
            |...|.||||||||||..:....|.:||.|||.|.|.         |..        ||.|::||
  Fly   134 HSRDIAHRDLKPENLLYTTTQPNATLKLTDFGFAKET---------FTSYTLQTPCYTPYYVAPE 189

Human   185 VLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRL------YQQIKAGAYDFPSPEWDTVTP 243
            ||..:.|.|..|:|:.||::||::.|:|||:  ..|.|      ..:|:.|.||||.|||..|:.
  Fly   190 VLGPEKYDKSCDIWSLGVVMYIIMCGFPPFY--SNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQ 252

Human   244 EAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGA----- 303
            .|||||..||.::|:||:...:.:.:.||.|.:.|      .:|..|     ..|.||.|
  Fly   253 AAKDLIKGMLNVDPSKRLRIQDVISNKWIAQYNAV------PQTPLC-----TGRMLKEAEETWP 306

Human   304 ----ILTTMLATRNFSAAKSLLKKPDGVKINNKANVVTSPKENI 343
                .:|..|||......:..:|..|  |.||.  ::|..::.|
  Fly   307 EVQEEMTRSLATMRVDYDQMQIKALD--KSNNP--LLTKRRKKI 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2D	NP_001308498.1	STKc_CaMKII	12..303	CDD:270988	102/314 (32%)
		CaMKII_AD	380..507	CDD:285524
MAPk-Ak2	NP_524769.1	STKc_MAPKAPK	18..280	CDD:270991	92/281 (33%)