Protein Alignment CAMK2D and CASK

DIOPT Version :10

• Sequence 1: NP_001308498.1
• Gene: CAMK2D / 817
• HGNCID: 1462
• Length: 533
• Species: Homo sapiens
• Sequence 2: NP_001262811.1
• Gene: CASK / 42567
• FlyBaseID: FBgn0013759
• Length: 929
• Species: Drosophila melanogaster
• Alignment Length: 614
• Identity: 192/614 - (31%)
• Similarity: 277/614 - (45%)
• Gaps: 146/614 - (23%)

Human    10 FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKK------LSARDHQKLEREARICRLL 68
            |.|.|:|.|.:|||.||:||||:...:.|::|.||::..|      ||..|   |:|||.||.:|
  Fly     8 FDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTAD---LKREATICHML 69

Human    69 KHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVARE----YYSEADASHCIQQILESVNHCHL 129
            |||:||.|.::.|.||..|:||:.:.|.:|..::|.|.    .||||.|.|.::||||::.:||.
  Fly    70 KHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHE 134

Human   130 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA--WFGFAGTPGYLSPEVLRKDPYG 192
            |.|:|||::|...|||:....|.|||..||.||::.|.::.  ..|..|.|.|::|||:.:..||
  Fly   135 NDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYG 199

Human   193 KPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP 257
            |..|:|..||:|::||.|..||..... ||.|.:..|...|.:|||.:::..||||:.|||..||
  Fly   200 KGCDVWGAGVMLHVLLSGRLPFLGSGV-RLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANP 263

Human   258 AKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAI--------LTTMLAT--- 311
            ..|::.:|.|.||||..|..: ...|..:||:.||::|||||||||:        :..:.||
  Fly   264 HHRLSITEVLDHPWIRDRDKL-QRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDAD 327

Human   312 --------------RNFSAAKSLLKKPDGVKI----------------NNK------------AN 334
                          ....|.:.:|...|.:..                :|:            |.
  Fly   328 MPITGATDEWADEEAGIEAVQRILDCLDDIYSLQDAHVDADVLRDMLRDNRLHQFLQLFDRIAAT 392

Human   335 VVTSPKENIPTPALEP-----------QTTVIHNPDGNKESTES---------SNTTIEDEDVKA 379
            ||||   |...||.|.           .:|...|..|.|.:.|.         ....:...||.|
  Fly   393 VVTS---NGRAPAAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVA 454

Human   380 RK---QEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFH---RFYFENALS 438
            |.   :|.::||...:....|||                  .|.| |||.:..   |........
  Fly   455 RDVYGEEALRVTPPPMVPYLNGD------------------ELDN-VEGGELQHVTRVRLVQFQK 500

Human   439 KSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGM---PKTMQ-SEETR------VWHRRD 493
            .:::|:...:      .:.:|..||    :.:.|.| ||   ..|:. .:|.|      |.|:..
  Fly   501 NTDEPMGITL------KMTEDGRCI----VARIMHG-GMIHRQATLHVGDEIREINGQPVQHQSV 554

Human   494 GKWQNVHFHRSGSPTVPI-------KPPC 515
            |:.|.:.....||.|..|       .|||
  Fly   555 GQLQRMLREARGSVTFKIVPSYRSAPPPC 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAMK2D	NP_001308498.1	STKc_CaMKII	12..303	CDD:270988	131/302 (43%)
		CaMKII_AD	380..507	CDD:285524	29/142 (20%)
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	132/304 (43%)
		L27	347..396	CDD:460717	6/48 (13%)
		L27	406..462	CDD:460717	9/55 (16%)
		PDZ_CASK-like	494..574	CDD:467267	19/90 (21%)
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:395500