Protein Alignment CAMK2D and CaMKII

DIOPT Version :10

• Sequence 1: NP_001308498.1
• Gene: CAMK2D / 817
• HGNCID: 1462
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_001162833.1
• Gene: CaMKII / 43828
• FlyBaseID: FBgn0264607
• Length: 531
• Species: Drosophila melanogaster
• Alignment Length: 551
• Identity: 385/551 - (69%)
• Similarity: 433/551 - (78%)
• Gaps: 74/551 - (13%)

Human     1 MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
            ||:...||||:|.|.:.|||||||||:|:||::..||.|:||||||||||:|||.||||||||||
  Fly     1 MAAPAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARIC 65

Human    66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 130
            |.|.|||||||||||.||.:|||||||||||||||||||||:|||||||||||||||||||||.|
  Fly    66 RKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQN 130

Human   131 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPV 195
            |:|||||||||||||||:|||||||||||||||||||.||||||||||||||||||:|:||||.|
  Fly   131 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSV 195

Human   196 DMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKR 260
            |:||||||||||||||||||||||||||.||||||||:|||||||||||||:|||:|||:||.||
  Fly   196 DIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKR 260

Human   261 ITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPD 325
            |||:|||||||||||..|||::|||||||||||||||||||||||||||||||||:...:.||.:
  Fly   261 ITAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGE 325

Human   326 GVKINNKANVVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVK------------ 378
            |.::                                ||||:||:||:||:|:|
  Fly   326 GSQV--------------------------------KESTDSSSTTLEDDDIKEDKKGTVDRSTT 358

Human   379 ------------------------------ARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTA 413
                                          ||:|||||:|||||||||:|||:.|||||||.|||
  Fly   359 VVSKEPEDIRILCPAKTYQQNIGNSQCSSAARRQEIIKITEQLIEAINSGDFDGYTKICDPHLTA 423

Human   414 FEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMP 478
            ||||||||||||:|||:|||||.|.|:.|.|:|.||||||||:|::||||||:|||||:|..|..
  Fly   424 FEPEALGNLVEGIDFHKFYFENVLGKNCKAINTTILNPHVHLLGEEAACIAYVRLTQYIDKQGHA 488

Human   479 KTMQSEETRVWHRRDGKWQNVHFHRSGSPTV 509
            .|.|||||||||:||.||||||||||.|..:
  Fly   489 HTHQSEETRVWHKRDNKWQNVHFHRSASAKI 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2D	NP_001308498.1	STKc_CaMKII	12..303	CDD:270988	251/290 (87%)
		CaMKII_AD	380..507	CDD:285524	97/126 (77%)
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	251/290 (87%)
		CaMKII_AD	390..517	CDD:285524	97/126 (77%)